colorless liquid ,Slight smell.Miscible with water,Miscible in alcohol\aromatic hydrocarbon\ester\Hydrocarbons\Organic solvents such as oils.inflammable,meetOxidizing agentExplosive.For spices\food,Also used as solvent.It is usually obtained by esterification of lactic acid and ethanol in sulfuric acid.
Synthetic Circuit 1
1.1
Reagents:
Hydrogen
Catalysts:
Rhodium(1+), bis[(2,3,5,6-η)-bicyclo[2.2.1]hepta-2,5-diene]-, tetrafluoroborate(…
,
Ferrocene, 1,1′-bis(diphenylphosphino)-2,2′-bis[(1S)-1-[(diphenylphosphino)methy…
Solvents:
Ethanol
;
16 h, 20 atm, 25 °C
Reference
Preparation of tetradentate ferrocenophosphine ligands and their use as enantioselective hydrogenation catalysts
,
World Intellectual Property Organization,
,
,
Synthetic Circuit 2
1.1
Reagents:
Hydrogen
Catalysts:
Poly[nitrilo(dimethylphosphoranylidyne)]
,
[(1,2,5,6-η)-1,5-Cyclooctadiene][(1,2,3,4,5,6-η)-1,3,5-cyclooctatriene]ruthenium
Solvents:
Tetrahydrofuran
;
10 h, 1 atm, 45 °C
1.2
Solvents:
Ethanol
;
6 h, 1 atm, 25 °C
Reference
Supported ruthenium nanoparticles on polyorganophosphazenes: preparation, structural and catalytic studies
Spitaleri, Andrea;
Pertici, Paolo;
Scalera, Nico;
Vitulli, Giovanni;
Hoang, Manh; et al,
Inorganica Chimica Acta,
2003,
352,
61-71
Synthetic Circuit 3
1.1
Reagents:
Methanamine, tetrahydrofluoride
Solvents:
Methanol
Reference
Methylammonium fluoride (MAF): a convenient reagent for silicon-oxygen bond cleavage
Solladie-Cavallo, A.;
Khiar, N.,
Synthetic Communications,
1989,
19(7-8),
1335-40
Synthetic Circuit 4
1.1
Reagents:
Hydrogen
Catalysts:
Platinum
Solvents:
Toluene
;
6 h, 100 psi, 25 °C
Reference
Enantioselective hydrogenation of α-ketoesters over alkaloid-modified platinum nanowires
Erathodiyil, Nandanan;
Gu, Hongwei;
Shao, Huilin;
Jiang, Jiang;
Ying, Jackie Y.,
Green Chemistry,
2011,
13(11),
3070-3074
Synthetic Circuit 5
1.1
Catalysts:
Tin(II) triflate
Solvents:
Ethanol
;
4 h, 140 °C
1.2
Reagents:
Sodium bicarbonate
Solvents:
Water
;
neutralized
Reference
Understanding the role of the substrate and the metal triflate acidic catalyst in sugar platform biorefineries: A comprehensive systematic approach to catalytic transformations of (poly)carbohydrates in ethanol
Bodachivskyi, Iurii;
Kuzhiumparambil, Unnikrishnan;
Williams, D. Bradley G.,
Chemical Engineering Journal (Amsterdam,
2020,
(2020),
Synthetic Circuit 6
1.1
30 min, 45 °C
1.2
Catalysts:
Silicic acid (H4SiO4), tetraethyl ester, polymer with triethoxymethylsilane
;
rt; 6 h, 90 °C
Reference
Mesoporous Methyl-Functionalized Sn-Silicates Generated by the Aerosol Process for the Sustainable Production of Ethyl Lactate
Vivian, Alvise;
Fusaro, Luca;
Debecker, Damien P.
;
Aprile, Carmela,
ACS Sustainable Chemistry & Engineering,
2018,
6(11),
14095-14103
Synthetic Circuit 7
1.1
Reagents:
Hydrogen
Catalysts:
Iridium
(nanoparticles)
;
2.5 h, 4 atm, 75 °C
Reference
Iridium nanoparticles prepared in ionic liquids: An efficient catalytic system for the hydrogenation of ketones
Fonseca, Gledison S.;
Scholten, Jackson D.;
Dupont, Jairton,
Synlett,
2004,
(9),
1525-1528
Synthetic Circuit 8
1.1
Catalysts:
Sulfuric acid
Solvents:
Ethanol
;
2 h, 150 °C
Reference
Separation of lactic acid from diluted solution by hybrid short path evaporation and reactive distillation
Komesu, Andrea;
Rocha de Oliveira, Johnatt Allan;
Maciel, Maria Regina Wolf;
Maciel Filho, Rubens,
Journal of Chemistry and Chemical Engineering,
2016,
10(6),
271-276
Synthetic Circuit 9
1.1
Reagents:
Hydrogen
Catalysts:
Ruthenium
,
6A-[4-[[[(2S)-2-Amino-4-methyl-1-oxopentyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-…
(methylated)
Solvents:
Water
;
6 h, 20 bar, rt
Reference
β-Cyclodextrins grafted with chiral amino acids: A promising supramolecular stabilizer of nanoparticles for asymmetric hydrogenation?
Chau, Nguyet Trang Thanh;
Guegan, Jean-Paul;
Menuel, Stephane;
Guerrero, Miguel;
Hapiot, Frederic; et al,
Applied Catalysis,
2013,
(2013),
497-503
Synthetic Circuit 10
1.1
Reagents:
Hydrogen
Catalysts:
4-(3-Phenylpropyl)pyridine
,
Ruthenium
(complex stabilization with substituted pyridine)
,
Carbon
,
[(1,2,5,6-η)-1,5-Cyclooctadiene][(1,2,3,4,5,6-η)-1,3,5-cyclooctatriene]ruthenium
Solvents:
Ethanol
;
2.5 h, 40 bar, 50 °C
Reference
Ruthenium nanoparticles supported on multi-walled carbon nanotubes: Highly effective catalytic system for hydrogenation processes
Jahjah, Mohamad;
Kihn, Yolande;
Teuma, Emmanuelle;
Gomez, Montserrat,
Journal of Molecular Catalysis A: Chemical,
2010,
332(1-2),
106-112
Synthetic Circuit 11
1.1
Reagents:
Cinchonidine
,
Hydrogen
Catalysts:
Ruthenium
,
Poly[(2R)-1-oxo-2-phenyl-1,3-propanediyl]
Solvents:
Ethanol
;
1 h, 40 bar, rt
Reference
Stabilization of Pd, Pt and Ru nanoparticles by optically active CO/styrene copolymers
Favier, Isabelle;
Picurelli, David;
Pradel, Christian;
Durand, Jerome;
Milani, Barbara; et al,
Inorganic Chemistry Communications,
2010,
13(6),
766-768
Synthetic Circuit 12
1.1
Solvents:
Water
;
2 h, 80 °C
Reference
Alkyl carboxylate preparation method and preparation apparatus
,
Korea,
,
,
Synthetic Circuit 13
1.1
Solvents:
Ethanol
;
0.5 h, 45 °C; rt; 6 h, 90 °C
Reference
Selective conversion of trioses to lactates over Lewis acid heterogeneous catalysts
Li, Li;
Stroobants, Christophe;
Lin, Kaifeng;
Jacobs, Pierre A.;
Sels, Bert F.; et al,
Green Chemistry,
2011,
13(5),
1175-1181
Synthetic Circuit 14
Reference
Method for producing ethyl lactate by reactive dividing-wall distillation column process
,
China,
,
,
Synthetic Circuit 15
1.1
Reagents:
Trimethylphosphine
Solvents:
Tetrahydrofuran
;
2 h, rt
Reference
Reduction of activated carbonyl groups by alkyl phosphines: formation of α-hydroxy esters and ketones
Zhang, Wen;
Shi, Min,
Chemical Communications (Cambridge,
2006,
(2006),
1218-1220
Synthetic Circuit 16
Reference
Method and device for reactive distillation and membrane coupling in tower
,
China,
,
,
Synthetic Circuit 17
1.1
Reagents:
Hydrogen
Catalysts:
Rhodium
,
Aluminum hydroxide oxide
Solvents:
Hexane
;
1 h, rt
Reference
Rhodium and iridium nanoparticles entrapped in aluminum oxyhydroxide nanofibers: catalysts for hydrogenations of arenes and ketones at room temperature with hydrogen balloon
Park, In Soo;
Kwon, Min Serk;
Kang, Kyung Yeon;
Lee, Jae Sung;
Park, Jaiwook,
Advanced Synthesis & Catalysis,
2007,
,
2039-2047
Synthetic Circuit 18
1.1
Reagents:
Formic acid
,
Sodium formate
Catalysts:
Rhodium(1+), (2,2′-bipyridine-κN1,κN1′)chloro[(1,2,3,4,5-η)-1,2,3,4,5-pentamethy…
;
1.5 h, pH 3.5, 40 °C
Reference
Transfer hydrogenation of a variety of ketones catalyzed by rhodium complexes in aqueous solution and their application to asymmetric reduction using chiral Schiff base ligands
Himeda, Yuichiro;
Onozawa-Komatsuzaki, Nobuko;
Sugihara, Hideki;
Arakawa, Hironori;
Kasuga, Kazuyuki,
Journal of Molecular Catalysis A: Chemical,
2003,
195(1-2),
95-100
Synthetic Circuit 19
Reference
Efficient energy-saving ethyl lactate reactive distillation production method and device
,
China,
,
,