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7-溴-2.4-二氯喹唑啉 | 959237-68-4

7-溴-2.4-二氯喹唑啉
7-bromo-2,4-dichloro-quinazoline
959237-68-4
C8H3BrCl2N2
277.932818651199
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:7-溴-2.4-二氯喹唑啉结构式
34176248
名称和标识符
MDL MFCD09954890
InChIKey RDCSNKDVAPJWGR-UHFFFAOYSA-N
Inchi 1S/C8H3BrCl2N2/c9-4-1-2-5-6(3-4)12-8(11)13-7(5)10/h1-3H
SMILES ClC1N=C2C(C=CC(=C2)Br)=C(Cl)N=1
别名信息
- 中文别名 -
  • 7-溴-2,4-二氯喹唑啉
  • 2,4-二氯-7-溴喹唑啉
  • 7-溴-2.4-二氯喹唑啉
- 英文别名 -
  • 7-Bromo-2,4-dichloroquinazoline
  • 2,4-DICHLORO-7-BROMOQUINAZOLINE
  • 7-Bromo-2,4-dichloroquizoline
  • 7-bromo-2,4-dichioro-quinazoline
  • 7-bromo-2,4-dichloro-quinazoline
  • PubChem20944
  • RDCSNKDVAPJWGR-UHFFFAOYSA-N
  • Quinazoline, 7-bromo-2,4-dichloro-
  • TRA0051196
  • PB19068
  • VZ22528
  • SY007273
  • BC004611
  • AB1000938
  • W9790
  • ST24029893
  • 7-Bromo-2,4-dichloroquinazoline (ACI)
物化性质
实验特性
LogP 3.69910
PSA 25.78000
计算特性
精确分子量 275.88600
氢键供体数量 0
氢键受体数量 2
可旋转化学键数量 0
重原子数量 13
复杂度 193
拓扑分子极性表面积 25.8
海关数据
海关编码 2933990090
海关数据

中国海关编码:

2933990090

概述:

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素:

品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

Summary:

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

合成路线

合成路线:1 步

反应条件:
参考文献:
Preparation of nucleotides as CD73 inhibitors
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists
Iwaki, Takehiko; Nakamura, Yuji; Tanaka, Taisaku; Ogawa, Yasuyuki; Iwamoto, Osamu; et al, Bioorganic & Medicinal Chemistry Letters, 2017, 27(21), 4904-4907

合成路线:1 步

反应条件:
参考文献:
Preparation of quinazoline nucleotides as CD73 inhibitors
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation of quinazoline derivatives and their use in the treatment of ocular disorders
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Characterizing the antimicrobial activity of N2,N4-disubstituted quinazoline-2,4-diamines toward multidrug-resistant Acinetobacter baumannii
Fleeman, Renee; Van Horn, Kurt S.; Barber, Megan M.; Burda, Whittney N.; Flanigan, David L.; et al, Antimicrobial Agents and Chemotherapy, 2017, 61(6),

合成路线:1 步

反应条件:
参考文献:
Triazoloquinazolines as diacylglycerol kinase modulating compounds and their preparation
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Morpholinylquinazolines as DNA-PK inhibitors and their preparation and use in the treatment of cancer
, World Intellectual Property Organization, , ,

合成路线:1 步

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参考文献:
Preparation of substituted 5-(quinazolin-2-yl)pyrimidin-2-amine derivatives useful as PI3K/mTOR inhibitors for the treatment of cancer
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation of quinazolinediamine derivatives for use as antibiotics
, United States, , ,

合成路线:1 步

反应条件:
参考文献:
Heterocyclic compounds as PRMT5 inhibitors and their preparation
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Synthesis, Inhibitory Activity and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core
Dvorakova, Marcela ; Langhansova, Lenka ; Temml, Veronika ; Pavicic, Antonio; Vanek, Tomas; et al, ACS Medicinal Chemistry Letters, 2021, 12(4), 610-616

合成路线:1 步

反应条件:
参考文献:
Preparation of functionalized quinazoline compounds as heparanase inhibitors and use thereof
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation of morpholinylheteroarylquinazolinylphenylcarbonylphenylurea derivatives and analogs for use as dual PI3K/mTOR inhibitors
, World Intellectual Property Organization, , ,

合成路线:1 步

参考文献:
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Liu, Xiangyu ; Kaindl, Jonas ; Korczynska, Magdalena; Stossel, Anne; Dengler, Daniela; et al, Nature Chemical Biology, 2020, 16(7), 749-755
专业数据库参考
PubChemId 34176248
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