MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

他克莫司相关化合物A

CAS No. : 104987-12-4

MCE 国际站：Ascomycin

产品活性：Ascomycin (Immunomycin; FR-900520; FK520) 是 Tacrolimus (FK506) 的乙基类似物，具有很强的免疫抑制特性。Ascomycin 也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。Ascomycin 可防止移植排斥，并具有用于各种皮肤病研究的潜力。

研究领域：Apoptosis  |  Immunology/Inflammation  |  Autophagy  |  Anti-infection

作用靶点：FKBP  |  Parasite  |  Fungal  |  Antibiotic

结构分类：抗生素  |  大环内脂类

In Vitro: Ascomycin (FR-900520) suppresses immune response in vitro with an IC₅₀ value of 0.55 nM for mouse mixed lymphocyte reaction.
Ascomycin is a powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN and to interfere with the dephosphorylation of various substrates.

In Vivo: Ascomycin (FR-900520; i.m.; 0.32-32 mg/kg; 5 days a week; for 2 weeks) clearly prolongs skin allograft survival in rats.

相关产品：Covalent Screening Library Plus  |  Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Natural Product Library  |  Autophagy Compound Library  |  Peptidomimetic Library  |  Covalent Screening Library  |  Macrocyclic Compound Library  |  Antifungal Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Antiparasitic Compound library  |  Microbial Metabolite Library  |  Antifungal agent 26  |  Quinidine-d3  |  Acridine Orange base  |  N-Desethyl amodiaquine-d5  |  Doxorubicin-13C,3d TFA  |  PC945  |  Palitantin  |  Proguanil-d6  |  Proanthocyanidins  |  Azlocillin sodium salt  |  Chitin synthase inhibitor 11  |  Toyocamycin  |  SPR206 acetate  |  Doxycycline calcium  |  Staurosporine  |  Dihydrostreptomycin sulfate  |  Phenazine-1-carboxylic acid  |  Ciclopirox olamine  |  WX-081  |  SQ109  |  Neomycin sulfate  |  Concanavalin A  |  Aminothiazole  |  Antimycin A3  |  13,21-Dihydroeurycomanone  |  Framycetin  |  Colistin sulfate  |  L-Lactic acid-2-13C1  |  Griseofulvin-d3

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides