90-33-5

_100%

反应条件：

1.1 Catalysts: Aluminum chloride Solvents: Nitrobenzene ; 100 - 130 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; 0 - 10 °C

参考文献：

Synthesis and antioxidant activity of selected 4-methylcoumarins

Cavar, Sanja; Kovac, Franci; Maksimovic, Milka, Food Chemistry, 2009, 117(1), 135-142

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Hydrochloric acid ; 5 min, 100 °C

参考文献：

4-Methylcoumarins with cytotoxic activity against T24 and RT4 human bladder cancer cell lines

Vianna, D. R.; Ruschel, L.; Dietrich, F.; Figueiro, F.; Morrone, F. B.; et al, MedChemComm, 2015, 6(5), 905-911

合成路线：1 步

87-05-8

_100%

反应条件：

1.1 Solvents: Water

参考文献：

Biotransformations of 4-methylumbelliferone derivatives - fungal mediated O-dealkylations

Kumar, K. Anil; Kumar, B. S. Vijay; Laxminarayana, B.; Ananthanarayanan, S., Studies in Surface Science and Catalysis, 1998, 113, 541-546

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Ethanol, 2-(dimethylamino)-, sulfate (1:1) ; 3 h, 90 °C

参考文献：

Cholinium ionic liquids as cheap and reusable catalysts for the synthesis of coumarins via Pechmann reaction under solvent-free conditions

Zhang, Yuehua; Zhu, Anlian; Li, Qianqian; Li, Lingjun; Zhao, Yang; et al, RSC Advances, 2014, 4(44), 22946-22950

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Zirconium dioxide (borated, sulfated, phosphated) ; 6 h, 120 - 150 °C; 150 °C → rt

参考文献：

Clean and efficient synthesis of coumarins over modified metal oxides via Pechmann reaction

D'Souza, Joyce; Nagaraju, N., Indian Journal of Chemical Technology, 2008, 15(3), 244-251

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water

参考文献：

Novel thiocoumarins as inhibitors of TNF-α induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation

Kumar, Sarvesh; Singh, Brajendra K.; Kalra, Neerja; Kumar, Vineet; Kumar, Ajit; et al, Bioorganic & Medicinal Chemistry, 2005, 13(5), 1605-1613

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: (3-Mercaptopropyl)trimethoxysilane ; 1 h, 120 °C
1.2 Solvents: Ethanol ; 15 min, 120 °C

参考文献：

Competent, selective and high yield of 7-hydroxy-4-methyl coumarin over sulfonated mesoporous silica as solid acid catalysts

Khder, Abd El Rahman S.; Ahmed, Saleh A.; Khairou, Khalid S.; Altass, Hatem M., Journal of Porous Materials, 2018, 25(1), 1-13

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Iron chloride (FeCl3) ; 12 h, 70 °C

参考文献：

FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction

Prousis, Kyriakos C.; Avlonitis, Nicolaos; Heropoulos, Georgios A.; Calogeropoulou, Theodora, Ultrasonics Sonochemistry, 2014, 21(3), 937-942

合成路线：1 步

105-45-3

_99%

反应条件：

1.1 Reagents: Borane, trifluoro-, dihydrate ; 20 min, 60 °C

参考文献：

Pechmann reaction promoted by boron trifluoride dihydrate

Stoyanov, Edmont V.; Mezger, Jochen, Molecules, 2005, 10(7), 762-766

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water

参考文献：

Synthesis and antimicrobial activity of 7-[(5-(mercapto)-1,3,4-oxadiazol-2-yl)methoxy]-4-methyl-2H-chromen-2-ones

Jadhav, Rahul P.; Patil, Sachin V.; Gosavi, Shraddha S.; Mhaske, Pravin C.; Raundal, Hemant N.; et al, Indian Journal of Heterocyclic Chemistry, 2010, 20(1), 25-28

合成路线：1 步

_98%

反应条件：

1.1 60 s, heated

参考文献：

Microwave assisted, fly ash catalyzed synthesis of coumarin derivatives: green approach

Hebade, Madhav J.; Shimpi, Ravindra P.; Chavan, Omprakash S., Pharma Chemica, 2022, 14(2), 27-30

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Piperazinium, 1,4-dimethyl-1,4-bis(4-sulfobutyl)-, perchlorate (1:2) ; 19 min, 110 °C

参考文献：

Solvent-free synthesis of 4-substituted coumarins catalyzed by novel Bronsted acidic ionic liquids with perchlorate anion: a convenient and practical complementary method for pechmann condensation

Taib, Layla Ahmed; Keshavarz, Mosadegh; Parhami, Abolfath, Reaction Kinetics, 2021, 133(1), 383-403

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: Sulfuric acid

参考文献：

Chromenone and quinolinone derivatives as potent antioxidant agents

Vats, Praveen; Hadjimitova, Vera; Yoncheva, Krassimira; Kathuria, Abha; Sharma, Antara; et al, Medicinal Chemistry Research, 2014, 23(11), 4907-4914

合成路线：1 步

_100%

反应条件：

1.1 Solvents: Trifluoroacetic acid ; rt; 30 min, 100 °C; cooled; 30 min, rt

参考文献：

Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds

Zak, Jaroslav; Ron, David; Riva, Elena; Harding, Heather P.; Cross, Benedict C. S.; et al, Chemistry - A European Journal, 2012, 18(32), 9901-9910

合成路线：1 步

_100%

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid

参考文献：

PTSA catalyzed clean and efficient synthesis of 7-hydroxy-4-methylcoumarin under microwave irradiation

Mogilaiah, K.; Reddy, N. Vasudeva; Prashanthi, M.; Reddy, G. Randheer; Reddy, Ch. Srinivas, Indian Journal of Heterocyclic Chemistry, 2002, 11(4), 343-344

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Silica ; 45 min, 110 °C

参考文献：

Functionalizing HY zeolite with sulfonic acid, a micro-meso structure reusable catalyst for organic transformations

Zendehdel, Mojgan ; Tavakoli, Fatemeh, Journal of the Iranian Chemical Society, 2022, 19(4), 1095-1107

合成路线：1 步

105-45-3

_99%

反应条件：

1.1 Catalysts: Sulfuric acid ; 25 min, 100 °C

参考文献：

Easy access to coumarin derivatives using alumina sulfuric acid as an efficient and reusable catalyst under solvent-free conditions

Amoozadeh, Ali; Ahmadzadeh, Majid; Kolvari, Eskandar, Journal of Chemistry, 2013, 767825,

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Methanesulfonic acid , Silica Solvents: Octadecane ; 2 h, 160 °C

参考文献：

Silica-supported methanesulfonic acid - An efficient solid Bronsted acid catalyst for the Pechmann reaction in the presence of higher n-alkanes

Joshi, J.; Mishra, M. K.; Srinivasarao, M., Canadian Journal of Chemistry, 2011, 89(6), 663-670

合成路线：1 步

_99%