找化学品上960化工网!
960化工网

大嘛素 | 94421-68-8

大嘛素结构式图片|94421-68-8结构式图片
大嘛素
Anandamide
94421-68-8
C22H37NO2
347.534686803818
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:大嘛素结构式
大嘛素MSDS
24890438
大嘛素价格
简介
Anandamide 是一种内源性**素。Anandamide 通过两个蛋白偶联的**素受体 (CB1 和 CB2) 调节神经元和免疫功能。Anandamide 可激活多种受体,如 PPARS、TRPV1 和 GPR18/GPR55。Anandamide 还具有抗真菌 (anti-fungal) 活性和抗炎 (anti-inflammatory) 活性。Anandamide 可用于阿尔茨海默病 (AD) 和溃疡性结肠炎的研究。
名称和标识符
MDL MFCD00153766
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
Inchi 1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
SMILES C(CC(=O)NCCO)C/C=C\C/C=C\C/C=C\C/C=C\CCCCC
别名信息
- 中文别名 -
  • (5Z,8Z,11Z,14Z)-N-(2-羟基乙基)-5,8,11,14-二十碳四烯酰胺
  • **素
  • 花生四烯酸乙醇胺
  • (5Z,8Z,11Z,14Z)-N-(2-羟基乙基)二十-5,8,11,14-四烯酰胺
  • 花生四烯酸-N-(羟乙基)酰胺
  • 大嘛素
  • 花生四烯酸 N-(羟乙基)酰胺
  • 花生四烯酰乙醇胺
- 英文别名 -
  • 5,8,11,14-Eicosatetraenamide,N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)-
  • (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
  • Anandamide
  • Anandamide (in Tocrisolve™ 100)
  • Arachidonoyl Ethanolamide Lipid Maps MS Standard
  • 5,8,11,14-Eicosatetraenoylethanolamide
  • arachidonic acid ethanolamide
  • Arachidonoyl-EA
  • arachidonylethanolamide
  • N-arachidonoyl ethanolamine
  • N-Arachidonoyl-2-hydroxyethylamide
  • N-arachidonoylethanolamide
  • AEA
  • Anandamide (20:4, n-6)
  • (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
  • Arachidonoyl ethanolamide
  • (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (ACI)
  • 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)- (ZCI)
  • (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide
  • Arachidonylethanolamide
  • N-(2-Hydroxyethyl)arachidonamide
  • N-(2-Hydroxyethyl)arachidonylamide
  • N-Arachidonoylethanolamide
  • N-Arachidonoylethanolamine
  • N-Arachidonylethanolamide
  • N-Arachidonylethanolamine
  • SMP2_000328
  • Arachidonic acid N-(hydroxyethyl)amide
  • HMS1989M15
  • N-(2-Hydroxyethyl)anachidonamide
  • N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide (all-Z)-
  • L000111
  • IDI1_034003
  • HMS3649B09
  • (all-Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
  • N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
  • Arachidonyl ethanolamide
  • NCGC00161195-04
  • Anandamide (in Tocrisolvetrade mark 100)
  • DTXSID301017453
  • 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (all-Z)-
  • E7Y
  • CHEMBL15848
  • N-arachidonoylaminoethan-2-ol
  • BRD-K42352790-001-03-8
  • Q410228
  • HMS3402M15
  • CCG-208077
  • Arachidonoylethanolamide (AEA)
  • NAE(20:4)
  • NCGC00161195-05
  • NCGC00161195-06
  • arachidonoylethanolamide
  • SR-01000946635-1
  • Anandamide (1mg/ml in Acetonitrile)
  • UR5G69TJKH
  • MFCD00153766
  • ANANDAMIDE [MI]
  • BSPBio_001533
  • SR-01000946635
  • BA166586
  • [14C]Anandamide
  • (5Z,8Z,11Z,14Z)- N-(2-Hydroxyethyl)- 5,8,11,14-eicosatetraenamide
  • UNII-UR5G69TJKH
  • 94421-68-8
  • NCGC00161195-07
  • Anandamide (20.4, n-6)
  • HMS1791M15
  • HMS1361M15
  • (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)-5,8,11,14-eicosatetraenamide
  • AnNH
  • CHEBI:2700
  • N-(2-hydroxyethyl)-5,8,11,14-Eicosatetraenamide (all-Z)
  • LMFA08040001
  • [3H]Anandamide
  • 5,8,11,14-Eicosatetraenamide, N-(2-hydroxyethyl)-, (5Z,8Z,11Z,14Z)-
  • GTPL2364
  • N-(5Z,8Z,11Z,14Z-icosatetraenoyl)-ethanolamide
  • SCHEMBL43143
  • 924894-98-4
  • AEA-D8
  • N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
  • BDBM22988
  • Anandamide(20:4, n-6)
  • AKOS015951333
  • BML2-B09
  • NCGC00161195-03
  • N-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-ethanolamine
  • Anandamide(20:4, N-6)
  • N-arachidonoylethanolamine
  • N-arachidonoyl-2-hydroxyethylamide
  • arachidonoyl ethanolamide
  • Anandamide (20.4, N-6)
物化性质
实验特性
LogP 5.63150
PSA 49.33000
折射率 1.503
沸点 522.3 ºCat 760 mmHg
蒸气压 0.0±3.1 mmHg at 25°C
闪点 14 °C
溶解度 ethanol: soluble
颜色与性状 浅黄色油状液体
溶解性 溶于乙醇
密度 0.92 g/mL at 25 °C(lit.)
计算特性
精确分子量 347.28200
氢键供体数量 2
氢键受体数量 3
可旋转化学键数量 17
同位素质量 347.282429
重原子数量 25
复杂度 408
同位素原子数量 0
确定原子立构中心数量 0
不确定原子立构中心数量 0
确定化学键立构中心数量 4
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 5.4
互变异构体数量 2
表面电荷 0
拓扑分子极性表面积 49.3
国际标准相关数据
EINECS
海关数据
海关编码 2924199090
海关数据

中国海关编码:

2924199090

概述:

2924199090. 其他无环酰胺(包括无环氨基甲酸酯)(包括其衍生物及盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素:

品名, 成分含量, 用途, 包装

Summary:

2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

合成路线

合成路线:1 步

反应条件:
参考文献:
Synthesis, In Vitro and In Vivo Evaluation, and Radiolabeling of Aryl Anandamide Analogues as Candidate Radioligands for In Vivo Imaging of Fatty Acid Amide Hydrolase in the Brain
Wyffels, Leonie; Muccioli, Giulio G.; De Bruyne, Sylvie; Moerman, Lieselotte; Sambre, Johan; et al, Journal of Medicinal Chemistry, 2009, 52(15), 4613-4622

合成路线:1 步

反应条件:
参考文献:
Solid-Phase Synthesis of Anandamide Analogues
Qi, Longwu; Meijler, Michael M.; Lee, Sang-Hyeup; Sun, Chengzao; Janda, Kim D., Organic Letters, 2004, 6(10), 1673-1675

合成路线:1 步

反应条件:
参考文献:
Composition for the treatment of immune deficiencies and methods for its preparation and use
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation and purification of arachidonylethanolamide
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Involvement of reactive oxygen species in the oleoylethanolamide effects and its pyrazonilic analogue in melanoma cells
Antiqueira-Santos, Priscila; dos Santos, Daiane S.; Hack, Carolina R. L.; Flores, Alex Fabiani C.; Montes D'Oca, Marcelo G.; et al, Medicinal Chemistry Research, 2017, 26(11), 2727-2736

合成路线:1 步

反应条件:
参考文献:
Improved Enzymatic Procedure for the Synthesis of Anandamide and N-Fatty Acylalkanolamine Analogues: A Combination Strategy to Antitumor Activity
Quintana, Paula G.; Garcia Linares, Guadalupe; Chanquia, Santiago N.; Gorojod, Roxana M.; Kotler, Monica L.; et al, European Journal of Organic Chemistry, 2016, 2016(3), 518-528

合成路线:1 步

反应条件:
参考文献:
Effects of fatty acid-ethanol amine ( FA-EA ) derivatives on lipid accumulation and inflammation
Li, Mengyu; Huang, Xiaoqing; Huang, Mengxian; Jin, Wenhui; Hong, Zhuan; et al, Lipids, 2023, 58(3), 117-127

合成路线:1 步

反应条件:
参考文献:
Preparation of anandamide and 2-arachidonyl glycerol compounds
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Synthesis of micelle-forming phosphoethanolamides of unsaturated fatty acids
Aksenov, D. V.; Babitskaya, S. V.; Kisel, M. A.; Strel'chenok, O. A., Doklady Natsional'noi Akademii Nauk Belarusi, 2001, 45(2), 63-66

合成路线:1 步

反应条件:
参考文献:
Synthesis and evaluation of fatty acid amides on the N-oleoylethanolamide-like activation of peroxisome proliferator activated receptor α
Takao, Koichi; Noguchi, Kaori; Hashimoto, Yosuke; Shirahata, Akira; Sugita, Yoshiaki, Chemical & Pharmaceutical Bulletin, 2015, 63(4), 278-285

合成路线:1 步

反应条件:
参考文献:
Enzymatic synthesis of N-acylethanolamines: direct method for the aminolysis of esters
Whitten, Kyle M.; Makriyannis, Alexandros; Vadivel, Subramanian K., Tetrahedron Letters, 2012, 53(43), 5753-5755

合成路线:1 步

反应条件:
参考文献:
Optimized synthesis and characterization of N-acylethanolamines and O-acylethanolamines, important family of lipid-signalling molecules
Ottria, Roberta; Casati, Silvana; Ciuffreda, Pierangela, Chemistry and Physics of Lipids, 2012, 165(7), 705-711

合成路线:1 步

反应条件:
参考文献:
Organic compounds with flavor-modifying properties
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Method of producing ethanolamides of polyunsaturated fatty acids
, Russian Federation, , ,

合成路线:1 步

反应条件:
参考文献:
A Convenient Protocol for the Synthesis of Fatty Acid Amides
Johansson, Silje J. R.; Johannessen, Tonje; Ellefsen, Christiane F.; Ristun, Mali S.; Antonsen, Simen; et al, Synlett, 2019, 30(2), 213-217

合成路线:1 步

反应条件:
参考文献:
Quantitative Method for the Profiling of the Endocannabinoid Metabolome by LC-Atmospheric Pressure Chemical Ionization-MS
Williams, John; Wood, JodiAnne; Pandarinathan, Lakshmipathi; Karanian, David; Bahr, Benjamin; et al, Analytical Chemistry (Washington, 2007, 79(15), 5582-5593

合成路线:1 步

反应条件:
参考文献:
Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation
Ferreri, Carla; Anagnostopoulos, Dimitris; Lykakis, Ioannis N.; Chatgilialoglu, Chryssostomos; Siafaka-Kapadai, Athanassia, Bioorganic & Medicinal Chemistry, 2008, 16(18), 8359-8365

合成路线:1 步

反应条件:
参考文献:
Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH
Wyffels, Leonie; De Bruyne, Sylvie; Blanckaert, Peter; Lambert, Didier M.; De Vos, Filip, Bioorganic & Medicinal Chemistry, 2009, 17(1), 49-56

合成路线:1 步

反应条件:
参考文献:
Preparation of amides of polyunsaturated fatty acids having aminoethanol and amino acids for use as pharmaceuticals
, United States, , ,

合成路线:1 步

反应条件:
参考文献:
Two-step method for preparing cannabinoid with high content and application thereof in the field of oil processing
, China, , ,
相关文献
专业数据库参考
PubChemId 24890438
参考资料
Reaxys RN
化合物详情(旧版)

SMILES

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO

960化工网为您提供大嘛素专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:94421-68-8,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:94421-68-8
平台客服 平台客服

平台在线客服