找化学品上960化工网!
960化工网

S-文拉法辛 | 93413-44-6

S-文拉法辛结构式图片|93413-44-6结构式图片
S-文拉法辛
S-Venlafaxine
93413-44-6
C17H27NO2
277.401785135269
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:S-文拉法辛结构式
S-文拉法辛价格
简介
(S)-Venlafaxine 是 Venlafaxine 的 S 构型化合物。Venlafaxine 是口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂。Venlafaxine 具有抗抑郁作用。
名称和标识符
InChIKey PNVNVHUZROJLTJ-MRXNPFEDSA-N
Inchi 1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3/t16-/m1/s1
SMILES [C@@H](C1C=CC(OC)=CC=1)(C1(CCCCC1)O)CN(C)C
别名信息
- 中文别名 -
  • 1-[2-(二甲基氨基)-1-(4-甲氧基苯基)乙基]环己醇
  • 文拉法辛S-异构体
  • S-文拉法辛
- 英文别名 -
  • Cyclohexanol,1-[(1S)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-
  • S-Venlafaxine
  • 1-[(1S)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol
  • (-)-Venlafaxine
  • (1R)-1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]cyclohexanol
  • (S)-VENLAFAXINE
  • 1-[(1S)-2-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL
  • BIDD:GT0838
  • R(-)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)-ethyl]cyclohexanol
  • R-venlafaxine
  • 1-[(1S)-2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (ACI)
  • Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, (S)- (ZCI)
  • (S)-Venlafaxine
物化性质
实验特性
LogP 3.03560
PSA 32.70000
熔点 102-104°C
计算特性
精确分子量 277.20400
合成路线

合成路线:1 步

反应条件:
参考文献:
Asymmetric total synthesis of (-)-venlafaxine using an organocatalyst
Chavan, Subhash P.; Garai, Sumanta; Pawar, Kailash P., Tetrahedron Letters, 2013, 54(17), 2137-2139

合成路线:1 步

反应条件:
参考文献:
Aminoalcohol-boron-BINOL complex and method for the preparation of optically active aminoalcohol derivative
, Japan, , ,

合成路线:1 步

反应条件:
参考文献:
Asymmetric synthesis of both the enantiomers of antidepressant venlafaxine and its analogues
Bhuniya, Rajib; Nanda, Samik, Tetrahedron Letters, 2012, 53(15), 1990-1992

合成路线:1 步

反应条件:
参考文献:
Preparation and formulation of O-desmethyl venlafaxine enantiomers
, World Intellectual Property Organization, , ,

合成路线:1 步

参考文献:
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity
Yardley, John P.; Husbands, G. E. Morris; Stack, Gary; Butch, Jacqueline; Bicksler, James; et al, Journal of Medicinal Chemistry, 1990, 33(10), 2899-905

合成路线:1 步

参考文献:
A process for producing enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
, World Intellectual Property Organization, , ,

合成路线:1 步

参考文献:
Preparation of venlafaxine hydrochloride crystalline polymorphs
, World Intellectual Property Organization, , ,

合成路线:1 步

参考文献:
The synthesis of (1-oxaspiro[2.5]octan-2-ylmethoxy)(tert-butyl) dimethylsilane
Liu, Dong-Wang; Tang, Lin-Jun; Huang, Fei-Fei; Wang, Li-Ping; Wang, Xiao-Ji; et al, Advanced Materials Research (Durnten-Zurich, 2014, 881, 881-883

合成路线:1 步

参考文献:
Process for resolving racemic amine by optically pure derivative of cypermethric acid
, India, , ,

合成路线:1 步

反应条件:
参考文献:
Process for preparation of chiral venlafaxine hydrochloride in crystal forms
, China, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation of (-)-venlafaxine and derivatives as neuronal monoamine reuptake inhibitors.
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Efficient resolution of venlafaxine and mechanism study via X-ray crystallography
Liu, Zhi-Jin; Liu, Han; Chen, Xuan-Wen; Lin, Min; Hu, Yu ; et al, Chirality, 2018, 30(3), 268-274

合成路线:1 步

反应条件:
参考文献:
Asymmetric synthesis of (-)-venlafaxine using organocatalyst
, World Intellectual Property Organization, , ,

合成路线:1 步

反应条件:
参考文献:
Preparation and pharmaceutical formulation of enantiomers of O-desmethyl venlafaxine
, United States, , ,

合成路线:1 步

参考文献:
Phenethylamine derivatives and intermediates
, European Patent Organization, , ,

合成路线:1 步

参考文献:
Asymmetric synthesis of (-)-venlafaxine using organocatalyst
, United States, , ,

合成路线:1 步

参考文献:
N-oxides of venlafaxine and O-desmethylvenlafaxine as prodrugs
, World Intellectual Property Organization, , ,
相关文献
S-文拉法辛推荐生产厂家
960化工网为您提供S-文拉法辛专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:93413-44-6,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:93413-44-6
平台客服 平台客服

平台在线客服