1.1
Reagents:
Hydrochloric acid
Solvents:
1,4-Dioxane
;
rt → -10 °C; overnight, -10 °C
1.2
Solvents:
1,4-Dioxane
;
-10 °C; 1 h, -10 °C
1.3
Reagents:
Sodium hydroxide
;
neutralized, 12 °C
2.1
Reagents:
Potassium carbonate
Solvents:
Dimethylformamide
;
6 h, 65 °C