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HPOB | 1429651-50-2
Productnaam:HPOB
CAS-nummer:1429651-50-2
MF:C17H18N2O4
MDL:MFCD27952937
CID:2084783
Onderzoek
Inleiding
Naam en identificatie
Chemische en fysische eigenschappen
Beveiligingsinformatie
Gerelateerde literatuur
Inleiding
Hpob is a highly potent \ selective HDAC6 inhibitor with an IC50 of 56 nm Hpob showed more than 30 times lower potency against other HDACs Conclusion: hpob can improve the effectiveness of DNA damage anticancer active molecules in transformed cells Hpob did not block the ubiquitin binding activity of HDAC6
Naam en identificatie
- HPOB
- Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-
- 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide
- MDL：MFCD27952937
- InChIKey：RFAZNTABYJYOAR-UHFFFAOYSA-N
- Inchi：InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
- SMILES：O=C(N(CCO)C1=CC=CC=C1)CC2=CC=C(C(NO)=O)C=C2
Chemische en fysische eigenschappen
Berekende eigenschappen
- Aantal waterstofbonddonors: 3
- Aantal waterstofbondacceptatoren: 4
- Aantal draaibare bindingen: 8
- Zware atoomtelling: 23
Experimentele eigenschappen
- Oplosbaarheid: DMSO: soluble1mg/mL, clear (warmed)
Beveiligingsinformatie
- WGK Duitsland：3
- Vervoersnummer gevaarlijk materiaal：NONH for all modes of transport
- Gevaarverklaring：H302-H315-H319-H335
- Waarschuwingsverklaring：P261-P305+P351+P338
- Opslagvoorwaarde：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Signaalwoord：Warning
Gerelateerde literatuur
- 1. Biomedical applications of natural-based polymers combined with bioactive glass nanoparticles á. J. Leite,J. F. Mano J. Mater. Chem. B 2017 5 4555
- 2. Next-generation of selective histone deacetylase inhibitors Feifei Yang,Na Zhao,Di Ge,Yihua Chen RSC Adv. 2019 9 19571
-
3.Evaluation of a drinking water treatment process involving directly recycling filter backwash water using physico-chemical analysis and toxicity assay
Bingwei Hou,Tao Lin,Wei Chen RSC Adv. 2016 6 76922 -
4.Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity
Nina Re?ing,Viktoria Marquardt,Christoph G. W. Gertzen,Andrea Sch?ler,Alexander Schramm,Thomas Kurz,Holger Gohlke,Achim Aigner,Marc Remke,Finn K. Hansen Med. Chem. Commun. 2019 10 1109 -
5.290. The vapour pressure of chlorine heptoxide
C. F. Goodeve,J. Powney J. Chem. Soc. 1932 2078 -
6.Contents pages
J. Chem. Soc. Perkin Trans. 2 1972 P031 - 7. Assessing the potential of fluorescence spectroscopy to monitor contaminants in source waters and water reuse systems Joseph Wasswa,Natalie Mladenov,William Pearce Environ. Sci.: Water Res. Technol. 2019 5 370
- 8. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
-
9.In silico design of novel benzohydroxamate-based compounds as inhibitors of histone deacetylase 6 based on 3D-QSAR, molecular docking, and molecular dynamics simulations
Han Chu,Qing-xiu He,Juan Wang,Yong Hu,Yuan-qiang Wang,Zhi-hua Lin New J. Chem. 2020 44 21201
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