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Introduction
Bortezomib (PS-341) 是一种可逆性和选择性的蛋白酶体 (proteasome) 抑制剂,通过靶向苏氨酸残基有效抑制 20S 蛋白酶体 (Ki=0.6 nM)。Bortezomib 破坏细胞周期、诱导细胞凋亡以及抑制核因子 NF-κB。Bortezomib 是第一种蛋白酶体抑制剂,具有抗癌活性。
Names and Identifiers
  • Bortezomib
  • MG-341
  • PS-341
  • [(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid
  • dpba
  • VELCADE
  • VELCADE(BORTEZOMIB)
  • Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-
  • Bortezomib for research
  • Bortezomib (PS-341)
  • ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
  • bortezomib(Velcade®, Bortecad®, PS-341,MG-341)
  • Bortizomib
  • &nbsp
  • Bortezmib
  • Bortezomib Base
  • MG-341 PS-341
  • PS341
  • Radiciol
  • MLM341
  • BortezoMib R
  • BortezoMib-D8
  • MG-341 PS-341
  • Ps 341
  • N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
  • Bortezomib (Velcade)
  • [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
  • [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
  • Peptide boronate
  • 69G8BD63PP
  • Boronic acid, B-[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl
  • MDL:MFCD27978443
  • InChIKey:GXJABQQUPOEUTA-RDJZCZTQSA-N
  • Inchi:1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
  • SMILES:CC(C[C@H](NC([C@@H](NC(C1=CN=CC=N1)=O)CC1=CC=CC=C1)=O)B(O)O)C
Chemical and Physical Properties

Computed Properties

  • Exact Mass: 384.2g/mol
  • Surface Charge: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 6
  • Rotatable Bond Count: 9
  • Exact Mass: 384.196886g/mol
  • Monoisotopic Mass: 384.196886g/mol
  • Topological Polar Surface Area: 124Ų
  • Heavy Atom Count: 28
  • Complexity: 500
  • Isotope Atom Count: 0
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count: 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Covalently-Bonded Unit Count: 1

Experimental Properties

  • LogP: 1.56230
  • PSA: 124.44000
  • 折射率: 1.56
  • 沸点: 684.30° C
  • 熔点: 139-143°C
  • 稳定性: Hygroscopic and Moisture Sensitive
  • 密度: 1.214
Security Information
  • RTECS号:ED7771666
  • 安全说明:S26-S36/37/39
  • 风险术语:R34
  • 危險品標誌: C C
  • 危险品运输编号:3261
  • 危害声明:H300; H310; H330; H372
  • 警示性声明:P260; P284; P301+P310; P304+P340; P320; P330; P361; P302+P350; P405; P501
  • 储存条件:4°C, protect from light
  • PackingGroup:II
  • 危险类别码:23/24/25-48/23/24/25
  • 信号词:Warning
  • HazardClass:6.1
Customs Data
  • 海关编码:2934999090
  • 海关数据:

    中国海关编码:

    2934999090

    概述:

    2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

    申报要素:

    品名, 成分含量, 用途

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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