Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry†

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [¹¹C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.