1.1
Reagents:
Hydrochloric acid
Solvents:
Methanol
,
Water
;
20 - 30 °C; 4 h, 50 °C
1.2
Reagents:
Triethylamine
Solvents:
Water
;
50 °C; cooled; 30 min, cooled
1.3
Solvents:
Water
;
1.5 h, cooled; 30 min, 50 °C; overnight, 50 °C → 20 °C
1.4
Solvents:
Methanol
;
30 min, rt → 30 °C; 30 °C → 10 °C
1.5
Reagents:
Water
;
20 min, 10 - 15 °C; 30 min, 10 °C; 90 min, 10 - 13 °C; 20 h, 10 °C