b−グルコステロール(b−グルコステロール)、アッカ(3 b)-Stigmasterol-5-エン-3-オールはい植物ステロール類それは1類の成分で、4環トリテルペン類の化合物に属して、広範に各種の天然植物の中で存在しますしょくぶつゆ\ナッツ他の植物種子においても、いくつかの植物薬で発見されている。現在、β−グルコステロールはその独特な生物学的および理化学的性質のため、製薬業界で広く使用されている。特に、研究により、β−グルコステロールの摂取は人々の多くの慢性病の発症率と関係があることが明らかになった。研究によると、血清を著しく低下させることができるコレステロール効果:コレステロールの代わりにリポソーム膜材料とすることができる。
ごうせいかいろ 1
1.1
Reagents:
Aluminum iodide
Solvents:
Acetonitrile
,
Dichloromethane
;
10 min, rt
1.2
Reagents:
Sodium thiosulfate
Solvents:
Water
2.1
Reagents:
Potassium carbonate
Solvents:
Methanol
,
Dichloromethane
;
12 h, rt
リファレンス
A concise synthesis of β-sitosterol and other phytosterols
Hang, Jiliang; et al,
Steroids,
2010,
75(12),
879-883
ごうせいかいろ 2
1.1
Reagents:
Sulfuric acid
Solvents:
Water
;
5 h, reflux
リファレンス
β-sitosterol-3-O-β-D-xylopyranosyl (1→4)-O-β-D-glucopyranoside from the seeds of Zanthoxylum hamiltonianum Wall
Rajpoot, Sandhya,
International Journal of Chemical Sciences,
2013,
11(2),
1131-1136
ごうせいかいろ 3
1.1
Catalysts:
Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O)
Solvents:
Methanol
リファレンス
Montmorillonite clays catalysis. IX. A mild and efficient method for removal of tetrahydropyranyl ethers
Li, Tong-Shuang; et al,
Synthetic Communications,
1999,
29(2),
181-188
ごうせいかいろ 4
1.1
Reagents:
Ethanol
Catalysts:
μ4-Oxohexakis[μ-(2,2,2-trifluoroacetato-κO:κO′)]tetrazinc
;
96 h, reflux
リファレンス
A tetranuclear-zinc-cluster-catalyzed practical and versatile deprotection of acetates and benzoates
Iwasaki, Takanori; et al,
Chemistry - A European Journal,
2010,
16(38),
11567-11571
ごうせいかいろ 5
リファレンス
Phytochemical study of privet (Ligustrum vulgare L.)
Diak, J.,
Herba Polonica,
1988,
34(3),
103-8
ごうせいかいろ 6
1.1
Reagents:
Hydrochloric acid
,
Water
Solvents:
Water
リファレンス
Constituents of the roots of Boerhaavia diffusa L. I. Examination of sterols and structures of new rotenoids, boeravinones A and B
Kadota, Shigetoshi; et al,
Chemical & Pharmaceutical Bulletin,
1989,
37(12),
3214-20
ごうせいかいろ 7
1.1
Reagents:
Hydrogen
Catalysts:
Palladium
Solvents:
Methanol
,
Dichloromethane
;
24 h, 200 psi, 23 °C
1.2
Catalysts:
p-Toluenesulfonic acid
Solvents:
1,4-Dioxane
,
Water
;
3 h, 80 °C
リファレンス
Identification and characterization of β-sitosterol target proteins
Lomenick, Brett; et al,
Bioorganic & Medicinal Chemistry Letters,
2015,
25(21),
4976-4979
ごうせいかいろ 8
1.1
Catalysts:
Palladium
Solvents:
Ethanol
;
16 h, 50 psi, rt
1.2
Reagents:
p-Toluenesulfonic acid
Solvents:
1,4-Dioxane
,
Water
;
3 h, 80 °C
リファレンス
Synthesis, isolation and characterization of β-sitosterol and β-sitosterol oxide derivatives
McCarthy, Florence O.; et al,
Organic & Biomolecular Chemistry,
2005,
3(16),
3059-3065
ごうせいかいろ 9
1.1
Solvents:
Acetic acid
;
2 h, reflux
2.1
Reagents:
Potassium hydroxide
Solvents:
Diethyl ether
,
Methanol
;
15 h, rt
リファレンス
Practical and facile route to a functional intermediate from stigmasterol for the synthesis of 1α-hydroxyvitamin D5 and related compounds
Takahashi, Michiyasu; et al,
Heterocycles,
2016,
93(1),
101-113
ごうせいかいろ 10
1.1
Catalysts:
p-Toluenesulfonic acid
Solvents:
1,4-Dioxane
,
Water
;
3 h, 80 °C
リファレンス
Identification and characterization of β-sitosterol target proteins
Lomenick, Brett; et al,
Bioorganic & Medicinal Chemistry Letters,
2015,
25(21),
4976-4979
ごうせいかいろ 11
リファレンス
Configurations at C-24 of 24-alkylsterols from Clerodendrum infortunatum Linn
Thakur, Swapnadip; et al,
Indian Journal of Chemistry,
1988,
(1),
17-20
ごうせいかいろ 12
リファレンス
Isolation and structure of isopropyl-α-D-glucoside from the coral Sclerophytum capitalis
Sharma, Perveen; et al,
Journal of Natural Products,
1989,
52(2),
395-7
ごうせいかいろ 13
1.1
Reagents:
Potassium hydroxide
Solvents:
Ethanol
,
Water
;
8 h, reflux
リファレンス
Phytosterol and γ-Oryzanol Conjugates: Synthesis and Evaluation of their Antioxidant, Antiproliferative, and Anticholesterol Activities
Lesma, Giordano; et al,
Journal of Natural Products,
2018,
81(10),
2212-2221
ごうせいかいろ 14
1.1
Reagents:
Potassium carbonate
Solvents:
Methanol
,
Dichloromethane
;
12 h, rt
リファレンス
A concise synthesis of β-sitosterol and other phytosterols
Hang, Jiliang; et al,
Steroids,
2010,
75(12),
879-883
ごうせいかいろ 15
リファレンス
Sterols of Salsola collina
Syrchina, A. I.; et al,
Khimiya Prirodnykh Soedinenii,
1989,
(5),
731-2
ごうせいかいろ 16
リファレンス
Synthesis of triaromatic steroid hydrocarbons methylated at position 2, 3, or 6: molecular fossils of yet unknown biological origin
Lechtfouse, Eric; et al,
Tetrahedron,
1994,
50(6),
1731-44
ごうせいかいろ 17
1.1
Reagents:
Potassium hydroxide
Solvents:
Diethyl ether
,
Methanol
;
15 h, rt
リファレンス
Practical and facile route to a functional intermediate from stigmasterol for the synthesis of 1α-hydroxyvitamin D5 and related compounds
Takahashi, Michiyasu; et al,
Heterocycles,
2016,
93(1),
101-113
ごうせいかいろ 18
1.1
Reagents:
Pyridine
Solvents:
Methanol
;
6 h, reflux
2.1
Catalysts:
Palladium
Solvents:
Ethanol
;
16 h, 50 psi, rt
2.2
Reagents:
p-Toluenesulfonic acid
Solvents:
1,4-Dioxane
,
Water
;
3 h, 80 °C
リファレンス
Synthesis, isolation and characterization of β-sitosterol and β-sitosterol oxide derivatives
McCarthy, Florence O.; et al,
Organic & Biomolecular Chemistry,
2005,
3(16),
3059-3065
ごうせいかいろ 19
1.1
Reagents:
Chlorotrimethylsilane
,
Potassium fluoride (KF), dihydrate
Solvents:
Acetonitrile
;
20 min, 60 °C
1.2
Reagents:
Sodium bicarbonate
Solvents:
Water
;
rt
リファレンス
A mild and efficient desilylation of O-tert-butyldimethylsilyl ethers mediated by chlorotrimethylsilane and potassium fluoride dihydrate in acetonitrile
Peng, Yu; et al,
Synlett,
2006,
(8),
1165-1168
ごうせいかいろ 20
1.1
Reagents:
Potassium acetate
Solvents:
Methanol
;
3 h, reflux
2.1
Reagents:
Hydrogen
Catalysts:
Palladium
Solvents:
Methanol
,
Dichloromethane
;
24 h, 200 psi, 23 °C
2.2
Catalysts:
p-Toluenesulfonic acid
Solvents:
1,4-Dioxane
,
Water
;
3 h, 80 °C
リファレンス
Identification and characterization of β-sitosterol target proteins
Lomenick, Brett; et al,
Bioorganic & Medicinal Chemistry Letters,
2015,
25(21),
4976-4979