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★【medlife】(±)-Acetylcarnitine chloride

2024年06月07日 17:01   化工产品  

上海陌孚医药科技有限公司 发布 访问商铺

关键词:(±)-Acetylcarnitine chloride;2504-11-2

弱胆碱能激动剂;脂质代谢中的中间体,(±)-Acetylcarnitine chloride是一种胆碱能激动剂 。

中文名称
(±)-Acetylcarnitine chloride
英文名称
(±)-Acetylcarnitine chloride
英文别名
1-Propanaminium,2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, chloride (1:1);(±)-Acetylcarnitine chloride;ACETYL-DL-CARNITINE HCL;(+/-)-ACETYLCARNITINE CHLORIDE;(+-)-(2-acetoxy-3-carboxy-propyl)-trimethyl-ammonium, chloride;(+-)-Acetylcarnitine chloride;(1)-(2-Acetoxy-3-carboxypropyl)trimethylammonium chloride;Acetyl dl-carnitine chloride;Acetylcarnitin-chl;D,L-Acetylcarnitin-chlorid [German];EINECS 219-709-3;O-Acetylcarnitinhydrochlorid;R-(-)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride;rac. Acetyl-carnithin;rac. Acetylcarnitinchlorid;(±)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride;Acetyl-DL-carnitine hydrochloride
Cas No.
2504-11-2
分子式
C9H18NO4+.Cl-
分子量
239.70
包装储存
Sealed and stored at -20℃, moisture-proof
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性
(±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist with cholinergic properties. (±)-Acetylcarnitine chloride is an important intermediate in lipid metabolism.
性状
Solid
体外研究(In Vitro)
Large increases of Acetylcarnitine concentration during the flight of the blowfly and the presence of an active Acetylcarnitine transferase indicate that Acetylcarnitine is important in carbohydrate metabolism. Acetylcarnitine has been synthesized by the choline acetylase system isolated from brain tissue and is destroyed by cholinesterase.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
In rats, the infusion of 2 mg (±)-Acetylcarnitine chloride decreases blood flow through the hind limb vasculature 50%. (±)-Acetylcarnitine chloride also potentiates the inhibitory effect of adrenaline on the isolated rabbit duodenum.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.
储存方式
Sealed and stored at -20℃, moisture-proof
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. R A Chalmers, et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. Pediatr Res. 1984 Dec;18(12):1325-8.  [Information]
[2]. R L Sass, et al. Acetylcarnitine: on the relationship between structure and function. Biochem Biophys Res Commun. 1973 Dec 10;55(3):736-42.  [Information]
[3]. R T Louis-Ferdinand, et al. Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides. J Pharm Pharmacol. 1970 Sep;22(9):704-5.  [Information]


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Medlife小分子化合物大量库存,提供超过2万种的抑制剂、激动剂、拮抗剂等产品,是药物及疾病研究的重要原料供应商。



化工词典
  • 中文名称:
  • 英文名称: (±)-Acetylcarnitine chloride
  • CAS NO.: 2504-11-2
  • 分子式: C9H18NO4+.Cl-
  • 分子量:239.69652
结构式图片|2504-11-2结构式图片
查看更多物化属性、结构等信息,点击: 2504-11-2
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