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(S)-2,2' - 双[双(3,5 - 三氟甲基苯基)膦基] -4,4',6,6' - 四甲氧基联苯 | 87694-53-9

(S)-2,2' - 双[双(3,5 - 三氟甲基苯基)膦基] -4,4',6,6' - 四甲氧基联苯
N-Boc-N-methoxy-N-methyl-L-phenylalaninamide
87694-53-9
C16H24N2O4
308.372764587402
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:(S)-2,2' - 双[双(3,5 - 三氟甲基苯基)膦基] -4,4',6,6' - 四甲氧基联苯结构式
名称和标识符
MDL MFCD00151891
InChIKey ZAHRDPIWMGLOQJ-ZDUSSCGKSA-N
Inchi 1S/C16H24N2O4/c1-16(2,3)22-15(20)17-13(14(19)18(4)21-5)11-12-9-7-6-8-10-12/h6-10,13H,11H2,1-5H3,(H,17,20)/t13-/m0/s1
SMILES [C@H](C(=O)N(C)OC)(NC(=O)OC(C)(C)C)CC1C=CC=CC=1
别名信息
- 中文别名 -
  • BOC-PHE-甲氧基甲胺
  • (S)-2,2' - 双[双(3,5 - 三氟甲基苯基)膦基] -4,4',6,6' - 四甲氧基联苯
- 英文别名 -
  • Carbamic acid,N-[(1S)-2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethylester
  • N-Boc-N-methoxy-N-methyl-L-phenylalaninamide
  • Boc-phe-n(och3)ch3
  • Carbamic acid,N-[(1S)-2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyle...
  • tert-butyl N-[(2S)-1-[methoxy(methyl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
  • [(1S)-2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
  • 1-N-Boc-1,2-cis-cyclohexyldiamine (Racemic)
  • 1-N-Boc-cis-1,2-cyclohexyldiamine
  • cis-2-(Boc-amino)cyclohexylamine
  • N-Boc-cis-1,2-cyclohexanediaMine
  • N-Boc-L-phenylalanine N'-methoxy-N'-methylamide
  • tert-butyl (1RS,2SR)-2-aminocyclohexylc
  • tert-butyl (1S)-1-benzyl-2-[methoxy(methyl)amino]-2-oxoethylcarbamate
  • tert-butyl (cis-2-aminocyclohexyl)carbamate
  • Boc-Phe-Weinreb amide
  • (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
  • Nalpha-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-L-phenylalaninamide
  • (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-ylcarbamate
  • ZAHRDPIWMGLOQJ-ZDUSSCGKSA-N
  • tert-butyl N-[(1S)-1-[methoxy(methyl)carbamoyl]-2-phenylethyl]carbamate
  • 1,1-Dimethylethyl N-[(1S)-2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]carbamate (ACI)
  • Carbamic acid, [(1S)-2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester (9CI)
  • Carbamic acid, [2-(methoxymethylamino)-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester, (S)- (ZCI)
  • N-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-L-phenylalaninamide
  • tert-Butyl (S)-N-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
  • tert-Butyl [(1S)-1-benzyl-2-[methoxy(methyl)amino]-2-oxoethyl]carbamate
物化性质
实验特性
LogP 2.53310
PSA 67.87000
计算特性
精确分子量 308.17400
氢键供体数量 1
氢键受体数量 4
可旋转化学键数量 7
重原子数量 22
复杂度 373
拓扑分子极性表面积 67.9
海关数据
海关编码 2924299090
海关数据

中国海关编码:

2924299090

概述:

2924299090. 其他环酰胺(包括环氨基甲酸酯)(包括其衍生物以及他们的盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素:

品名, 成分含量, 用途, 包装

Summary:

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

合成路线

合成路线:1 步

反应条件:
参考文献:
Probing α-Amino Aldehydes as Weakly Acidic Pronucleophiles: Direct Access to Quaternary α-Amino Aldehydes by an Enantioselective Michael Addition Catalyzed by Bronsted Bases
Garcia-Urricelqui, Ane; et al, Chemistry - A European Journal, 2021, 27(7), 2483-2492

合成路线:2 步

反应条件:
参考文献:
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine
Jorda, Radek; et al, European Journal of Medicinal Chemistry, 2017, 135, 142-158

合成路线:2 步

反应条件:
参考文献:
An efficient conversion of carboxylic acids into Weinreb amides
Katritzky, Alan R.; et al, ARKIVOC (Gainesville, 2002, (11), 39-44

合成路线:5 步

反应条件:
参考文献:
Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-α-isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active β-Hydroxy α-Amino Aldehydes and Ketones
Sawamura, Masaya; et al, Journal of Organic Chemistry, 1995, 60(6), 1727-32

合成路线:1 步

反应条件:
参考文献:
An efficient conversion of carboxylic acids into Weinreb amides
Katritzky, Alan R.; et al, ARKIVOC (Gainesville, 2002, (11), 39-44

合成路线:1 步

反应条件:
参考文献:
Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-α-isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active β-Hydroxy α-Amino Aldehydes and Ketones
Sawamura, Masaya; et al, Journal of Organic Chemistry, 1995, 60(6), 1727-32

合成路线:3 步

反应条件:
参考文献:
Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-α-isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active β-Hydroxy α-Amino Aldehydes and Ketones
Sawamura, Masaya; et al, Journal of Organic Chemistry, 1995, 60(6), 1727-32

合成路线:1 步

反应条件:
参考文献:
Assessment of the in vitro effect of antibodies induced by peptido-mimetics derived from the Plasmodium merozoite surface protein-2 in malaria caused by P. berghei and P. yoelii in BALB/c mice
Lesmes, Liliana Patricia; et al, Revista Colombiana de Ciencias Quimico-Farmaceuticas, 2010, 39(2), 188-210

合成路线:1 步

反应条件:
参考文献:
Convenient Synthesis of Alternatively Bridged Tryptophan Ketopiperazines and Their Activities against Trypanosomatid Parasites
Cockram, Peter E.; et al, ChemMedChem, 2022, 17(4),

合成路线:2 步

反应条件:
参考文献:
Convenient Synthesis of Alternatively Bridged Tryptophan Ketopiperazines and Their Activities against Trypanosomatid Parasites
Cockram, Peter E.; et al, ChemMedChem, 2022, 17(4),

合成路线:1 步

反应条件:
参考文献:
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents
Almaliti, Jehad; et al, European Journal of Medicinal Chemistry, 2019, 161, 416-432

合成路线:2 步

反应条件:
参考文献:
Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-α-isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active β-Hydroxy α-Amino Aldehydes and Ketones
Sawamura, Masaya; et al, Journal of Organic Chemistry, 1995, 60(6), 1727-32

合成路线:1 步

参考文献:
A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine
Huang, Wei; et al, Tetrahedron, 2011, 67(40), 7829-7837

合成路线:1 步

反应条件:
参考文献:
Efficient Transamidation of Primary Carboxamides by in Situ Activation with N,N-Dialkylformamide Dimethyl Acetals
Dineen, Thomas A.; et al, Journal of the American Chemical Society, 2006, 128(50), 16406-16409

合成路线:1 步

反应条件:
参考文献:
A Convenient Method for the Conversion of N-Acyloxazolidinones to Hydroxamic Acids
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反应条件:
参考文献:
Preparation of heterocyclic conformationally restricted HIV-1 protease inhibitors
, United Kingdom, , ,

合成路线:1 步

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参考文献:
Heterocyclic Cathinones as Inhibitors of Kynurenine Aminotransferase II-Design, Synthesis, and Evaluation
Maryska, Michal; et al, Pharmaceuticals, 2021, 14(12),

合成路线:1 步

反应条件:
参考文献:
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine
Jorda, Radek; et al, European Journal of Medicinal Chemistry, 2017, 135, 142-158

合成路线:4 步

反应条件:
参考文献:
Gold(I)-Catalyzed Asymmetric Aldol Reaction of N-Methoxy-N-methyl-α-isocyanoacetamide (α-Isocyano Weinreb Amide). An Efficient Synthesis of Optically Active β-Hydroxy α-Amino Aldehydes and Ketones
Sawamura, Masaya; et al, Journal of Organic Chemistry, 1995, 60(6), 1727-32

合成路线:1 步

参考文献:
Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential
Teng, Peng; et al, Chemical Communications (Cambridge, 2017, 53(87), 11948-11951
(S)-2,2' - 双[双(3,5 - 三氟甲基苯基)膦基] -4,4',6,6' - 四甲氧基联苯推荐生产厂家
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