P-toluenesulfonic acid(4-Methylbenzenesulfonic acid)It is a strong organic acid without oxidation,Acid is
Benzoic acid Million times.White needle or powder crystal,Deliquescent,Soluble in water\Alcohols and other polar solvents.Will make the paper\Carbonization occurs due to dehydration of wood, etc.
Synthetic Circuit 1
1.1
Solvents:
Tetrahydrofuran
;
rt; 10 min, rt
Reference
Manufacture of gel-like thin films and composite membranes for gas separation
,
Japan,
,
,
Synthetic Circuit 2
1.1
Solvents:
Tetrahydrofuran
;
rt
Reference
Monodisperse Cyclic Polymer Mechanochemistry: Scission Kinetics and the Dynamic Memory Effect with Ultrasonication and Ball-Mill Grinding
Noh, Jinkyung
;
Koo, Mo Beom
;
Jung, Jisoo;
Peterson, Gregory I.;
Kim, Kyoung Taek
; et al,
Journal of the American Chemical Society,
2023,
145(33),
18432-18438
Synthetic Circuit 3
Reference
Multifunctional Polymer Nanocarrier for Efficient Targeted Cellular and Subcellular Anticancer Drug Delivery
Babikova, Dimitrina;
Kalinova, Radostina;
Momekova, Denitsa;
Ugrinova, Iva;
Momekov, Georgi; et al,
ACS Biomaterials Science & Engineering,
2019,
5(5),
2271-2283
Synthetic Circuit 4
1.1
Solvents:
Acetonitrile
,
Tetrahydrofuran
;
rt → 37 °C; 33 - 37 °C
Reference
Preparation of N-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-N'-(2-chloro-3-fluorophenyl)urea for treatment of cystic fibrosis
,
World Intellectual Property Organization,
,
,
Synthetic Circuit 5
1.1
Reagents:
Sulfuric acid
(silica supported)
;
30 min, 80 °C
Reference
A novel method for sulfonation of aromatic rings with silica sulfuric acid
Hajipour, Abdol R.; et al,
Tetrahedron Letters,
2004,
45(35),
6607-6609
Synthetic Circuit 6
1.1
Reagents:
Sodium hydroxide
,
Potassium chloride
Catalysts:
Subtilisin
Solvents:
Acetone
,
Water
;
91 h, pH 8.1 - 8.3, 35 - 37 °C
1.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
75 h, pH 2 - 3, rt
2.1
Solvents:
Methanol
;
0.25 h, 25 - 35 °C; 2 h, 50 °C
2.2
Reagents:
Acetic acid
Solvents:
Methanol
;
pH 7.3, 5 °C
3.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879
Synthetic Circuit 7
1.1
Reagents:
Lithium tert-butoxide
Solvents:
Toluene
1.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
2 h, rt
1.3
Reagents:
Sodium hydroxide
Solvents:
Water
2.1
Solvents:
Ethanol
;
2 h, 60 °C; 6 h, 60 °C → 25 °C; 18 h, rt
3.1
Reagents:
Sodium hydroxide
Solvents:
Tetrahydrofuran
,
Water
;
0.75 h, 24 °C; 22 h, 20 °C
4.1
Solvents:
Methanol
;
0.25 h, 25 - 35 °C; 2 h, 50 °C
4.2
Reagents:
Acetic acid
Solvents:
Methanol
;
pH 7.3, 5 °C
5.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879
Synthetic Circuit 8
1.1
Reagents:
Lithium tert-butoxide
Solvents:
Toluene
1.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
2 h, rt
1.3
Reagents:
Sodium hydroxide
Solvents:
tert-Butyl methyl ether
,
Water
;
pH 12 - 13
1.4
overnight, rt; 2 h, 60 °C
2.1
Reagents:
Sodium hydroxide
,
Potassium chloride
Catalysts:
Subtilisin
Solvents:
Acetone
,
Water
;
91 h, pH 8.1 - 8.3, 35 - 37 °C
2.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
75 h, pH 2 - 3, rt
3.1
Solvents:
Methanol
;
0.25 h, 25 - 35 °C; 2 h, 50 °C
3.2
Reagents:
Acetic acid
Solvents:
Methanol
;
pH 7.3, 5 °C
4.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879
Synthetic Circuit 9
1.1
Solvents:
Ethanol
;
2 h, 60 °C; 6 h, 60 °C → 25 °C; 18 h, rt
2.1
Reagents:
Sodium hydroxide
Solvents:
Tetrahydrofuran
,
Water
;
0.75 h, 24 °C; 22 h, 20 °C
3.1
Solvents:
Methanol
;
0.25 h, 25 - 35 °C; 2 h, 50 °C
3.2
Reagents:
Acetic acid
Solvents:
Methanol
;
pH 7.3, 5 °C
4.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879
Synthetic Circuit 10
1.1
Catalysts:
p-Toluenesulfonic acid
Solvents:
Toluene
Reference
Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters as intermediates in the synthesis of perindopril
,
European Patent Organization,
,
,
Synthetic Circuit 11
Reference
Preparation of amino acid-derived intermediates in the synthesis of ACE inhibitors
,
World Intellectual Property Organization,
,
,
Synthetic Circuit 12
Reference
Synthesis, structural, spectroscopic, mechanical, linear and nonlinear optical studies on 4-dimethylaminopyridinium p-toluenesulfonate: A comparative theoretical and experimental investigation
Sivaraj, G.; et al,
Journal of Molecular Structure,
2021,
1240,
Synthetic Circuit 13
1.1
Solvents:
Toluene
;
60 °C; 1 h, 60 °C
Reference
Co-initiated hyperbranched-polydendron building blocks for the direct nanoprecipitation of dendron-directed patchy particles with heterogeneous surface functionality
Hern, F. Y.;
Hill, A.;
Owen, A.;
Rannard, S. P.,
Polymer Chemistry,
2018,
9(14),
1767-1771
Synthetic Circuit 14
Reference
Reversible Photocuring of Liquid Hexa-Anthracene Compounds for Adhesive Applications
Akiyama, Haruhisa;
Okuyama, Yoko;
Fukata, Tamaki;
Kihara, Hideyuki,
Journal of Adhesion,
2018,
94(10),
799-813
Synthetic Circuit 15
1.1
Solvents:
Methanol
,
Benzene
Reference
Highly active oligomeric (salen)Co catalysts for asymmetric epoxide ring-opening reactions
Ready, Joseph M.;
Jacobsen, Eric N.,
Journal of the American Chemical Society,
2001,
123(11),
2687-2688
Synthetic Circuit 16
1.1
Solvents:
Acetonitrile
,
Tetrahydrofuran
;
2 h, 50 - 60 °C; 50 °C → reflux; 70 - 80 °C
Reference
Treatment of cystic fibrosis or the symptoms associatedd with cystic fibrosis
,
United States,
,
,
Synthetic Circuit 17
1.1
Reagents:
Sulfur trioxide
;
58.5 °C
Reference
Study on the sulfonation of toluene with SO3 in microreactor
Chen, Yanquan; et al,
Huaxue Fanying Gongcheng Yu Gongyi,
2013,
29(3),
253-259
Synthetic Circuit 18
1.1
Solvents:
Toluene
;
24 h, reflux
Reference
Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors
Niroula, Doleshwar; et al,
European Journal of Medicinal Chemistry,
2018,
157,
962-977
Synthetic Circuit 19
1.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879
Synthetic Circuit 20
1.1
Reagents:
Triethylamine
,
Sodium sulfate
Solvents:
tert-Butyl methyl ether
;
0.17 h, 5 °C; 24 h, rt
2.1
Reagents:
Lithium tert-butoxide
Solvents:
Toluene
2.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
2 h, rt
2.3
Reagents:
Sodium hydroxide
Solvents:
tert-Butyl methyl ether
,
Water
;
pH 12 - 13
2.4
overnight, rt; 2 h, 60 °C
3.1
Reagents:
Sodium hydroxide
,
Potassium chloride
Catalysts:
Subtilisin
Solvents:
Acetone
,
Water
;
91 h, pH 8.1 - 8.3, 35 - 37 °C
3.2
Reagents:
Hydrochloric acid
Solvents:
Water
;
75 h, pH 2 - 3, rt
4.1
Solvents:
Methanol
;
0.25 h, 25 - 35 °C; 2 h, 50 °C
4.2
Reagents:
Acetic acid
Solvents:
Methanol
;
pH 7.3, 5 °C
5.1
Solvents:
Methanol
;
20 min, rt; 4 h, 40 °C; overnight, rt
Reference
Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Vinyl-ACCA) Derivatives: Key Intermediates for the Preparation of Inhibitors of the Hepatitis C Virus NS3 Protease
Beaulieu, Pierre L.; et al,
Journal of Organic Chemistry,
2005,
70(15),
5869-5879