(-)-表没食子儿茶素没食子酸酯 | (-)-Epigallocatechin Gallate - MedChemExpress
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(-)-表没食子儿茶素没食子酸酯
CAS No. : 989-51-5
MCE 国际站：(-)-Epigallocatechin Gallate
产品活性：(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚，可抑制细胞增殖并诱导细胞凋亡。 (-)-Epigallocatechin Gallate sulfate 可抑制谷氨酸脱氢酶 1/2 (GDH1/2, GLUD1/2) 的活性。(-)-Epigallocatechin Gallate sulfate 对结直肠癌、髓性白血病、甲状腺癌等多种癌症具有有效的抗癌、抗氧化和抗炎特性。
研究领域：Metabolic Enzyme/Protease
In Vitro: (-)-Epigallocatechin Gallate (EGCG, 10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner.
(-)-Epigallocatechin Gallate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression.
(-)-Epigallocatechin Gallate (10-60 μM, 12 h) reduces cell motility and migration.
(-)-Epigallocatechin Gallate (0-20 μM, 0-20 min approximately) inhibits GLUD1/2 and IDH1 activity in a concentration and time-dependent way (biochemical assays).
(-)-Epigallocatechin Gallate (0-35 μg/mL, 24-72 h) inhibits the proliferation of colorectal cancer cells (LoVo, SW480, HT-29, HCT-8 cells), increases cell apoptosis and blocks cells at the G0/G1 phase.
(-)-Epigallocatechin Gallate (30 μM, 3-24 h) suppresses the expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production in LPS-induced osteoblasts.
In Vivo: (-)-Epigallocatechin Gallate (Intragastrical administration, 5-20 mg/kg, once daily for 14 days, orthotopic transplant model) decreases tumors growth.
(-)-Epigallocatechin Gallate (Injected into the mouse lower gingiva, a single dose of 0.5 mg/mouse, experimental periodontitis model) decreases inhibits the LPS-induced loss of bone mineral density (BMD).
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