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紫杉醇 | Paclitaxel - MedChemExpress

2022年11月24日 08:57   化工产品  

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紫杉醇

CAS No. : 33069-62-4

MCE 国际站:Paclitaxel

产品活性:Paclitaxel 是一种天然抗肿瘤药,可稳定微管蛋白 (tubulin) 的聚合。Paclitaxel 可导致有丝分裂停滞和诱导细胞凋亡 (apoptosis),最终导致细胞死亡。Paclitaxel 还可诱导细胞自噬 (autophagy)。

研究领域:Cell Cycle/DNA Damage  |  Cytoskeleton  |  Antibody-drug Conjugate/ADC Related  |  Apoptosis  |  Autophagy

作用靶点:Microtubule/Tubulin  |  ADC Cytotoxin  |  Apoptosis  |  Autophagy

来源:植物  |  红豆杉科  |  红豆杉  |  植物  |  八角科  |  红豆杉

In Vitro: Paclitaxel (20 nM; 48 hours) induces programmed cell death and exists a block at the G2/M phase of the cell cycle.
Paclitaxel (20 nM; 48 hours) induces a consistent increase in the level of p53.

In Vivo: Paclitaxel (1-20 mg/kg; i.p.; 1 time/2 days for five cycles) obviously induces liver metastases at the low-Paclitaxel group with little influence on primary tumor growth.

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