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  2. 19542-67-7
BAY 11-7082 | 19542-67-7

Product name:BAY 11-7082

CAS No:19542-67-7
MF:C10H9NO2S
MW:207.248961210251
MDL:MFCD00712162
CID:825140
Introduction
Bay 11-7082 (Bay 11-7821) is an I κ B α Phosphorylation and NF- κ B inhibitors, which selectively and irreversibly inhibit TNF- α Induced I κ B- α Phosphorylation, and reduced NF- κ B and the expression of adhesion molecules Bay 11-7082 inhibited ubiquitin specific proteases USP7 and usp21 (IC50 = 0.19, 0.96 μ M) Bay 11-7082 inhibited gasdermin D (gsdmd) pore formation in liposomes as well as inflammasome mediated apoptosis and IL-1 in human and mouse cells β Secretion of
Names and Identifiers
  • (E)-3-Tosylacrylonitrile
  • BAY 11-7082
  • (E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
  • (E)-3-(P-TOLUENESULFONYL)ACRYLONITRILE
  • Bay 11-7082 (Bay 11-7821)
  • BAY 11-7821
  • BAY-11-7082
  • (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
  • BAY 117821
  • BAY11-7082,BAY 117821
  • (E)-3-(p-tolylsulfonyl)prop-2-enenitrile
  • (2E)-3-[(4-METHYLPHENYL)SULFONYL]-2-PROPENENITRILE
  • BAY117082
  • 4Y5G2A4F6O
  • 3-(4-methylphenylsulfonyl)-2-propenenitrile
  • 3-[(4-methylphenyl)sulfonyl]prop-2-enenitrile
  • (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
  • MSSA ATCC 25923
  • MRSA USA300 SF8300
  • P. aeruginosa
  • MDL:MFCD00712162
  • InChIKey:DOEWDSDBFRHVAP-KRXBUXKQSA-N
  • Inchi:1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
  • SMILES:S(/C=C/C#N)(C1C=CC(C)=CC=1)(=O)=O
Chemical and Physical Properties

Computed Properties

  • Exact Mass: 207.03500
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Rotatable Bond Count: 2
  • Heavy Atom Count: 14
  • Complexity: 347
  • Topological Polar Surface Area: 66.3

Experimental Properties

  • LogP: 2.88678
  • PSA: 66.31000
  • Boiling Point: 397.6°C at 760 mmHg
  • Melting Point: 132.0 to 136.0 deg-C
  • Solubility: Very slightly soluble (0.33 g/l) (25 º C),
  • Density: 1.237±0.06 g/cm3 (20 ºC 760 Torr),
Security Information
  • Symbol: GHS07
  • RTECS:UD1430000
  • WGK Germany:3
  • Hazardous Material transportation number:NONH for all modes of transport
  • Hazard Statement:H302-H315-H319
  • Warning Statement:P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
  • Prompt:warning
  • Storage Condition:0-10°C
  • Signal Word:Warning
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