找化学品上960化工网!
960化工网

2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖 | 97614-43-2

2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖
[(2R,3R,4S,5R)-3,5-bis(benzoyloxy)-4-fluorooxolan-2-yl]methyl benzoate
97614-43-2
C26H21FO7
464.439151525497
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖结构式
253662173
名称和标识符
MDL MFCD00083339
InChIKey JOAHVPNLVYCSAN-UXGLMHHASA-N
Inchi 1S/C26H21FO7/c27-21-22(33-24(29)18-12-6-2-7-13-18)20(16-31-23(28)17-10-4-1-5-11-17)32-26(21)34-25(30)19-14-8-3-9-15-19/h1-15,20-22,26H,16H2/t20-,21+,22-,26-/m1/s1
SMILES O([C@H]1[C@H](F)[C@@H](OC(C2C=CC=CC=2)=O)O[C@@H]1COC(C1C=CC=CC=1)=O)C(C1C=CC=CC=1)=O
别名信息
- 中文别名 -
  • 2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖
  • 克罗垃滨中间体
  • 2-脱氧-2-氟-1,3,5-三苯甲酰基-α-D-阿垃伯呋喃糖
  • 氟糖
  • 2-脱氧-2-氟-1,3,5-三苯甲酰基-alpha-D-阿拉伯呋喃糖
  • 2-脱氧-2-氟-1,3,5-三-O-苯甲酰基-α-D-阿拉伯呋喃糖
  • 1,3,5-三-O-苯甲酰基-2-脱氧-2-氟-α-D-呋喃阿拉伯糖
  • 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-alpha-D-arabinofuranose 2-脱氧-2-氟-1,3,5-三-O-苯甲酰基-α-D-阿拉伯呋喃糖
  • 2-脱氧-2-氟-1,3,5-三苯甲酰基-alpha-D-阿拉伯呋喃糖 (地西他宾)
  • 2-脱氧-2-氟-1,3,5-三苯甲酰基-alpha-D-阿拉伯呋喃糖,2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose
  • 2-脱氧-2-氟-1,3,5-三苯甲酰基-α-D- 阿拉伯呋喃糖
- 英文别名 -
  • 2-fluoro-2-deoxy-1,3,5-tri-O-benzoyl-*A-D-arabino
  • 2-deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose
  • FLuorosugar
  • 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose
  • 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-alpha-D-arabinofuranose
  • (2R,3S,4R,5R)-5-((Benzoyloxy)methyl)-3-fluorotetrahydrofuran-2,4-diyl dibenzoate
  • 1,3,5-Tri-O-benzoyl-2-deoxy-2-fluoro-alpha-D-arabinofuranose
  • 2-Fluoro-2deoxy-1,3,5-O-benzoyl-a-D-arabinofuranose
  • a-D-Arabinofuranose,2-deoxy-2-fluoro-, 1,3,5-tribenzoate
  • 1,3,5-Tri-O-Benzoyl-2-Deoxy-2-Fluoro -α-D-Arabinose
  • 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-arabinofuranose
  • α-D-Arabinofuranose, 2-deoxy-2-fluoro-, tribenzoate (9CI)
  • D
  • 2-Deoxy-2-fluoro-α-D-arabinofuranose 1,3,5-tribenzoate
  • 2′-Fluoro-2′-deoxy-1,3,5-tri-O-benzoyl-α-D-arabinofuranose
  • [(2R,3R,4S,5R)-3,5-bis(benzoyloxy)-4-fluorooxolan-2-yl]methyl benzoate
物化性质
实验特性
LogP 3.98900
PSA 88.13000
折射率 1.607
沸点 584.1°C at 760 mmHg
熔点 83.0 to 87.0 deg-C
闪点 295.7 °C
溶解度 Soluble in chloroform or dichloromethane
颜色与性状 白色结晶粉末
比旋光度 +74 ± 2° (C=1 in CH2Cl2)
密度 1.35
计算特性
精确分子量 464.12700
海关数据
海关编码 2932190090
海关数据

中国海关编码:

2932190090

概述:

2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%

申报要素:

品名, 成分含量, 用途

Summary:

2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

生产方法和用途
用途 用于合成氯法拉滨(克罗拉滨)
合成路线

合成路线:1 步

反应条件:
参考文献:
Synthesis of 2',3'-Dideoxy-2'-fluoro-3'-thioarabinothymidine and its 3'-Phosphoramidite Derivative
Elzagheid, Mohamed I.; Tedeschi, Anna Lisa; Damha, Masad J., Nucleosides, 2003, 22(5-8), 1343-1346

合成路线:1 步

反应条件:
参考文献:
Synthesis of 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose
Zhu, Lihua; Chen, Qian; Xu, Yunfeng; Fan, Juzheng, Huaxi Yaoxue Zazhi, 2005, 20(3), 207-210

合成路线:1 步

反应条件:
参考文献:
Reactivity between acetone and single-stranded DNA containing a 5'-capped 2'-fluoro-N7-methyl guanine
Mohan, Utpal; Burai, Ritwik; McNaughton, Brian R., Tetrahedron Letters, 2014, 55(22), 3358-3360

合成路线:1 步

反应条件:
参考文献:
Preparation of fluoro-sugars and other fluoro compounds
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Direct and convenient conversion of alcohols to fluorides
Yin, Jingjun; Zarkowsky, Devin S.; Thomas, David W.; Zhao, Matthew M.; Huffman, Mark A., Organic Letters, 2004, 6(9), 1465-1468

合成路线:1 步

反应条件:
参考文献:
Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver
Clark, Peter M.; Flores, Graciela; Evdokimov, Nikolai M.; McCracken, Melissa N.; Chai, Timothy; et al, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(28),

合成路线:1 步

反应条件:
参考文献:
Process for preparation of Clofarabine intermediate 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation of thiouracil nucleoside analogs for treatment of viruses and cancer
, India, , ,

合成路线:1 步

反应条件:
参考文献:
2'-Deoxy-2'-fluoro-β-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies
Wilds, Christopher J.; Damha, Masad J., Nucleic Acids Research, 2000, 28(18), 3625-3635

合成路线:1 步

反应条件:
参考文献:
Synthesis of clofarabine
Chen, Lili; Cen, Junda, Zhongguo Yiyao Gongye Zazhi, 2006, 37(8), 508-510

合成路线:1 步

反应条件:
参考文献:
Triethylamine poly(hydrogen fluorides) in the synthesis of a fluorinated nucleoside glycon
Chou, T. S.; Becke, Lisa M.; O'Toole, John C.; Carr, M. Austin; Parker, Bruce E., Tetrahedron Letters, 1996, 37(1), 17-20

合成路线:1 步

反应条件:
参考文献:
Pharmaceutical application of 2'-fluoro-4'-azido-nucleoside analog or its salt
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Improved synthesis of clofarabine
Guo, Shunmin; Deng, Sishan; Qi, Yiping; Lin, Sui, Zhongguo Xiandai Yingyong Yaoxue, 2009, 26(2), 123-125

合成路线:1 步

反应条件:
参考文献:
Preparation of 2'-fluoro-4'-substituted nucleoside analogs as antiviral agents
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Method for preparing clofarabine with high yield
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
, European Patent Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Synthesis and Structure of Duplex DNA Containing the Genotoxic Nucleobase Lesion N7-Methylguanine
Lee, Seongmin; Bowman, Brian R.; Ueno, Yoshihito; Wang, Shuyu; Verdine, Gregory L., Journal of the American Chemical Society, 2008, 130(35), 11570-11571

合成路线:1 步

反应条件:
参考文献:
Sulfur, Trifluoro[2-methoxy-N-(2-methoxyethyl)ethanaminato-κN]-,(T-4)-
Cannon, Kevin C.; Krow, Grant R., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2010, , 1-7

合成路线:1 步

反应条件:
参考文献:
Method for synthesizing nucleoside analog clofarabine
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Method for preparing 2-deoxy-2-fluoro-α-D-arabinofuranose derivatives
, China, , ,
专业数据库参考
PubChemId 253662173
参考资料
Reaxys RN 4337057
2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖推荐生产厂家
960化工网为您提供2-脱氧-2-氟-三苯甲酰基-α-D-阿垃伯呋喃糖专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:97614-43-2,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:97614-43-2
平台客服 平台客服

平台在线客服