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他克莫司相关化合物A | Ascomycin - MedChemExpress

2022年12月06日 13:36   化工产品  

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关键词:他克莫司相关化合物A

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他克莫司相关化合物A

CAS No. : 104987-12-4

MCE 国际站:Ascomycin

产品活性:Ascomycin (Immunomycin; FR-900520; FK520) 是 Tacrolimus (FK506) 的乙基类似物,具有很强的免疫抑制特性。Ascomycin 也是一种大环聚酮类抗生素,具有抗疟疾、抗真菌和抗痉挛等多种生物活性。Ascomycin 可防止移植排斥,并具有用于各种皮肤病研究的潜力。

研究领域:Apoptosis  |  Immunology/Inflammation  |  Autophagy  |  Anti-infection

作用靶点:FKBP  |  Parasite  |  Fungal  |  Antibiotic

结构分类:抗生素  |  大环内脂类

In Vitro: Ascomycin (FR-900520) suppresses immune response in vitro with an IC50 value of 0.55 nM for mouse mixed lymphocyte reaction.
Ascomycin is a powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN and to interfere with the dephosphorylation of various substrates.

In Vivo: Ascomycin (FR-900520; i.m.; 0.32-32 mg/kg; 5 days a week; for 2 weeks) clearly prolongs skin allograft survival in rats.

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