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2-脱氧-D-葡萄糖 | 2-Deoxy-D-glucose - MedChemExpress

2022年12月08日 13:18   化工产品  

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关键词:2-脱氧-D-葡萄糖

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2-脱氧-D-葡萄糖

CAS No. : 154-17-6

MCE 国际站:2-Deoxy-D-glucose

产品活性:2-Deoxy-D-glucose 是一种葡萄糖类似物,为葡萄糖代谢抑制剂,通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。

研究领域:Metabolic Enzyme/Protease  |  Anti-infection  |  Apoptosis

作用靶点:Hexokinase  |  HSV  |  Apoptosis

结构分类:糖类  |  单糖

In Vitro: 2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.

In Vivo: 2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.

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