创新科研试剂：L-NAME hydrochloride，助力生命科学探索,化工产品

创新科研试剂：L-NAME hydrochloride，助力生命科学探索

2025年02月07日 16:13 化工产品

关键词：L-NAME hydrochloride；51298-62-5

中文别名：N'-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯;N(ω)-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲酯盐酸盐;NG-硝基-L-精氨酸甲基酯盐酸盐;NG-硝基-L-精氨酸甲酯盐酸盐;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride N(ω)-硝基-L-精氨酸甲酯盐酸盐;Nω-硝基-L-精氨酸甲酯盐酸盐;N-硝基-L-精氨酸甲基酯盐酸盐;N''-硝基-L-精氨酸甲酯盐酸盐;一氧化氮合酶抑制剂;N’-硝基-L-精氨酸甲酯盐酸盐;精氨酸硝基盐酸盐
英文名称：Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride
英文别名：(S)-Methyl 2-amino-5-(3-nitroguanidino)pentanoate hydrochloride;H-Arg(NOZ)-OMe.HCl;L-NAME hydrochloride;N'-Nitro-L-arginine methyl ester hydrochloride;Nomega-Nitro-L-arginine Methyl Ester Hydrochloride;L-NAME;(S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride;H-Arg(NO?)-OMe·HCl;H-Arg(NO₂)-OMe · HCl;H-Arg(NO2)-OMe.HCl;H-Arg(NO2)-OMe·HCl;H-Arg(NO2)-OMe·HClN-ω-Nitro-L-arginine methyl ester hydrochloride;H-Arg(NO2)-OMe•HCl;L-NAME (hydrochloride);L-NAME,BR;methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate,hydrochloride;NG-Nitroarginine methyl ester hydrochloride;Nitroarginine Methyl;Nitroarginine Methyl Ester Hydrochloride;N'-Nitro-L-arginine-methyl ester hydrochloride;N-ω-Nitro-L-arginine methyl ester hydrochloride;Nω-Nitro-L-arginine methyl ester hydrochloride;NG-Nitro-L-arginine-methyl ester hydrochloride;LNAME hydrochloride;L-NAME HCl;NG-Nitro-L-arginine methyl ester hydrochloride;L-NAME, HCl;L-NAME HCl;NG-NO2-L-Arg-OMe;H-Arg(NO)-OMe HCl;Nomega-NO2-L-Arg-OMe;Methyl N5-(imino(nitroamino)methyl)-L-ornithine monohydrochloride;H-Arg(NO2)-OMeHCl;methyl (2S)-2-amino-5-(3-
Cas No. ：51298-62-5
分子式：C7H16ClN5O4
分子量：269.69
包装储存：

-20°C, sealed storage, away from moisture

生物活性：
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
性状：Solid

化学性质
靶点：eNOS（内皮型一氧化氮合酶）等
功能：L-NAME hydrochloride是一种无选择性的一氧化氮合成酶（NOS）抑制剂，对神经元型一氧化氮合酶（nNOS）、内皮型一氧化氮合酶（eNOS）以及在损伤后诱导表达的诱导型一氧化氮合酶（iNOS）均有抑制效果。其作用于nNOS、eNOS和iNOS的Ki值分别为15 nM、39 nM、4.4 μM。
其他化学性质：L-NAME抑制内皮细胞中cGMP形成，IC50为3.1 μM（细胞中含有30 μM精氨酸）。另外，在大鼠主动脉环中，L-NAME可以逆转乙酰胆碱的血管舒张作用（EC50=0.54 μM）。

体外研究(In Vitro)
L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with N-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)
L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and IFNγ production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件
Room temperature or refrigerated transportation.
储存方式
-20°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
ClinicalTrial

参考文献
[1]. Pfeiffer S, et al. Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement forbioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol. 1996 Jul;118(6):1433-40. [Information]
[2]. Kopincová J, et al. L-NAME in the cardiovascular system - nitric oxide synthase activator? Pharmacol Rep. 2012;64(3):511-20. [Information]
[3]. Lo HC, et al. The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis. PLoSOne. 2016 Mar 23;11(3):e0151973. [Information]
[4]. Luo H, et al. Effect of nitric oxide synthase inhibitor L-NAME on fear extinction in rats: a task-dependent effect. Neurosci Lett. 2014 Jun 20;572:13-8. [Information]
[5]. Ocsan RJ, et al. Chronic NG-nitro-l-arginine methyl ester (L-NAME) administration in C57BL/6J mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol. 2013 Dec;64(6):727-36. [Information]

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