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异甘草素 | Isoliquiritigenin - MedChemExpress

2022年12月08日 13:20   化工产品  

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关键词:异甘草素

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异甘草素

CAS No. : 961-29-5

MCE 国际站:Isoliquiritigenin

产品活性:Isoliquiritigenin 是从甘草中分到的黄酮类化合物,具有抗肿瘤的活性,能够抑制 aldose reductase 的活性,IC50 值为 320 nM。Isoliquiritigenin 是一种流感病毒 (influenza virus) 复制的有效抑制剂,EC50 为 24.7 μM。

研究领域:Metabolic Enzyme/Protease  |  Anti-infection  |  Autophagy  |  Apoptosis

作用靶点:Aldose Reductase  |  Influenza Virus  |  Autophagy  |  Apoptosis

结构分类:酚类  |  多酚类  |  黄酮类  |  查耳酮

来源:植物  |  豆科  |  甘草

In Vitro: Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. Isoliquiritigenin (100 μM) markedly inhibits the hypoxia-induced prolonged TPS and TR90 of cardiomyocytes. Isoliquiritigenin significantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenin treatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes. Isoliquiritigenin treatment significantly decreases the intracellular ROS levels of isolated cardiomyocytes during hypoxia/reoxygenation. Isoliquiritigenin not only downregulates IL-6 expression but also significantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks.

In Vivo: Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum induced by various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC50 values of 4.96±1.97 mM, 4.03±1.34 mM and 3.70±0.58 mM, respectively. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin.

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