找化学品上960化工网!
960化工网

曲安奈德 | 76-25-5

曲安奈德
Triamcinolone acetonide
76-25-5
C24H31FO6
434.4978
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:曲安奈德结构式
87558489
简介
曲安奈德(英语:Triamcinolone acetonide)是一种用来治疗各种皮肤病或减轻口疡带来不适的合成皮质类固醇。它是更有效的去炎松,大约是强的松的八倍

名称和标识符
MDL MFCD00056834
InChIKey YNDXUCZADRHECN-JNQJZLCISA-N
Inchi 1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
SMILES F[C@@]12[C@]3(C([H])=C([H])C(C([H])=C3C([H])([H])C([H])([H])[C@@]1([H])[C@]1([H])C([H])([H])[C@]3([H])[C@](C(C([H])([H])O[H])=O)([C@@]1(C([H])([H])[H])C([H])([H])[C@]2([H])O[H])OC(C([H])([H])[H])(C([H])([H])[H])O3)=O)C([H])([H])[H]
别名信息
- 中文别名 -
  • 曲安奈德
  • 醋酸曲安缩松
  • 去炎舒松
  • 确炎舒松
  • 曲安缩松
  • 去炎松-A
  • 确炎舒松-A
  • 9-氟-11b,21-二羟基-16a,17-[(1-甲基亚乙基)双(氧)]-孕甾-1,4-二烯-3,20-二酮
  • 曲安奈德原粉
  • Triamcinolone Acetonide 曲安奈德
  • 醋酸曲安奈德
  • 醋酸曲安缩松,CP2005, USP, BP, EP
  • 曲安奈德 USP
  • 曲安奈德 USP标准品
  • 曲安奈德 标准品
  • 曲安奈德标准品(JP)
  • 曲安奈德原药
  • 曲安奈德中间体
  • 曲安萘德
  • 9-氟-11β,21-二羟基-16α,17-[(1-甲基亚乙基)双(氧)]-孕甾-1,4-二烯-3,20-二酮
  • 己曲安西龙杂质A(EP) 标准品
  • 四氢噻唑
  • 9α-氟-11β,16α,17α,21-四羟基-1,4-孕甾二烯-3,20-二酮-16,17-丙酮化合物
  • 9α-氟-16α-羟基波尼松龙 16α,17α-丙酮化合物
  • 曲安奈德(分析标准品)
- 英文别名 -
  • Triamcinolone acetonide
  • Triamcinolone Acetonide BP98
  • 9-alpha-fluoro-11-beta,21-dihydroxy-16-alpha,17-alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
  • 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
  • 9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
  • Triamcinolon Acetonide
  • Triamcinolone (acetonide)
  • Triamcinolone Aceton
  • TRIAMCINOLONE ACETONIDE, USP
  • Thiazolidine
  • 9α-Fluoro-11β,21-dihydroxy-16α,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
  • Triamcinoloneacetonide
  • Azmacort
  • Aristoderm
  • Aristogel
  • Solodelf
  • Kenalone
  • Tricinolon
  • Triaceton
  • Tramacin
  • Kenalog
  • Rineton
  • Flutone
  • Triam-Injekt
  • Adcortyl A
  • Omcilon A
  • Nasacort AQ
  • Volon A
  • Coupe-A
  • Aristocort acetonide
  • Kenalog 40
  • Triamcinolone 16,17-acetonide
  • Triacort
  • Oracort
  • Triderm
  • Zilretta
  • Oralone
  • Triatex
  • Acetospan
  • Flutex
  • Volon A 40
  • Triamcincolone acetonide
  • Kenalog-H
  • Nasacort HFA
  • Triamonide 40
  • Kenalog in Orabase
  • Vetalog (Veterinary)
  • Nas
  • F446C597KA
  • 9alpha-Fluoro-16-hydroxyprednisolone acetonide
  • CLS-1001
  • Nystadermal
  • Triamcinolone acetonide 100 microg/mL in Methanol
  • Opera_ID_232
  • TRIAMCINOLONE ACETONIDE (SEE ALSO TRIAMCINOLONE (124-94-7))
  • (11beta,16alpha)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • Triamcinolone Acetonide, Pharmaceutical Secondary Standard
  • Certified Reference Material
  • TRIAMCINOLONE ACETONIDE [MI]
  • CAS-76-25-5
  • TRIAMCINOLONE ACETONIDE (USP-RS)
  • HMS2232F22
  • SCHEMBL4689
  • UNII-F446C597KA
  • Tricort-40
  • Ledercort cream
  • Triamcinolone acetonide, analytical standard
  • 9-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
  • Triamcinolone Acetonide in Absorbase
  • NCGC00023193-06
  • TAC-3
  • BDBM50248362
  • Kenacort-A
  • NSC-21916
  • MLS000028538
  • TRIAMCINOLONE ACETONIDE COMPONENT OF MYCOLOG
  • S1628
  • MYTREX F COMPONENT TRIAMCINOLONE ACETONIDE
  • Volonimat
  • XIPERE
  • Triamcinolone acetonide (JP17/USP)
  • NC00591
  • TRIAMCINOLONE ACETONIDE (USP MONOGRAPH)
  • SMR000058335
  • 9-alpha-Fluoro-16-alpha-17-alpha-isopropyledenedioxyprednisolone
  • LS-1692
  • DTXSID6021371
  • 9.alpha.-Fluoro-11.beta.,4-pregnadiene,3,20-dione
  • Triamcinolone acetonide [JAN]
  • 9-alpha-Fluoro-16-alpha-17-alpha-isopropylidenedioxy-delta-1-hydrocortisone
  • C08183
  • Kenacort A
  • AB00383012-11
  • Trianex
  • KS-5330
  • Aureocort
  • CHEBI:71418
  • Pregna-1,20-dione, 9-fluoro-11.beta.,21-dihydroxy-16.alpha.,17-(isopropylidenedioxy)-
  • 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11beta,16alpha)-
  • TRIAMCINOLONE ACETONIDE [EP MONOGRAPH]
  • A856341
  • Pregna-1,20-dione, 9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11.beta.,16.alpha.)-
  • NSC 21916
  • TRIAMCINOLONE ACETONIDE (MART.)
  • NCGC00259344-01
  • Triacet
  • MFCD00056834
  • 9alpha-Fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene,3,20-dione
  • Triamcinolone-Acetonide
  • Trymex
  • DTXCID201371
  • MYCOLOG COMPONENT TRIAMCINOLONE ACETONIDE
  • Acetonide, Triamcinolone
  • Cinonide
  • Aristocort A
  • aristicort
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho(2',1':4,5)indeno(1,2-d)(1,3)dioxol-2-one
  • Pregna-1,20-dione, 9-fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Q2211240
  • TRIAMCINOLONE ACETONIDE
  • 76-25-5
  • Azmacort
  • Aristogel
  • Nasacort
  • CHEMBL1504
  • ReadySharp Triamcinolone
  • MLS001148264
  • BRD-K53790871-001-08-6
  • Trivaris
  • CCG-269068
  • TRIAMCINOLONE ACETONIDE [WHO-DD]
  • 5-19-06-00568 (Beilstein Handbook Reference)
  • 9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone 16.alpha.,17.alpha.-acetonide
  • (4aS,4bR,5S,6aS,6bR,9aR)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
  • 9alpha-Fluoro-16alpha-17alpha-isopropyledenedioxyprednisolone
  • 9alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
  • NSC21916
  • GTPL2867
  • 9.alpha.-Fluoro-16-hydroxyprednisolone acetonide
  • Vetalog
  • 9-alpha-Fluoro-16-alpha-hydroxyprednisolone 16-alpha,17-alpha-acetonide
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • 9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide
  • AB00383012_12
  • Kenalog-40
  • Gppe Ear Dps Cap
  • fx-006
  • Silderm
  • FLUOCINOLONE ACETONIDE IMPURITY H
  • TRIAMCINOLONE ACETONIDE
  • Respicort
  • Tox21_201795
  • Triamsinolone acetonide
  • Asmacort (common misspelling of Azmacort)
  • TRIAMCINOLONE ACETONIDE [USP MONOGRAPH]
  • TRIAMCINOLONE ACETONIDE [VANDF]
  • KENALOG-80
  • Tri-Adcortyl
  • Triamcinolone acetonide for system suitability, European Pharmacopoeia (EP) Reference Standard
  • Nasacort
  • Tox21_110885
  • Tox21_303014
  • AKOS015894871
  • 9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione
  • Gppe Ear Oint
  • 9.alpha.-Fluoro-16.alpha.-17.alpha.-isopropyledenedioxyprednisolone
  • HY-B0636
  • MYKACET COMPONENT TRIAMCINOLONE ACETONIDE
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • MYTREX A COMPONENT TRIAMCINOLONE ACETONIDE
  • AC-1239
  • Extracort
  • Triamcinolone acetonide, European Pharmacopoeia (EP) Reference Standard
  • Pregna-1,20-dione, 9-fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-,cyclic 16,17-acetal with acetone
  • TRIAMCINOLONE ACETONIDE COMPONENT OF MYKACET
  • MLS002638825
  • Triesence
  • NCGC00023193-05
  • NCGC00023193-04
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11.beta.,16.alpha.)-
  • TRIAMCINOLONE ACETONIDE [ORANGE BOOK]
  • 9-alpha-fluor-11-beta,21-dihydroxy-16-alpha-17-alpha-isopropylidendioxypregna-1,4-dien-3,20-dion
  • TRIAMCINOLONE ACETONIDE [GREEN BOOK]
  • 9alpha-Fluoro-16alpha-hydroxyprednisolone 16alpha,17alpha-acetonide
  • 9alpha-Fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione
  • HMS3259A20
  • Triamcinolone acetonide [USP:INN:BAN:JAN]
  • TRIAMCINOLONE HEXACETONIDE IMPURITY A [EP IMPURITY]
  • BRN 0060069
  • 9-alpha-fluoro-16-alpha,17-isopropylidenedioxyprednisolone
  • FX006
  • Tri-Nasal
  • Asmacort [Common Misspelling of Azmacort]
  • Adcortyl In Orabase
  • 9.alpha.-Fluoro-16.alpha.-17.alpha.-isopropylidenedioxy-.delta.-1-hydrocortisone
  • 76-25-5
  • CLS1001
  • TRIAMCINOLONE ACETONIDE (EP MONOGRAPH)
  • Kenalog-10
  • TRIAMCINOLONE ACETONIDE [USP-RS]
  • TRIAMCINOLONE ACETONIDE COMPONENT OF MYTREX A
  • CCRIS 5231
  • AllerNaze
  • WLN: T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1 FV1Q H1 H1
  • MLS002207192
  • (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • 9-alpha-Fluoro-16-hydroxyprednisolone acetonide
  • 9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha,17-alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
  • Pevaryl T.C.
  • EINECS 200-948-7
  • YNDXUCZADRHECN-JNQJZLCISA-N
  • Panolog Ointment (Veterinary)
  • Audicort
  • DIMETHYL2-(3-NITRO-2-PYRIDYL)MALONATE
  • Kenalone, Solodelf
  • 9alpha-fluoro-16alpha-17alpha-isopropylidenedioxy-Delta-1-hydrocortisone
  • Triamcinolone acetonide, United States Pharmacopeia (USP) Reference Standard
  • Remiderm
  • Ftorocort
  • Tox21_110885_1
  • NCGC00256560-01
  • D00983
  • (11-beta,16-alpha)-9-Fluoro-11,21-dihydroxy-16,17-[1-methylethylidenebis(oxy)]pregna-1,4-diene-3,20-dione
  • 1TA
  • Q-201855
  • Nasacort Allergy 24 Hour
  • Tri-Nasal Spray
  • CS-O-02472
  • TRIAMCINOLONE ACETONIDE [MART.]
  • Remotic
  • TRIAMCINOLONE ACETONIDE COMPONENT OF MYTREX F
  • PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-
  • Triamcinolone Acetonide Acetate
  • HY-B0636R
  • Pediaderm Ta
  • Equate Nasal Allergy
  • Good Neighbor Pharmacy 24 Hour Nasal Allergy
  • Triamcinolone acetonide (Standard)
  • TRITOCIN
  • Vetalog Parenteral
  • Triamcinolone Acetonide Cream .1%
  • 24 Hour Nasal Allergy
  • Triamcinolone Acetonide Nasal
  • Trivix Lite
  • CS-0695000
  • Genesis Topical Spray
  • Pro-C-Dure 6 Kit
  • Triam
  • Health Mart 24 hour nasal allergy
  • Nasacort Allergy 24hr
  • Triamcinolone Acetonide Ointment
  • Up and Up Nasal Allergy
  • Protherix
  • Triamcinolone Acetonide Ointment USP, 0.05%
  • Sila III
  • Equaline nasal allergy
  • Trianex 0.05%
  • Nasal Allergy 24 Hour
  • Good Sense Nasal Allergy
  • Triloan II SUIK
  • Nasal Allergy
  • Basic Care Nasal Allergy
  • kirkland signature aller cort
  • Triloan SUIK
  • DG Health Nasal Allergy
  • ORAMEDY
  • Medalone Cream
  • NS00009342
  • 0.015% triamcinolone acetonide
  • foster and thrive 24 hour nasal allergy
  • Kenalog (TN)
  • Signature Care Nasal Allergy
  • Nasacort (TN)
  • Azmacort (TN)
  • Triasil
  • Pro-C-Dure 5 Kit
  • Triamcinolone acetonide (USP:INN:BAN:JAN)
  • Leader Nasal Allergy
  • Triamcinolone Acetonide Suspension
  • Topcare Nasal Allergy
  • triamcinolone acetonide cream
物化性质
实验特性
LogP 2.41880
PSA 93.06000
Merck 9596
折射率 1.5980 (estimate)
水溶性 Soluble in DMSO or ethanol. Slightly soluble in water.
沸点 576.9°C at 760 mmHg
熔点 294°C(lit.)
闪点 302.7±30.1 °C
溶解度 生物体外In Vitro:DMSO溶解度50 mg/mL(115.07 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble)
颜色与性状 Powder
稳定性 Combustible. Incompatible with strong oxidizing agents.
溶解性 不确定
比旋光度 +109° (c=0.75, CHCl3)
密度 1.1517 (estimate)
计算特性
精确分子量 434.21000
氢键供体数量 2
氢键受体数量 7
可旋转化学键数量 2
同位素质量 434.210467
重原子数量 31
复杂度 925
同位素原子数量 0
确定原子立构中心数量 8
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 2.5
互变异构体数量 9
表面电荷 0
拓扑分子极性表面积 93.1
国际标准相关数据
EINECS 200-948-7
海关数据
海关编码 2937229000
海关数据

中国海关编码:

2937229000
生产方法和用途
用途 肾上腺皮质激素类药,作用于糖代谢,能减轻抗体组织对损害性刺激所产生的病理反应,用于活动性风湿病及类风湿关节炎等。
相关文献
专业数据库参考
PubChemId 87558489
参考资料
Reaxys RN 60069
Beilstein 19(5)6,568
化合物详情(旧版)

曲安奈德的物理化学性质

外观性状:醋酸酯为白色或类白色结晶性粉末,无臭,味苦。
溶解性:极微溶于水,微溶于乙醇,溶于氯仿,略溶于丙酮。

熔点:274-278°C (dec.) 
Merck:9596 
稳定性:Combustible. Incompatible with strong oxidizing agents. 

概述

曲安奈德是目前在我国皮肤科临床应用较广泛的一种长效糖皮质激素类药物,又称曲安舒松、去炎舒松、康宁克通、康纳乐霜、康纳克-A,属肾上腺皮质激素类药,为曲安西龙(去炎松)的衍生物,作用与曲安西龙相似,具有抗炎、抗过敏、抗瘙痒和收缩毛细血管的作用,其水钠潴留作用微弱,而抗炎、抗过敏作用均比氢化可的松(10~30倍)、泼尼松强而持久,气雾吸入治疗支气管哮喘,作用强且持久。对局部作用疗效较曲安西龙好。口服易吸收。口服5mg,生物利用度约23%,1小时血药浓度达峰值105ng/ml,半衰期为2小时;肌注吸收缓慢,数小时内起效,1~2日达最大效应,作用可维持2~3周;皮内、关节腔内局部注射本药吸收缓慢,作用持久,一般注射一次疗效可维持1~2周以上。本药与血浆白蛋白结合少,吸收后在肝、肾和组织中代谢为无活性代谢产物,经肾排出。局部注射时亦可呈现持久作用,软膏外用也能产生较好疗效。临床上曲安奈德主要用于治疗各种皮肤病如过敏性皮炎、接触性皮炎、脂溢性皮炎、神经性皮炎、湿疹、银屑病、牛皮癣、扁平苔癣等皮肤病及皮肤瘙痒症,以及支气管哮喘、风湿性关节炎、急性扭伤、慢性腰腿痛、肩周炎、腱鞘炎、眼科炎症、口腔黏膜充血、糜烂面、溃疡、肉芽肿性唇炎、口腔黏膜慢性感染性疾病,也可用于瘢痕疙瘩、囊肿性痤疮、盘状红斑狼疮、斑秃等小面积损害的局部注射。醋酸曲安奈德鼻喷雾剂可用于预防和治疗常年性、季节性过敏性鼻炎和血管舒缩性鼻炎。关节内注射,可消除炎症,并使疼痛、肿胀或僵硬感觉获得缓解。

曲安奈德的产品用途

为肾上腺皮质激素类药,用于神经性皮炎、湿疹、牛皮癣、关节痛、支气管哮喘等病症

曲安奈德的安全特性

类别:有毒物品 
毒性分级:高毒 
急性毒性:皮下-大鼠 LD50: 13.1 毫克/公斤; 腹腔-小鼠 LD50: 105 毫克/公斤 
可燃性危险特性:可燃;燃烧产生有毒氟化物烟雾 
灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水 

 曲安奈德的储运特性

库房通风低温干燥;与食品原料分开存放。

扩展阅读
曲安奈德新霉素贴膏 曲安奈德新霉素贴膏,适应症为用于局限性神经性皮炎,慢性湿疹。也可用于小面积的银屑病。
产品用途
为肾上腺皮质激素类药,用于神经性皮炎、湿疹、牛皮癣、关节痛、支气管哮喘等病症
曲安奈德推荐生产厂家
960化工网为您提供曲安奈德专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:76-25-5,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:76-25-5
平台客服
平台客服

平台在线客服