MDL | MFCD00010591 |
InChIKey | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
Inchi | 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 |
SMILES | O([H])[C@]1(C(C([H])([H])O[H])=O)C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])[C@]([H])(C([H])([H])[H])C4=C([H])C(C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[C@@]21C([H])([H])[H])O[H])=O |
LogP | 1.80360 |
PSA | 94.83000 |
Merck | 14,6111 |
折射率 | 82 ° (C=1, Dioxane) |
沸点 | 423.47°C (rough estimate) |
熔点 | 228-237 ºC (dec.) |
蒸气压 | 0.0±3.6 mmHg at 25°C |
闪点 | 571.8 °C at 760 mmHg |
溶解度 | chloroform/methanol (9:1): 50 mg/mL, clear, faintly yellow |
颜色与性状 | Powder |
溶解性 | 略微溶于乙醇、二氧六环、甲醇,微溶于丙酮、氯仿,极微溶于乙醚,不溶于水 |
敏感性 | 对光敏感 |
比旋光度 | D20 +83° (dioxane) |
密度 | 1.0868 (rough estimate) |
精确分子量 | 374.20900 |
氢键供体数量 | 3 |
氢键受体数量 | 5 |
可旋转化学键数量 | 2 |
同位素质量 | 374.209 |
重原子数量 | 27 |
复杂度 | 754 |
同位素原子数量 | 0 |
确定原子立构中心数量 | 8 |
不确定原子立构中心数量 | 0 |
确定化学键立构中心数量 | 0 |
不确定化学键立构中心数量 | 0 |
共价键单元数量 | 1 |
疏水参数计算参考值(XlogP) | 1.9 |
互变异构体数量 | 9 |
表面电荷 | 0 |
拓扑分子极性表面积 | 94.8 |
RTECS号 | TU4146000 |
WGK Germany | 2 |
安全说明 | S22-S36 |
风险术语 | R36/37/38 |
危险品标志 |
Xi
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危害声明 | H315-H319-H335 |
警示性声明 | P261-P305+P351+P338 |
储存条件 | 4°C, protect from light |
危险类别码 | 36/37/38 |
信号词 | Warning |
FLUKA BRAND F CODES | 8-10-23 |
EINECS | 201-476-4 |
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Determination of 43 prohibited glucocorticoids in cosmetic products using a simultaneous LC-MS/MS method
Nam Sook Kim,Geum Joo Yoo,Ji Hyun Lee,Hyoung-Joon Park,Sooyeul Cho,Dong Woo Shin,Younglim Kim,Sun Young Baek Anal. Methods 2017 9 2104
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Improving the accuracy of effect-directed analysis: the role of bioavailability
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Continuous-flow chemiluminescence determination of some corticosteroids
Ioanna I. Koukli,Antony C. Calokerinos Analyst 1990 115 1553
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Assembly of a series of d10 coordination polymers based on W-shaped 1,3-di(2′,4′-dicarboxyphenyl)benzene: from syntheses, structural diversity, luminescence, to photocatalytic properties
Xiutang Zhang,Liming Fan,Weiliu Fan,Bin Li,Xian Zhao CrystEngComm 2015 17 6681
7.
Structural diversity, magnetic properties, and luminescence sensing of five 3D coordination polymers derived from designed 3,5-di(2′,4′-dicarboxylphenyl)benozoic acid
Liming Fan,Yujuan Zhang,Jinfang Liang,Xiaoqing Wang,Hongxiao Lv,Jiang Wang,Li Zhao,Xiutang Zhang CrystEngComm 2018 20 4752
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Retraction: Reduction of neuronal damage and promotion of locomotor recovery after spinal cord injury by early administration of methylprednisolone: possible involvement of autophagy pathway
Yichao Jin,Shaofeng Yang,Xiaohua Zhang RSC Adv. 2022 12 26565
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Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production
Jordan E. Read,Dong Luo,Tina T. Chowdhury,Rod J. Flower,Robin N. Poston,Gleb B. Sukhorukov,David J. Gould Nanoscale 2020 12 7735
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Nanomaterial-based drug delivery systems as promising carriers for patients with COVID-19
M. Abd Elkodous,S. O. Olojede,Mahmoud Morsi,Gharieb S. El-Sayyad RSC Adv. 2021 11 26463
PubChemId | 24896564 |
Beilstein | 2340300 |
甲基氢化泼尼松物理化学性质
熔点 228-237 ºC (DEC.)
甲基氢化泼尼松产品用途
适用于风湿性关节炎、胶原病、过敏性疾病、眼科疾患、淋巴白血病、软组织炎症及溶血性贫血等
应用领域
化学品安全说明书(MSDS)
储运特性