94-50-8

_100%

反应条件：

1.1 Reagents: Triphenylphosphine (polymer-bound) , rel-1-[(1R,2R,4R)-Bicyclo[2.2.1]hept-5-en-2-ylmethyl] 2-[(1R,4R)-bicyclo[2.2.1]h… Catalysts: Grubbs' catalyst Solvents: Tetrahydrofuran
1.2 Solvents: Hexane

参考文献：

Impurity Annihilation: Chromatography-Free Parallel Mitsunobu Reactions

Barrett, Anthony G. M.; Roberts, Richard S.; Schroeder, Juergen, Organic Letters, 2000, 2(19), 2999-3001

合成路线：1 步

582-25-2

111-83-1

_99%

参考文献：

The synthesis of esters under microwave irradiation using dry-media conditions

Loupy, Andre; Petit, Alain; Ramdani, Mohamed; Yvanaeff, Celine; Majboub, Mustapha; et al, Canadian Journal of Chemistry, 1993, 71(1), 90-5

合成路线：1 步

19264-68-7

_100%

反应条件：

1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Tetrahydrofuran ; 24 h, 25 °C

参考文献：

Mild organic base-catalyzed primary alcohol-selective aroylation reaction using N-aroylcarbazoles for underexplored prodrugs

Morita, Yasuaki; Kang, Bubwoong; Nakashima, Rubi; Shimizu, Yuki; Sakai, Asumi; et al, ChemRxiv, 2020, 1, 1-5

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine , Pyridinium, 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-heneico… Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide ; 1 h, rt
1.2 Reagents: Water ; 5 min, rt

参考文献：

An alternative and facile purification procedure of amidation and esterification reactions using a medium fluorous Mukaiyama reagent

Matsugi, Masato; Suganuma, Misaki; Yoshida, Shoko; Hasebe, Shohei; Kunda, Yoko; et al, Tetrahedron Letters, 2008, 49(46), 6573-6574

合成路线：1 步

93-58-3

_98%

反应条件：

1.1 Catalysts: Phosphate Solvents: Toluene ; 48 h, reflux

参考文献：

Transesterification of methyl benzoate with alcohols catalyzed by natural phosphate

Bazi, Fathallaah; El Badaoui, Hanane; Sokori, Samira; Tamani, Soumia; Hamza, Mohamed; et al, Synthetic Communications, 2006, 36(11), 1585-1592

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine , 4-(Dimethylamino)pyridine , Pyridinium, 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-heneico… Solvents: Dimethylformamide ; rt; 1 h, rt
1.2 Reagents: Water ; 5 min, rt

参考文献：

A fluorous Mukaiyama coupling reagent for a concise condensation reaction: utility of medium-fluorous strategy

Sugiyama, Yuya; Kurata, Yuki; Kunda, Yoko; Miyazaki, Atsushi; Matsui, Junko; et al, Tetrahedron, 2012, 68(20), 3885-3892

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Benzenamine, N-butyl-2,4-dinitro-, 4-methylbenzenesulfonate (1:1) Solvents: Isooctane ; 24 h, reflux

参考文献：

N-Butyl-2,4-dinitro-anilinium p-toluenesulfonate as a highly active and selective esterification catalyst

Sattenapally, Narsimha; Wang, Wei; Liu, Huimin; Gao, Yong, Tetrahedron Letters, 2013, 54(48), 6665-6668

合成路线：1 步

93-58-3

_98%

反应条件：

1.1 Reagents: Diethylene glycol Catalysts: 2-Propanol, lanthanum(3+) salt Solvents: Hexane ; 1 h, rt
1.2 rt → 90 °C; 3 h, 90 °C

参考文献：

Lanthanum complexes, their uses as ester synthesis catalysts, and preparation of esters by transesterification using the complexes or lanthanum alkoxides and ligands

, Japan, , ,

合成路线：1 步

100-52-7

_98%

反应条件：

1.1 Reagents: Perchloric acid , Hydrogen peroxide Catalysts: Tin oxide (SnO2) (sulfated) ; 4 h, 323 K

参考文献：

Facile oxidation of aldehydes to esters using S·SnO2/SBA-1-H2O2

Qian, Guang; Zhao, Rui; Ji, Dong; Lu, Gaomeng; Qi, Yanxing; et al, Chemistry Letters, 2004, 33(7), 834-835

合成路线：1 步

_100%

反应条件：

参考文献：

A development of concise amidation and esterification reactions using a medium fluorous Mukaiyama reagent

Matsugi, Masato; Hayashi, Toshiya; Hasebe, Shohei; Kunda, Yoko, Meijo Daigaku Sogo Kenkyusho Sogo Gakujutsu Kenkyu Ronbunshu, 2009, 8, 123-128

合成路线：1 步

_100%

反应条件：

参考文献：

Fluorous N-alkyl-2-halopyridinium salt as condensation reagent

, Japan, , ,

合成路线：1 步

629-27-6

_99%

反应条件：

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Dimethylformamide , Tetrahydrofuran ; 20 min, rt
1.2 60 min, rt

参考文献：

Simple and convenient synthesis of esters from carboxylic acids and alkyl halides using tetrabutylammonium fluoride

Matsumoto, Kouichi; Shimazaki, Hayato; Miyamoto, Yu; Shimada, Kazuaki; Haga, Fumi; et al, Journal of Oleo Science, 2014, 63(5), 539-544

合成路线：1 步

774-65-2

_99%

反应条件：

1.1 Catalysts: Ceria ; 15 h, 180 °C

参考文献：

CeO2 as a versatile and reusable catalyst for transesterification of esters with alcohols under solvent-free conditions

Tamura, Masazumi; Hakim Siddiki, S. M. A.; Shimizu, Ken-ichi, Green Chemistry, 2013, 15(6), 1641-1646

合成路线：1 步

111-83-1

_98%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(tetradecyl)phosphonium bis(trifluoromethylsulfonyl)imide ; 10 min, 30 °C
1.2 12 h, 75 °C

参考文献：

A mild esterification process in phosphonium salt ionic liquid

McNulty, James; Cheekoori, Sreedhar; Nair, Jerald J.; Larichev, Vladimir; Capretta, Alfredo; et al, Tetrahedron Letters, 2005, 46(21), 3641-3644

合成路线：1 步

93-97-0

_99%

反应条件：

1.1 Catalysts: Bismuth triflate Solvents: Dichloromethane

参考文献：

Highly Powerful and Practical Acylation of Alcohols with Acid Anhydride Catalyzed by Bi(OTf)3

Orita, Akihiro; Tanahashi, Chiaki; Kakuda, Atsushi; Otera, Junzo, Journal of Organic Chemistry, 2001, 66(26), 8926-8934

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Triphenylphosphine , 1-Diazene-1,2-dicarboxylic acid, 1-[(4-chlorophenyl)methyl] 2-(1,1-dimethylethyl… Solvents: Dichloromethane ; 0 - 5 °C; 4 h, rt

参考文献：

Synthesis and application of a novel asymmetric azo reagent: 1-(tert-butyl)-2-(4-chlorobenzyl) azodicarboxylate (tBCAD)

Xie, Jian; Xu, Cai; Dai, Qianjin; Wang, Xiaozhong; Xu, Gang; et al, Tetrahedron, 2017, 73(35), 5321-5326

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Poly(oxy-1,2-ethanediyl), α-[2-[1-(3-sulfopropyl)-1H-imidazolium-3-yl]ethyl]-ω-[… Solvents: Toluene ; 60 min, 80 °C

参考文献：

A facile and efficient protocol for esterification and acetalization in a PEG1000-D(A)IL/toluene thermoregulated catalyst-media combined systems

Wang, Yinglei; Zhi, Huizhen; Luo, Jun, Journal of Molecular Catalysis A: Chemical, 2013, 379, 46-52

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Trichloroacetamide , Triphenylphosphine Solvents: Dichloromethane ; 1 h, reflux
1.2 Reagents: 4-Methylpyridine ; 1 h, reflux

参考文献：

Cl3CCONH2/PPh3. A versatile reagent for synthesis of esters

Chantarasriwong, Oraphin; Jang, Doo Ok; Chavasiri, Warinthorn, Synthetic Communications, 2008, 38(16), 2845-2856

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Poly(oxy-1,2-ethanediyl), α-[2-[1-(3-sulfopropyl)-1H-imidazolium-3-yl]ethyl]-ω-[… Solvents: Toluene ; 1 h, 80 °C; 80 °C → rt

参考文献：

Synthesis of α,ω-bis[(3-sulfo propyl)-1H-imidazolium-1-yl]polyethylene glycol bis(hydrogen sulfate) and determination of its properties as thermomorphic ionic liquid and its activity as esterification catalyst

Zhi, Hui-Zhen; Luo, Jun; Ma, Wei; Lu, Chun-Xu, Gaodeng Xuexiao Huaxue Xuebao, 2008, 29(4), 772-774

合成路线：1 步

111-83-1

_98%