规格 | 100 mg |
数量 | 货期:14天 |
保存条件 | Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month. |
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CAS No. : 68890-65-3
MCE 国际站:Intralipid
产品活性:Intralipid 是一种安全的脂肪乳剂,可以用作营养补充剂。Intralipid 可以有效地抑制线粒体通透性转换孔的开放,有效地保护心脏免受缺血再灌注损伤 ,并具有一定调节先天免疫反应的潜力。
研究领域:Others
作用靶点:Others
In Vitro: Intralipid (0-0.2 mg/mL) specifically protects immune cells from paclitaxel, but has no effect on tumor cells.
Intralipid (0-0.2 mg/mL, 3 days) promotes polarisation of M0, M1 and M2 macrophages to an M1-like phenotype.
In Vivo: Intralipid (2 g/kg) does not affect phagocytosis and may promote macrophage polarization to the M1 phenotype, as observed in breast cancer tumor sections from Balb/c mice.
Intralipid pretreatment promotes the accumulation of paclitaxel in tumour tissue and induces higher levels of apoptosis in tumour cells. Increased distribution of paclitaxel in mouse RES organs and enhanced inhibition of tumour growth.
Intralipid (5 mL/kg) is more effective than cyclosporin-A in protecting the heart from I/R injury in SD rats, reducing the size of myocardial infarction by approximately 40%.
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