1. chem960
  2. 65271-80-9
Mitoxantrone | 65271-80-9

Product name:Mitoxantrone

CAS No:65271-80-9
MF:C22H30Cl2N4O6
MW:517.4028
CID:58304
PubChem ID:4212
Introduction
Mitoxantrone has the chemical formula of 1,4-dihydroxy-5,8-bis [[2 - [(2-hydroxyethyl) amino] ethyl] amino] - 9,10-anthraquinone, blue black crystal, melting point 203-205 ℃. It is slightly soluble in water, slightly soluble in ethanol, insoluble in chloroform and acetone. It is odorless and moisture-absorbing.
Names and Identifiers
  • mitoxantrone hydrochloride
  • Mitoxantrone HCL
  • mitoxanthrone
  • DHAQ
  • Mitoxantrone
  • 1,4,5,8-TETRAHYDROXY-9,10-ANTHRACENEDIONE
  • mitozantrone
  • [3H]-Mitoxantrone
  • 1,4-bis-[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxy-9,10-anthracenedione
  • 1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone
  • 1,4-dehydroxy-5,8-bis[[[2-(2-hydroxyethyl)amino]ethyl]amino]-9,19-antracenedion
  • 1,4-dihydroxy-5,8-bis[[2-(2-hydroxy-ethylamino)ethyl]amino]anthraquinone
  • dihydroxyanthraquinone
  • MITOXANTRONUM
  • MITOXANTRONUM AND THE INTERMEDIATES
  • PharmasubstanceEP4
  • 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione
  • 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone
  • 1,4-Dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione
  • Mitoxantrone dihydrochloride
  • Novantron
  • Novantrone
  • Immunex
  • Mitoxantrone 2HCl
  • Bisantrone
  • DHAD
  • Mitoxantrone (dihydrochloride)
  • MITOXANTHRONE HYDROCHLORIDE
  • Mitozantrone hydrochloride
  • U6USW86RD0
  • 1,4-dihydroxy-5,8-bis-[2-(2-hydroxyethylamino)ethylamino]anthraquinone 2hcl
  • CL 232315
  • novatrone
  • 1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)e
  • InChIKey:ZAHQPTJLOCWVPG-UHFFFAOYSA-N
  • Inchi:1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
  • SMILES:Cl[H].Cl[H].O=C1C2=C(C([H])=C([H])C(=C2C(C2=C(C([H])=C([H])C(=C21)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H])=O)O[H])O[H]
Chemical and Physical Properties

Computed Properties

  • Exact Mass: 444.5g/mol
  • Surface Charge: 0
  • XLogP3: 1
  • Hydrogen Bond Donor Count: 8
  • Hydrogen Bond Acceptor Count: 10
  • Rotatable Bond Count: 12
  • Monoisotopic Mass: 444.200885g/mol
  • Monoisotopic Mass: 444.200885g/mol
  • Topological Polar Surface Area: 163Ų
  • Heavy Atom Count: 32
  • Complexity: 571
  • Isotope Atom Count: 0
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Covalently-Bonded Unit Count: 1
  • Tautomer Count: 95
  • Surface Charge: 0

Experimental Properties

  • Stability Shelf Life: Mitoxantrone HCl is not photolabile. Exposure of the product to direct sunlight for one month caused no change in its appearance or potency. Mitoxantrone HCl 0.2 mg/ml in sodium chloride 0.9% in polypropylene syringes is reported to be stable for 28 days at 4 & 20 °C & for 24 hr at 37 °C. Mitoxantrone HCl 2 mg/ml in glass vials & drawn into 12 ml plastic syringes exhibited no visual changes & little or no loss by HPLC when stored for 42 days at 4 & 23 °C. ... Mitoxantrone HCl 0.2 mg/ml in sterile water for injection was stable in Parker Micropump PVC reservoirs for 14 days at 4 & 37 °C, exhibiting no loss by HPLC. Mitoxantrone HCl was cultured with human lymphoblasts to determine whether its cytotoxic activity was retained. The soln retained cytotoxicity for 24 hr at 4 °C & room temp. The pH range of max stability is 2-4.5. Mitoxantrone HCl was unstable when the pH was increased to 7.4.
  • Decomposition: When heated to decomposition it emits toxic fumes of /nitrogen oxides & hydrochloric acid/.
  • LogP: 0.78860
  • PSA: 163.18000
  • Merck: 6217
  • Refractive Index: 1.6500 (estimate)
  • Boiling Point: 805.7°C at 760 mmHg
  • λmax: 670(MeOH)(lit.)
  • Density: 1.3049 (rough estimate)
Security Information
  • Symbol: GHS08 GHS09
  • RTECS:CB5748500
  • WGK Germany:3
  • Safety Instruction:53-36/37/39-45-22
  • Risk Phrases:R46
  • Znak za nevarno blago: T T T+ T+
  • Hazard Statement:H351-H411
  • Warning Statement:P201-P202-P273-P280-P308+P313-P391-P405-P501
  • Prompt:warning
  • Storage Condition:-20°C, protect from light
  • PackingGroup:III
  • Hazard Category Code:46-61-26/27/28
  • Signal Word:Warning
Related Literature
Related Products
Price Data Available
Brand:Mce Supplier:MedChemExpress
No. Purity Stock Specification Price update time operate
HY-13502-10mM*1mLinDMSO 98.36% In-stock 10mM*1mLinDMSO ¥567 26 Jul. 2023
HY-13502-50mg 98.36% In-stock 50mg ¥515 31 Aug. 2023
HY-13502-100mg 98.36% In-stock 100mg ¥744 31 Aug. 2023
HY-13502-10mM*1 mL in DMSO 98.36% In-stock 10mM*1 mL in DMSO ¥567 31 Aug. 2023
Brand:Acmec Supplier:上海吉至生化科技有限公司
No. Purity Stock Specification Price update time operate
M63481-100mg 现货 100mg ¥298.0 27 Apr. 2022
M63481-1g 现货 1g ¥1798.0 27 Apr. 2022
M63480-250mg 98% 现货 250mg ¥523.0 27 Apr. 2022
M63480-1g 98% 现货 1g ¥1599.0 27 Apr. 2022
M63480-100mg 98% 现货 100mg ¥284.0 27 Apr. 2022
M63480-50mg 98% 现货 50mg ¥198.0 27 Apr. 2022
Brand:Key Organics Supplier:Key Organics Ltd
No. Purity Stock Specification Price update time operate
AS-35321-0.25g >95% Usually 15 days 0.25g £256.00/ ¥2,133.56 07 Sep. 2023
AS-35321-1G >95% Usually 15 days 1g £568.00/ ¥4,733.83 07 Sep. 2023
AS-35321-250MG >95% Usually 15 days 0.25 g £265.00/ ¥2,208.56 10 Jul. 2023
Brand:ambeed Supplier:Ambeed
No. Purity Stock Specification Price update time operate
A207951-10mg 98% 中国:9/USA:0 10mg $17.0/ ¥123.47 16 Jun. 2023
A207951-1g 98% 中国:19/USA:5 1g $323.0/ ¥2,346.01 16 Jun. 2023
A207951-1mg 98% 中国:7/USA:2 1mg $6.0/ ¥43.58 16 Jun. 2023
A207951-5g 98% 中国:3/USA:2 5g $1028.0/ ¥7,466.57 16 Jun. 2023
A207951-250mg 98% 中国:26/USA:3 250mg $97.0/ ¥704.53 16 Jun. 2023
A207951-100mg 98% 中国:14/USA:3 100mg $61.0/ ¥443.06 16 Jun. 2023
A207951-50mg 98% 中国:10/USA:0 50mg $42.0/ ¥305.05 16 Jun. 2023
A207951-25mg 98% 中国:-/USA:- 25mg $27.0/ ¥196.11 16 Jun. 2023
Brand:topscience Supplier:上海陶术生物科技有限公司
No. Purity Stock Specification Price update time operate
T6588-1 mL * 10 mM (in DMSO) 98.14% 上海现货 1 mL * 10 mM (in DMSO) ¥385.00 28 Feb. 2022
T6588-200 mg 98.14% 上海现货 200mg ¥1062.00 28 Feb. 2022
T6588-100 mg 98.14% 上海现货 100MG ¥637.00 28 Feb. 2022
T6588-50 mg 98.14% 上海现货 50mg ¥431.00 28 Feb. 2022
T6588-25 mg 98.14% 上海现货 25mg ¥341.00 28 Feb. 2022
T6588-1 mL * 10 mM (in DMSO) 98.14% 上海现货 1 mL * 10 mM (in DMSO) ¥ 373 07 Sep. 2023
T6588-200mg 98.14% 上海现货 200mg ¥ 949 07 Sep. 2023
T6588-100mg 98.14% 上海现货 100mg ¥ 617 07 Sep. 2023
T6588-50mg 98.14% 上海现货 50mg ¥ 418 07 Sep. 2023
T6588-25mg 98.14% 上海现货 25mg ¥ 329 07 Sep. 2023
Brand:安捷凯 Supplier:武汉安捷凯生物医药科技有限公司
No. Purity Stock Specification Price update time operate
ajce49670-100mg 98% 现货 100mg ¥663.00 07 Sep. 2023
ajce49670-50mg 98% 现货 50mg ¥459.00 07 Sep. 2023
Brand:chemscene Supplier:ChemScence
No. Purity Stock Specification Price update time operate
CS-2524-100mg 98.28% In-stock 100mg $96.0/ ¥697.27 26 Apr. 2022
CS-2524-50mg 98.28% In-stock 50mg $60.0/ ¥435.79 26 Apr. 2022
Brand:trc Supplier:TRC
No. Purity Stock Specification Price update time operate
M373425-5g 0.0 5g $1047.00/ ¥7,604.57 17 May. 2023
M373425-1g 0.0 1g $345.00/ ¥2,505.80 17 May. 2023
M373425-500mg 0.0 500mg $ 221.00/ ¥1,605.17 06 Sep. 2023
M373425-300mg 0.0 300mg $178.00/ ¥1,292.85 17 May. 2023
M373425-100mg 0.0 100mg $ 80.00/ ¥581.06 06 Sep. 2023
M373425-50mg 0.0 50mg $ 63.00/ ¥457.58 06 Sep. 2023
Brand:麦克林 Supplier:上海麦克林生化科技有限公司
No. Purity Stock Specification Price update time operate
M869301-1g 97% 上海仓库:现货北方仓库:非现货 1g 2,360.00 17 May. 2021
Brand:九鼎 Supplier:上海贤鼎生物科技有限公司
No. Purity Stock Specification Price update time operate
B-MV437-50mg 98+% 现货 50mg ¥230.0 29 Jul. 2022
B-MV437-10mg 98+% 现货 10mg ¥99.0 29 Jul. 2022
M3133-1G 97.0%(LC) 1~2天 1G ¥3290.0 29 Jul. 2022
M3133-200MG 97.0%(LC) 1~2天 200MG ¥1090.0 29 Jul. 2022
B-MV437-50mg 98+% 现货 50mg ¥193.2 01 Sep. 2023
B-MV437-10mg 98+% 现货 10mg ¥70.3 01 Sep. 2023
M3133-1g 97.0%(LC) 1~2天 1g ¥3290.0 01 Sep. 2023
M3133-200mg 97.0%(LC) 1~2天 200mg ¥1090.0 01 Sep. 2023
Brand:TCI Supplier:梯希爱(上海)化成工业发展有限公司
No. Purity Stock Specification Price update time operate
M3133-1G >95.0%(HPLC) 上海:1/天津:/日本:16 1g ¥2350.00 07 Sep. 2023
M3133-200MG >95.0%(HPLC) 上海:1/天津:1/日本:4 200mg ¥590.00 07 Sep. 2023
Brand:a2bchem Supplier:A2B Chem LLC
No. Purity Stock Specification Price update time operate
AI54485-5g 98% in stock 5g $720.00/ ¥5,229.50 30 Dec. 2023
AI54485-1g >95.0%(HPLC) in stock 1g $185.00/ ¥1,343.69 30 Dec. 2023
AI54485-250mg 98% in stock 250mg $68.00/ ¥493.90 30 Dec. 2023
AI54485-1mg 98% in stock 1mg $5.00/ ¥36.32 30 Dec. 2023
AI54485-100mg 98% in stock 100mg $43.00/ ¥312.32 30 Dec. 2023
AI54485-200mg >95.0%(HPLC) in stock 200mg $62.00/ ¥450.32 30 Dec. 2023
Brand:1pchem Supplier:1PlusChem
No. Purity Stock Specification Price update time operate
1P00IBXX-250mg 98% In Stock USA 250mg $78.00/ ¥566.53 16 Dec. 2023
1P00IBXX-200mg >95.0%(HPLC) In Stock USA 200mg $74.00/ ¥537.48 16 Dec. 2023
1P00IBXX-100mg 98% In Stock USA 100mg $49.00/ ¥355.90 16 Dec. 2023
1P00IBXX-1mg 98% In Stock USA 1mg $5.00/ ¥36.32 16 Dec. 2023
1P00IBXX-5g 98% In Stock USA 5g $848.00/ ¥6,159.19 16 Dec. 2023
1P00IBXX-1g >95.0%(HPLC) In Stock USA 1g $222.00/ ¥1,612.43 16 Dec. 2023
Brand:aaron Supplier:Aaron
No. Purity Stock Specification Price update time operate
AR00IC69-5g 97% In China Stock 5g $934.00/ ¥6,783.83 13 Dec. 2023
AR00IC69-1g 97% In China Stock 1g $228.00/ ¥1,656.01 13 Dec. 2023
AR00IC69-250mg 97% In China Stock 250mg $74.00/ ¥537.48 13 Dec. 2023
AR00IC69-100mg 97% In China Stock 100mg $42.00/ ¥305.05 13 Dec. 2023
AR00IC69-50mg 97% In China Stock 50mg $32.00/ ¥232.42 13 Dec. 2023
AR00IC69-25mg 97% In China Stock 25mg $20.00/ ¥145.26 13 Dec. 2023
Brand:enamine Supplier:Enamine
No. Purity Stock Specification Price update time operate
EN300-117257-250mg Out of Stock 250mg $663.0/ ¥4,815.50 03 Oct. 2023
EN300-117257-100mg Out of Stock 100mg $510.0/ ¥3,704.23 03 Oct. 2023
EN300-117257-50mg Out of Stock 50mg $423.0/ ¥3,072.33 03 Oct. 2023
Brand:scbt Supplier:圣克鲁斯生物技术
No. Purity Stock Specification Price update time operate
sc-207888-100mg ≥97% 100mg ¥2016.00 05 Sep. 2023
sc-207888-100 mg ≥97% 100MG ¥2,016.00 10 Jul. 2023
Brand:enaminestore Supplier:Enamine
No. Purity Stock Specification Price update time operate
EN300-117257-0.25g Out of Stock 0.25g $663.0/ ¥4,815.50 08 Jun. 2023
EN300-117257-0.1g Out of Stock 0.1g $510.0/ ¥3,704.23 08 Jun. 2023
EN300-117257-0.05g Out of Stock 0.05g $423.0/ ¥3,072.33 08 Jun. 2023
The above data is all sourced from the internet. If privacy is violated, please contact us as soon as possible (leave a copy of your company email), and we will take it down for processing! Sorry for any inconvenience caused!
©2008-2024 chem960.com All rights reserved