Nome del prodotto：Olanzapine

Proprietà calcolate

• Massa esatta: 312.4g/mol
• Carica superficiale: 0
• XLogP3: 2.9
• Conta donatori di obbligazioni idrogeno: 1
• Conta accettatore di obbligazioni idrogeno: 4
• Conta legami ruotabili: 1
• Massa monoisotopica: 312.140868g/mol
• Massa monoisotopica: 312.140868g/mol
• Superficie polare topologica: 59.1Ų
• Conta atomi pesanti: 22
• Complessità: 432
• Conta atomi isotopi: 0
• Conto di stereocentri atomici definito: 0
• Conta stereocentri atomici non definiti: 0
• Conto stereocentrico definito delle obbligazioni: 0
• Conto stereocenter di bond non definito: 0
• Conteggio di unità legate in modo Covalent: 1
• Superficie polare topologica: 56.2
• Conta atomi isotopi: 0
• Conta Tautomer: 3
• Carica superficiale: 0

Proprietà sperimentali

• Decomposition: When heated to decomposition it emits toxic fumes of /nitrogen oxides and sulfur oxides/.
• Dissociation Constants：pKa1 = 4.01; pKa2 = 7.24; pKa3 = 14.17 (est)
• LogP: 2.88860
• PSA: 59.11000
• Merck: 6822
• Indice di rifrazione: 3.3
• Punto di infiammabilità: Fahrenheit: 35,6 ° f
  Celsius: 2 ° c
  
• Colore/forma: 1.0 mg/mL in acetonitrile
• Sensibilità: Sensibile al calore
• Densità: 1.32

• Simbolo: GHS07
• RTECS：XJ9007750
• WGK Germania：3
• Istruzioni di sicurezza：S22; S24/25
• Segno di merci pericolose： F Xn
• Numero di trasporto dei materiali pericolosi：UN 2811 6.1 / PGIII
• Dichiarazione di pericolo：H315-H319-H413
• Dichiarazione di avvertimento：P305 + P351 + P338
• Prompt：pericoloso
• Condizioni di conservazione：4°C, protect from light
• PackingGroup：III
• Codice categoria di pericolo：11-20/21/22-36
• Parola segnale：Warning
• Classe di pericolo：6.1

• Dati doganali：

  Codice doganale cinese:

  2934999090

  Panoramica:

  293499990. Altri composti eterociclici. IVA: 17,0%. Tasso di rimborso delle tasse: 13,0%. Condizioni normative: niente. Tariffa MFN:6,5%. Tariffa generale:20,0%

  Elementi di dichiarazione:

  Nome del prodotto, contenuto del componente, uso per

  Riassunto:

  293499990. altri composti eterociclici. IVA:17,0%. Aliquota di sconto fiscale:13,0%. Tariffa MFN:6,5%. Tariffa generale:20,0%

• 1. Eco-friendly synthesis of new olanzapine derivatives and evaluation of their anticancer potential Anna K. Drabczyk,Damian Ku?aga,Przemys?aw Zar?ba,Wiktoria Tylińska,Wojciech Bachowski,Aneta Archa?a,Artur Wnorowski,Andromachi Tzani,Anastasia Detsi,Jolanta Ja?kowska RSC Adv. 2023 13 20467
• 2. A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring Yiran Fan,Guanghu Shen,Ping Li,Xiaonan Xi,Haiting Wu,Hongjun Tian,Yaxin Lu,Zheng Yin RSC Adv. 2015 5 34342
• 3. Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release Sina Farzaneh,Ebadullah Asadi,Majid Abdouss,Azam Barghi-Lish,Saman Azodi-Deilami,Hossein Ali Khonakdar,Mehdi Gharghabi RSC Adv. 2015 5 9154
• 4. Sensitive UHPLC-MS/SRM method for quantifying olanzapine metabolites and degradation products from sera Kannan Rangiah Anal. Methods 2014 6 5250
• 5. Studies on photodegradation of levomepromazine and olanzapine under simulated environmental conditions Joanna Karpińska,Aneta Sokó?,Anna Bernatowicz,Aneta Szul?cka,Urszula Kotowska Photochem. Photobiol. Sci. 2012 11 1575
• 6. Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors Dhilli Rao Gorja,Soumita Mukherjee,Chandana Lakshmi T. Meda,Girdhar Singh Deora,K. Lalith Kumar,Ankit Jain,Girish H. Chaudhari,Keerthana S. Chennubhotla,Rakesh K. Banote,Pushkar Kulkarni,Kishore V. L. Parsa,K. Mukkanti,Manojit Pal Org. Biomol. Chem. 2013 11 2075
• 7. Crystal-energy landscapes of active pharmaceutical ingredients using composite approaches Luc M. LeBlanc,Erin R. Johnson CrystEngComm 2019 21 5995
• 8. Growing crystals by design: general discussion Michael Anderson,Matthew Bennett,Ruel Cedeno,Marta K. Dudek,Kristen Fichthorn,Aaron R. Finney,Ian Ford,Colin Freeman,Alan Hare,Connor Hewson,Adam Hill,Joonsoo Kim,Christine Kirschhock,Christian Kuttner,Fiona Meldrum,Sten O. Nilsson Lill,Rachel Pooley,Ivo B. Rietveld,Jeffrey Rimer,Kevin Roberts,Jutta Rogal,Matteo Salvalaglio,Jan Sefcik,Wenhao Sun,Damien Thompson,Jincheng Tong,Mollie Trueman,Peter Vekilov Faraday Discuss. 2022 235 383
• 9. Designing a new cocrystal of olanzapine drug and observation of concomitant polymorphism in a ternary cocrystal system Jagadeesh Babu Nanubolu,Krishnan Ravikumar CrystEngComm 2017 19 355
• 10. Influence of crystal packing on the thermal properties of cocrystals and cocrystal solvates of olanzapine: insights from computations Anuja Venkata Sai Durga Surampudi,Satyasree Rajendrakumar,Jagadeesh Babu Nanubolu,Sridhar Balasubramanian,Artem O. Surov,Alexander P. Voronin,German L. Perlovich CrystEngComm 2020 22 6536

• 
  1-Benzhydrylpiperazine Numero CAS.: 841-77-0
• 
  1,2-Dimethylhydrazine dihydrochloride Numero CAS.: 306-37-6
• 
  1-Methylpiperazine Numero CAS.: 109-01-3
• 
  Methyl Salicylate Numero CAS.: 119-36-8
• 
  1-Fluoro-2-nitrobenzene Numero CAS.: 1493-27-2
• 
  Olanzapine-methyl-d3 Numero CAS.: 786686-79-1
• 
  Tribenuron Methyl Numero CAS.: 101200-48-0
• 
  Ethanone,1-[5-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,4]benzodiazepin-2-yl]- Numero CAS.: 74162-56-4
• 
  5,10-Dihydro-2-methyl-4H-thieno[2,3-b][1,5]benzodiazepine-4-thione (Olanzapine Impurity) Numero CAS.: 612507-13-8
• 
  b-D-Glucopyranuronic acid,1-deoxy-1-[2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepin-10-yl]- Numero CAS.: 186792-80-3