Circuito Sintético 1
1.1
Reagents:
tert-Butanol
,
Nitrous oxide
Solvents:
Water
;
pH 7
Referência
Radical-based alkylation of guanine derivatives in aqueous medium
Chatgilialoglu, Chryssostomos;
Caminal, Clara;
Mulazzani, Quinto G.,
Organic & Biomolecular Chemistry,
2011,
9(9),
3494-3498
Circuito Sintético 2
1.1
Reagents:
Azobisisobutyronitrile
,
Tributylstannane
Solvents:
Toluene
1.2
Solvents:
Dichloromethane
,
Water
1.3
Reagents:
Tetrabutylammonium fluoride
Solvents:
Tetrahydrofuran
Referência
Preparation of deoxynucleosides via homolytic deoxygenation reactions
,
World Intellectual Property Organization,
,
,
Circuito Sintético 3
1.1
Catalysts:
Purine nucleoside phosphorylase
,
Calcium chloride
Solvents:
Water
Referência
Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside
,
World Intellectual Property Organization,
,
,
Circuito Sintético 4
1.1
Catalysts:
Nucleoside deoxyribosyltransferase
Solvents:
Diethylene glycol
,
Water
;
4 h, pH 6.5, 40 °C
Referência
One-step enzymatic synthesis of nucleosides from low water-soluble purine bases in non-conventional media
Fernandez-Lucas, Jesus;
Fresco-Taboada, Alba;
de la Mata, Isabel;
Arroyo, Miguel,
Bioresource Technology,
2012,
115,
63-69
Circuito Sintético 5
1.1
Reagents:
Monopotassium phosphate
Solvents:
Water
;
1 d, pH 7.1, 60 °C
Referência
Production of nucleosides by immobilized Escherichia coli cells expressing uridine phosphorylase and purine nucleoside phosphorylase
,
European Patent Organization,
,
,
Circuito Sintético 6
1.1
Reagents:
Methylamine
Solvents:
Water
Referência
The thermal N9/N7 isomerization of N2-acylated 2'-deoxyguanosine derivatives in the melt and in solution
Golankiewicz, Bozenna;
Ostrowski, Tomasz;
Leonard, Peter;
Seela, Frank,
Helvetica Chimica Acta,
2002,
85(1),
388-398
Circuito Sintético 7
1.1
Reagents:
Sodium hydroxide
,
Hydrochloric acid
Catalysts:
Nucleoside deoxyribosyltransferase
Solvents:
Water
;
16 h, pH 6 - 6.3, 40 °C
1.2
Reagents:
Sodium hydroxide
Solvents:
Water
1.3
Reagents:
Sodium hydroxide
,
Hydrochloric acid
Catalysts:
Adenosine deaminase
Solvents:
Water
;
13 h, 7.8 atm, 40 °C
1.4
Reagents:
Sodium hydroxide
Solvents:
Water
;
2 min, reflux
Referência
Enzymatic synthesis of 2'-deoxyguanosine with nucleoside deoxyribosyltransferase-II
Okuyama, Kiyoshi;
Shibuya, Susumu;
Hamamoto, Tomoki;
Noguchi, Toshitada,
Bioscience,
2003,
67(5),
989-995
Circuito Sintético 8
Referência
Synthesis of 9-β-D-arabinofuranosylguanine by combined use of two whole cell biocatalysts
Medici, Rosario;
Iribarren, Adolfo M.;
Lewkowicz, Elizabeth S.,
Bioorganic & Medicinal Chemistry Letters,
2009,
19(15),
4210-4212
Circuito Sintético 9
1.1
Catalysts:
Adenosine deaminase
Solvents:
Dimethyl sulfoxide
,
Water
;
24 h, pH 7.4, rt
Referência
Synthesis of 2'-deoxyguanosine from 2'-deoxyadenosine via C2 nitration
Xia, Ran;
Chen, Lei-Shan;
Xu, Shao-Hong;
Xia, Chao;
Sun, Li-Ping,
Nucleosides,
2022,
41(7),
593-604
Circuito Sintético 10
1.1
Reagents:
Sodium hydroxide
Solvents:
Water
Referência
Enzymic manufacture of glyoxal-guanosines and preparation of guanosines from them
,
Japan,
,
,
Circuito Sintético 11
1.1
Reagents:
Sodium hydroxide
Referência
Modification of guanine bases: reaction of guanine nucleosides with aryl and chlorosulfonyl isocyanates
Camus, Philippe;
Lhomme, M. France;
Lhomme, Jean,
Tetrahedron Letters,
1989,
30(4),
467-70
Circuito Sintético 12
1.1
Reagents:
Potassium carbonate
,
Monopotassium phosphate
Solvents:
Water
;
pH 10, 45 °C
1.2
Reagents:
Sodium hydroxide
Solvents:
Water
;
pH 10, 45 °C
1.3
Catalysts:
Purine nucleoside phosphorylase
(immobilized onto glyoxal agarose gel)
,
Uridine phosphorylase
(immobilized onto Sepabeads coated with polyethyleneamine followed by crosslinking with aldehyde-dextran)
;
45 °C
1.4
Reagents:
Hydrochloric acid
Solvents:
Water
;
24 h, pH 10, 45 °C
1.5
Reagents:
Potassium carbonate
Solvents:
Water
;
pH 10, rt → 4 °C
1.6
Reagents:
Hydrochloric acid
Solvents:
Water
Referência
Synthesis of 2'-deoxynucleosides by transglycosylation with new immobilized and stabilized uridine phosphorylase and purine nucleoside phosphorylase
Ubiali, Daniela;
Rocchietti, Silvia;
Scaramozzino, Francesca;
Terreni, Marco;
Albertini, Alessandra M.; et al,
Advanced Synthesis & Catalysis,
2004,
346(11),
1361-1366
Circuito Sintético 13
1.1
Catalysts:
Purine nucleoside phosphorylase
(immobilized)
Solvents:
Water
;
8 h, pH 10, 45 °C
Referência
Immobilization and Stabilization of Recombinant Multimeric Uridine and Purine Nucleoside Phosphorylases from Bacillus subtilis
Rocchietti, Silvia;
Ubiali, Daniela;
Terreni, Marco;
Albertini, Alessandra M.;
Fernandez-Lafuente, Roberto; et al,
Biomacromolecules,
2004,
5(6),
2195-2200
Circuito Sintético 14
1.1
Catalysts:
Adenosine deaminase
Referência
Nucleic acid related compounds. 96. Synthesis of sugar-modified 2,6-diaminopurine and guanine nucleosides from guanosine via transformations of 2-aminoadenosine and enzymic deamination with adenosine deaminase
Robins, Morris J.;
Zou, Ruiming;
Hansske, Fritz;
Wnuk, Stanislaw F.,
Canadian Journal of Chemistry,
1997,
75(6),
762-767
Circuito Sintético 15
1.1
Reagents:
Sodium hydroxide
Catalysts:
Purine nucleoside phosphorylase
Solvents:
Water
Referência
Process for producing nucleoside compound
,
World Intellectual Property Organization,
,
,