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Nexturastat A | 1403783-31-2
Productnaam:Nexturastat A
CAS-nummer:1403783-31-2
MF:C19H23N3O3
MDL:MFCD28099804
CID:2083584
Onderzoek
Inleiding
Naam en identificatie
Chemische en fysische eigenschappen
Beveiligingsinformatie
Gerelateerde literatuur
Inleiding
Nexturastat A is a potent and selective HDAC6 inhibitor Nexturastat a inhibited HDAC6 with an IC50 of 5 nm Nexturastat a can be used in the study of multiple myeloma (mm)
Naam en identificatie
- 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
- Nexturastat A
- NexturastatA
- S7473
- Nexturastat A
- 4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide
- AK175589
- 4-{[butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide
- nexturastat-a
- N4R
- GTPL7504
- AOB6618
- HMS3750M11
- HMS3653J07
- BCP09960
- BDBM50398716
- 2584AH
- SW220090-1
- B3704
- A14032
- Benzamide, 4-[[butyl
- MDL：MFCD28099804
- InChIKey：JZWXMCPARMXZQV-UHFFFAOYSA-N
- Inchi：1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
- SMILES：O=C(N([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N(C([H])([H])C1C([H])=C([H])C(C(N([H])O[H])=O)=C([H])C=1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
Chemische en fysische eigenschappen
Berekende eigenschappen
- Exacte massa: 341.17400
- Aantal waterstofbonddonors: 3
- Aantal waterstofbondacceptatoren: 3
- Aantal draaibare bindingen: 7
- Zware atoomtelling: 25
- Complexiteit: 416
- Topologisch pooloppervlak: 81.7
Experimentele eigenschappen
- LogboekP: 4.04430
- PSA: 85.16000
- Oplosbaarheid: Very slightly soluble (0.13 g/l) (25 º C),
- Dichtheid: 1.228±0.06 g/cm3 (20 ºC 760 Torr),
Beveiligingsinformatie
- Gevaarverklaring：H302
- Waarschuwingsverklaring：P280-P305+P351+P338
- Opslagvoorwaarde：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Signaalwoord：Warning
Gerelateerde literatuur
-
1.PROTAC chemical probes for histone deacetylase enzymes
Urvashi Patel,Joshua P. Smalley,James T. Hodgkinson RSC Chem. Biol. 2023 4 623 -
2.Chemically induced degradation of epigenetic targets
Md Kabir,Xufen Yu,H. ümit Kaniskan,Jian Jin Chem. Soc. Rev. 2023 52 4313 - 3. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 4. Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides D. Wutz,D. Gluhacevic,A. Chakrabarti,K. Schmidtkunz,D. Robaa,F. Erdmann,C. Romier,W. Sippl,M. Jung,B. K?nig Org. Biomol. Chem. 2017 15 4882
- 5. Plasticity in designing PROTACs for selective and potent degradation of HDAC6 Haiyan Yang,Wenxing Lv,Ming He,Haiteng Deng,Haitao Li,Wei Wu,Yu Rao Chem. Commun. 2019 55 14848
- 6. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs Mohd. Muddassir,Kunjal Soni,Chetan B. Sangani,Abdullah Alarifi,Mohd. Afzal,Naaser A. Y. Abduh,Yongtao Duan,Poonam Bhadja RSC Adv. 2021 11 612
- 7. Development of the first non-hydroxamate selective HDAC6 degraders Tim Keuler,Beate K?nig,Nico Bückrei?,Fabian B. Kraft,Philipp K?nig,Linda Sch?ker-Hübner,Christian Steinebach,Gerd Bendas,Michael Gütschow,Finn K. Hansen Chem. Commun. 2022 58 11087
- 8. Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors D. Diedrich,A. Hamacher,C. G. W. Gertzen,L. A. Alves Avelar,G. J. Reiss,T. Kurz,H. Gohlke,M. U. Kassack,F. K. Hansen Chem. Commun. 2016 52 3219
-
9.Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition
Yves Depetter,Silke Geurs,Flore Vanden Bussche,Rob De Vreese,Jorick Franceus,Tom Desmet,Olivier De Wever,Matthias D'hooghe Med. Chem. Commun. 2018 9 1011 -
10.Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities
Ji Liu,Tingting Wang,Xinyang Wang,Lin Luo,Jing Guo,Yanfu Peng,Qibing Xu,Jiefei Miao,Yanan Zhang,Yong Ling Med. Chem. Commun. 2017 8 1213
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(CAS:1403783-31-2)Nexturastat AOrdernummerin Stock/in Stock/in Stock99%/99%/99%100mg/250mg/1gOnderzoek/Onderzoek/Onderzoek30 August 2024Product Introduction Product Official Link
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| T1819-25mg | 99.57% | 上海现货 | 25mg | ￥ 5510 | 07 Sep. 2023 | ||
| T1819-10mg | 99.57% | 上海现货 | 10mg | ￥ 3256 | 07 Sep. 2023 | ||
| T1819-5mg | 99.57% | 上海现货 | 5mg | ￥ 1892 | 07 Sep. 2023 | ||
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