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利血平 | 50-55-5

利血平
Reserpine
50-55-5
C33H40N2O9
608.6787
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:利血平结构式
利血平MSDS
5770
利血平价格
简介
         利血平(Reserpine)白色或浅黄褐色结晶性粉末,一种吲哚型生物碱。存在于萝芙木属多种植物中,在催吐萝芙木中含量最高可达1%。该品广泛应用于轻度和中度高血压的治疗。常与噻嗪类药合用以增加疗效。该药能长期服用,耐受用良好。
名称和标识符
MDL MFCD00005091
InChIKey QEVHRUUCFGRFIF-MDEJGZGSSA-N
Inchi 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
SMILES O(C([H])([H])[H])[C@@]1([H])[C@@]([H])(C([H])([H])[C@]2([H])C([H])([H])N3C([H])([H])C([H])([H])C4C5C([H])=C([H])C(=C([H])C=5N([H])C=4[C@@]3([H])C([H])([H])[C@]2([H])[C@]1([H])C(=O)OC([H])([H])[H])OC([H])([H])[H])OC(C1C([H])=C(C(=C(C=1[H])OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H])=O
BRN 102014
别名信息
- 中文别名 -
  • 利血平
  • 血安平
  • 蛇根碱
  • 白杨素
  • 大青叶提取物
  • 拉米夫定
  • 利血平 EP标准品
  • 利血平 USP标准品
  • 利血平 标准品
  • 利血平(标准品)
  • 利血平, 来源于萝芙木属植物
  • 利血平 植物提取物,标准品,对照品
  • 利血平,分析标准品
  • 利血平标准品(JP)
  • 萝芙木提取物
  • 印度穆库尔没药(没药甾酮)
  • 利舍平
  • 蛇根草素
  • 寿比安
  • 利血平,利舍平,蛇根碱,血安平
- 英文别名 -
  • Reserpine
  • reserpine crystalline
  • 3,4,5-Trimethoxybenzoyl methyl reserpate
  • Reserpine base
  • Resperine
  • ​Reserpine
  • methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
  • RESERPINE(P) PrintBack
  • [3H]-Reserpine
  • Apoplon
  • Crystoserpine
  • Eskaserp
  • Hiserpia
  • methyl reserpate 3,4,5-trimethoxybenzoic acid ester
  • Raunervil
  • Raupasil
  • Raused
  • Rausedil
  • Reserpoid
  • Rivasin
  • Sandril
  • Serpalan
  • Serpanray
  • Serpasil
  • Serpivite
  • (3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
  • 3b,20a-Yohimban-16b-carboxylic acid, 18b-hydroxy-11,17a-dimethoxy- methyl ester 3,4,5-trimethoxybenzoate (ester)(8CI)
  • 3b,20a-Yohimban-16b-carboxylic acid,18b-hydroxy-11,17a-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate(6CI)
  • Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.
  • (-)-Reserpine
  • 11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acidmethyl ester
  • Anquil
  • Banasil
  • Bioserpine
  • Carpacil
  • Deserpine
  • ENT 50146
  • Elserpine
  • Eserpine
  • Hiposerpil
  • Kitine
  • Lemiserp
  • Loweserp
  • Mayserpine
  • Methylreserpate 3,4,5-trimethoxybenzoate (ester)
  • NSC 237659
  • NSC 59272
  • Quiescin
  • Rau-sed
  • Raucap
  • Raulen
  • Raurine
  • Rausedyl
  • Rausingle
  • Rauwasedin
  • Resercaps
  • Resercen
  • Reserlor
  • Reserpamed
  • Reserpex
  • Reserpic acid methyl ester 3,4,5-trimethoxybenzoate (ester)
  • Reserpil
  • Resine
  • Respital
  • Restran
  • Riserpa
  • Roxinoid
  • Sedaraupin
  • Sedserp
  • Serfin
  • Serolfia
  • Serp-AFD
  • Serpaloid
  • Serpasil Serpasol
  • Serpasil premix
  • Serpasol
  • Serpate
  • Serpen
  • Serpentina
  • Serpicon
  • Serpiloid
  • Serpine
  • Serpine (pharmaceutical)
  • Serpipur
  • Sertabs
  • Sertina
  • T-Serp
  • Temposerpine
  • Triserpin
  • Vio-Serpine
  • Alserin
  • Hypersil
  • Enipresser
  • Helfoserpin
  • Eskaserpine
  • Rauserpine
  • Purserpine
  • Mephaserpin
  • Reserpanca
  • Maviserpin
  • Austrapine
  • Ascoserpina
  • Reserpal
  • Reserjen
  • Rautrin
  • Rauserpol
  • Raudixoid
  • Neoserp
  • Idsoserp
  • Hypersine
  • Escaspere
  • Apsical
  • A
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-(3,4,5-trimethoxybenzoyl)oxy-, methyl ester, (3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-
  • Reserpine, certified reference material, TraceCERT(R)
  • SMR000059122
  • NCGC00091250-03
  • Brinderdin
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18- [(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxyl ic acid methyl ester
  • Reserpine, Pharmaceutical Secondary Standard
  • Certified Reference Material
  • IDI1_000012
  • Orthoserpina
  • Resperin
  • METHYL 18.BETA.-HYDROXY-11,17.ALPHA.-DIMETHOXY-3.BETA.,20.ALPHA.-YOHIMBAN-16.BETA.-CARBOXYLATE 3,4,5-TRIMETHOXYBENZOATE (ESTER).
  • Hydrosine 25
  • Naquival
  • Reserpene
  • RESERPINE [ORANGE BOOK]
  • Metatensin #2
  • RESERPINE (MART.)
  • Yohimban-16-carboxylic acid,11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester,(3b,16b,17a,18b,20a)-
  • Tri-Hydroserpine
  • Spectrum5_001415
  • Diupres 500
  • (1S,2R,3R,4aS,13bR,14aS)-methyl2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
  • Raugal
  • Rezerpin
  • Unilord
  • HMS2097P11
  • Benazyl
  • NCI60_004446
  • RESERPINE COMPONENT OF CAM-AP-ES
  • Tepserpine
  • Broserpine
  • HYDRO-SERP '25'
  • Methyl reserpate 3,5-trimethyloxybenzoic acid
  • HYDROMOX R COMPONENT RESERPINE
  • RESERPINE COMPONENT OF SERPASIL-ESIDRIX
  • SW196458-3
  • UNM000011053801
  • Reserpine Standard for LC-MS, analytical standard, for LC-MS
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
  • Raupoid
  • Methyl 18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate 3,4,5-trimethoxybenzoate (ester)
  • methyl o-(3,4,5-trimethoxybenzoyl)reserpate
  • 4-25-00-01319 (Beilstein Handbook Reference)
  • Rauserpin
  • HMS1570P11
  • Serpivate
  • CHEBI:28487
  • RESERPINE COMPONENT OF NAQUIVAL
  • RESERPINE AND HYDROCHLOROTHIAZIDE-50
  • AMY591
  • RESERPINE [USP MONOGRAPH]
  • Raumorine
  • KBio2_003117
  • Rawilid
  • Transerpin
  • Hypercal B
  • 3beta,20alpha-yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester)
  • RESERPINE COMPONENT OF SER-AP-ES
  • Rausan
  • Reserpinum
  • Reserutin
  • Butiserpazide-25
  • Reserpur
  • RCRA waste no. U200
  • SBI-0050061.P004
  • Methylreserpate 3,4,5-trimethoxybenzoic acid
  • METHYL (3.BETA.,16.BETA.,17.ALPHA.,18.BETA.,20.ALPHA.)-11,17-DIMETHOXY-18-((3,4,5-TRIMETHOXYBENZOYL)OXY)YOHIMBAN-16-CARBOXYLATE
  • Sertens
  • Supergan
  • SCHEMBL2589
  • SER-AP-ES COMPONENT RESERPINE
  • Rolserp
  • Metatensin #4
  • Diurese-R
  • 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy- methyl ester 3,4,5-trimethoxybenzoate (ester)
  • RESERPINE COMPONENT OF HYDROPRES
  • yohimban-16-carboxylic acid derivative of benz[g]indolo[2,3-a]quinolizine
  • Alkaserp
  • Serpilum
  • Seominal
  • Reserpine, crystallized, >=99.0% (HPLC)
  • RESERPINE COMPONENT OF HYDRAP-ES
  • Pharmakon1600-01500526
  • Carrserp
  • HSDB 213
  • RENESE-R COMPONENT RESERPINE
  • Reserpin
  • Salupres
  • SERPASIL-APRESOLINE COMPONENT RESERPINE
  • Banisil
  • Lopac0_000073
  • METHYL 18beta-HYDROXY-11,17alpha-DIMETHOXY-3beta,20alpha-YOHIMBAN-16beta-CARBOXYLATE 3,4,5-TRIMETHOXYBENZOATE (ESTER).
  • DIUTENSEN-R COMPONENT RESERPINE
  • RESERPINE (USP-RS)
  • HYDRAP-ES COMPONENT RESERPINE
  • Reserfia
  • H 520
  • methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4(9),5,7-tetraene-19-carboxylate
  • component of Butiserpazide
  • (3?,16?,17?,18?,20?)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
  • Apoplon (TN)
  • gammaserpine
  • Trichlortensin
  • HMS3714P11
  • LP00073
  • UNII-8B1QWR724A
  • Benz[g]indolo[2, 1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-3-hydroxy-2,11-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate
  • Methylreserpate 3,4,5-Trimethoxybenzoic acid ester
  • RESERPINE COMPONENT OF RENESE-R
  • Hexaplin
  • DB00206
  • Recipin
  • C33H40N2O9
  • C02AA02
  • V Serp
  • Resedrex
  • Terbolan
  • 8B1QWR724A
  • BDBM50017712
  • Marnitension simple
  • CHEMBL772
  • Cardioserpin
  • METATENSIN COMPONENT RESERPINE
  • Reserpine [USP:INN:BAN:JAN]
  • A913268
  • rese rpamed
  • reserpin-
  • methyl o-(3,4,5-trimethoxybenzo yl)reserpate
  • Hydroserpine Plus
  • Hydroserpalan
  • Resiatric
  • RESERPINE [MART.]
  • RESERPINE COMPONENT OF UNIPRES
  • Diupres 250
  • Serpedin
  • Neoserfin
  • NCI-C50157
  • Z1251172867
  • :reserpine
  • Hiposepil
  • QEVHRUUCFGRFIF-MDEJGZGSSA-N
  • RESERPINE (EP MONOGRAPH)
  • H.R.-50
  • HMS3260O07
  • Hypertane forte
  • DTXCID201237
  • Spectrum3_000894
  • ENT-50146
  • UNIPRES COMPONENT RESERPINE
  • MLS006011754
  • NINDS_000012
  • CCRIS 550
  • component of Naquival
  • NSC-59272
  • 3-.beta., 18-.beta.-hydroxy-11,17-.alpha.-dimethoxy-,methyl ester, 3,4,5-trimethoxybenzoate (ester)
  • NSC-237659
  • Methyl reserpate 3,4,5-trimethoxybenzoate (ester)
  • Reserpidefe
  • HYDRO-RESERP COMPONENT RESERPINE
  • Renese R
  • Ascoserp
  • Trimethoxybenzoyl methyl reserpate
  • NCGC00091250-10
  • HMS2234E24
  • se rpate
  • KS-5106
  • Serpazil
  • Hydroserpine #1
  • MLS002154046
  • Tox21_111107
  • Sederaupin
  • Key-serpine
  • 50-55-5 (free)
  • Spectrum4_000989
  • Reserbal
  • Raunorine
  • RESERPINE COMPONENT OF HYDROSERPINE PLUS (R-H-H)
  • BBL028800
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-
  • HYDROCHLOROTHIAZIDE W/ RESERPINE
  • RESERPINE AND HYDROCHLOROTHIAZIDE
  • Q-100566
  • Resedril
  • Reserpka
  • RESERPINE COMPONENT OF HYDROMOX R
  • RESERPINE (IARC)
  • HYDRO-RESERP
  • Hydropine
  • NCGC00259944-01
  • Serpentin
  • HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE-RESERPINE COMPONENT RESERPINE
  • KBioGR_001397
  • REGROTON COMPONENT RESERPINE
  • SALUTENSIN COMPONENT RESERPINE
  • Serpena
  • Rauwiloid
  • Serathide
  • methyl dimethoxy-(3,4,5-trimethoxybenzoyl)oxy-[?]carboxylate
  • AC-34405
  • Reserp
  • C06539
  • Tensanyl
  • ACon1_000086
  • Hydropres 50
  • l -Carpserp
  • WLN: T F6 D5 C666 EM ON&&TTTJ HO1 SOVR CO1 DO1 EO1& TO1 UVO1
  • RESERPINE COMPONENT OF H.R.-50
  • RESERPINE COMPONENT OF DRALSERP
  • Rcra waste number U200
  • NSC59272
  • Rivased
  • HMS3884I21
  • 79 more names available
  • RESERPINUM [HPUS]
  • RESERPINE COMPONENT OF REGROTON
  • HMS1920P04
  • CS-1913
  • Salazide-Demi
  • Tensional
  • Veriloid
  • Hydropres 25
  • RESERPINE COMPONENT OF SER-A-GEN
  • Rausedan
  • V-Serp
  • NCGC00091250-12
  • Residin
  • KBio1_000012
  • RESERPINE [INN]
  • DTXSID7021237
  • NSC237659
  • Chloroserp-250
  • RESERPINE COMPONENT OF METATENSIN
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)yohimban-16-carboxylic acid methyl ester
  • BRD-K95921201-001-07-0
  • SER-A-GEN COMPONENT RESERPINE
  • reserpine
  • Hydro-Reserpine-25
  • HMS2092G05
  • Raunova
  • Prestwick_147
  • CAM-AP-ES COMPONENT RESERPINE
  • HYDRO-SERP '50'
  • component of Regroton
  • Interpina
  • Tempo-Reserpina
  • NCGC00091250-06
  • RESERPINE COMPONENT OF SERPASIL-APRESOLINE
  • Reser-ar
  • 3.beta., 18.beta.-hydroxy-11,17.alpha.-dimethoxy- methyl ester 3,4,5-trimethoxybenzoate (ester)
  • BSPBio_000949
  • methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-{[(3,4,5-trimethoxyphenyl)carbonyl]oxy}yohimban-16-carboxylate
  • Rauwita
  • Serpasil-Esidrix #2
  • DRALSERP COMPONENT RESERPINE
  • NCGC00091250-01
  • Reserpine,(S)
  • Serfolia
  • Diupres
  • Prestwick1_000875
  • 3-beta,20-alpha-yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester,3,4,5-trimethoxybenzoate (ester)
  • GTPL4823
  • Serpogen
  • 3,5-Trimethoxybenzoyl methyl reserpate
  • R 0875
  • Rauwipur
  • Reserpine (JP17/USP/INN)
  • Ebserpine
  • NCGC00091250-04
  • Pressimedin
  • Gilucard
  • NCGC00091250-05
  • Q407841
  • RESERPINE [MI]
  • Solfo serpine
  • Residine
  • NCGC00091250-25
  • Tox21_500073
  • Eberpine
  • Reserpina [INN-Spanish]
  • AI3-50146
  • methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-[(3,4,5-trimethoxyphenyl)carbonyloxy]-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate
  • Prestwick0_000875
  • RKL10049
  • SERPASIL-ESIDRIX COMPONENT RESERPINE
  • Tox21_300537
  • Rauserpin-Alk
  • Hypertensan
  • CCG-204168
  • Serpaneurona
  • Methyl reserpate
  • 3,4,5-Trimethoxybenzoic acid ester
  • VIXO
  • l'-Carpserp
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-
  • NCGC00091250-07
  • Serpalan (TN)
  • RESERPINE [EP MONOGRAPH]
  • methyl 11,17alpha-dimethoxy-18beta-(3,4,5-trimethoxybenzoyloxy)-3beta,20alpha-yohimbane-16beta-carboxylate
  • EPA Pesticide Chemical Code 123101
  • methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-bis(methyloxy)-18-({[3,4,5-tris(methyloxy)phenyl]carbonyl}oxy)yohimban-16-carboxylate
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-
  • AC-13142
  • esc aspere
  • Reserpine [USAN:INN:BAN:JAN]
  • DEMI-REGROTON COMPONENT RESERPINE
  • YOHIMBAN-16-CARBOXYLIC ACID,11,17-DIMETHOXY-18-((3,4,5-TRIMETHOXYBENZOYL)OXY)-, METHYL ESTER, (3BETA,16BETA,17ALPHA,18BETA,20ALPHA)-
  • BRN 0102014
  • RESERPINUM [WHO-IP LATIN]
  • Hydromox R
  • neose rfin
  • HB1895
  • Roxynoid
  • Raudiford
  • Neoslowten
  • Hydro-Reserpine-50
  • (1S,2R,3R,4aS,13bR,14aS)-methyl 2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
  • Mallopress
  • KBio3_001808
  • Perskleran
  • methyl(1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
  • Idoserp
  • Darebon
  • Methyl (3R,16S,17R,18R,20S)-11,17-dimethoxy-18-(3,4,5-trimethoxybenzoyloxy)yohimban-16-carboxylate
  • Resaltex
  • RESERPINE [USP-RS]
  • HYDROSERPINE PLUS (R-H-H) COMPONENT RESERPINE
  • Carditivo
  • NSC757309
  • LS-1306
  • Rauloydin
  • Serpil
  • (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16- carboxylic acid methyl ester
  • AKOS000277559
  • Tylandril
  • Rauwoleaf
  • VI XO
  • Tensionorme
  • RESERPINE COMPONENT OF DEMI-REGROTON
  • R-e-s
  • SPBio_002870
  • KBio2_005685
  • Methyl reserpate 3,4,5-trimethoxybenzoic acid ester
  • RESERPINE [JAN]
  • Reserpina
  • NCGC00091250-14
  • NAQUIVAL COMPONENT RESERPINE
  • Adelfan
  • SK-Reserpine
  • Chloroserpin-250
  • HMS3677D20
  • Serpazol
  • Spectrum_000109
  • Reserpine, European Pharmacopoeia (EP) Reference Standard
  • methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
  • Briserine
  • D00197
  • rau sedyl
  • Resocalm
  • Abesta
  • 50-55-5
  • Ryser
  • Hydromox-R
  • Abicol
  • Hydro-Fluserpine #1
  • NCGC00091250-02
  • STK801975
  • 3BETA,20ALPHA-YOHIMBAN-16BETA-CARBOXYLIC ACID, 18BETA-HYDROXY-11,17ALPHA-DIMETHOXY-, METHYL ESTER, 3,4,5-TRIMETHOXYBENZOATE
  • Tox21_202395
  • RESERPINE [WHO-IP]
  • DivK1c_000012
  • RESERPINE [VANDF]
  • Neo-antitensol
  • Prestwick2_000875
  • BR164333
  • Regroton
  • nembuserpin
  • Reserpine, United States Pharmacopeia (USP) Reference Standard
  • NCGC00091250-09
  • NCGC00091250-08
  • D0J4JM
  • RESERPINE [HSDB]
  • KBioSS_000549
  • Rau-Sed
  • NCGC00254489-01
  • HY-N0480
  • methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate
  • Chloroserpine-500
  • Rese-lar
  • Sandron
  • .gamma.-Serpine
  • Hydroserp
  • AB01562943_01
  • Serpasil-Esidrix #1
  • Rezide
  • Reserpine [USAN:BAN:INN:JAN]
  • MFCD00005091
  • Usaf cb-27
  • methyl (1S,2R,3R,4aS,13bR,14aS)-2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
  • Sedaraupina
  • Rauvlid
  • component of Metatensin
  • 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-methyl ester 3,4,5-trimethoxybenzoate (ester)
  • RESERPINE [IARC]
  • CAS-50-55-5
  • Caswell No. 722A
  • METHYL (3beta,16beta,17alpha,18beta,20alpha)-11,17-DIMETHOXY-18-((3,4,5-TRIMETHOXYBENZOYL)OXY)YOHIMBAN-16-CARBOXYLATE
  • Serpoid
  • Rauwilid
  • Tox21_111107_1
  • neo-serp
  • MEGxp0_001904
  • Serpyrit
  • Elfanex
  • Serpazide
  • RESERPINE (USP MONOGRAPH)
  • Tefaserpina
  • Tenserpinie
  • Adelphin
  • KBio2_000549
  • Modenol
  • 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester)
  • HMS3413D20
  • l-Carpserp
  • Klimanosid
  • Serpentil
  • Sertensin
  • Methyl reserpate 3,5-trimethoxybenzoic acid ester
  • RESERPINE COMPONENT OF DIUTENSEN-R
  • Prestwick3_000875
  • RESERPINE [WHO-DD]
  • NCGC00260758-01
  • H.R.-50 COMPONENT RESERPINE
  • RESERPINE COMPONENT OF HYDRALAZINE HYDROCHLORIDE-HYDROCHLOROTHIAZIDE-RESERPINE
  • Raudixin
  • YOHIMBAN-16-CARBOXYLIC ACID, 11,17-DIMETHOXY-18-((3,4,5-TRIMETHOXYBENZOYL)OXY)-, METHYL ESTER, (3.BETA.,16.BETA.,17.ALPHA.,18.BETA.,20.ALPHA.)-
  • Roxel
  • RESERPINE COMPONENT OF SALUTENSIN
  • EN300-84477
  • BPBio1_001045
  • SDCCGSBI-0050061.P005
  • loweser p
  • Reserpine, 99%
  • Eberspine
  • Reserpine, Vetec(TM) reagent grade
  • Diutensen-R
  • NSC-757309
  • HYDROPRES COMPONENT RESERPINE
  • HMS500A14
  • EU-0100073
  • 11,17-Dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)yohimban-16-carboxylic acid methyl ester
  • SPECTRUM1500526
  • Serpone
  • EINECS 200-047-9
  • Yohimban-16-carboxylic acid,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3.beta.,16.beta.,17.alpha.,18.beta.,20.alpha.)-
  • Chloroserp-500
  • Alkarau
  • component of Renese R
  • Yohimban-16-carboxylic acid derivative of benz(g)indolo(2,3-a)quinolizine
  • 3P Reserp
  • RESERPINE COMPONENT OF HYDRO-RESERP
  • NS00000355
  • Reserpine (USP:INN:BAN:JAN)
  • methyl (4R)-11,17beta-dimethoxy-18beta-[(3,4,5-trimethoxybenzoyl)oxy]-3beta,20alpha-yohimban-16beta-carboxylate
  • Metatensin
  • Reserpina (INN-Spanish)
  • Hydropres
  • Methyl (3R,16S,17R,18R,20S)-11,17-dimethoxy-18-(3,4,5-trimethoxybenzoyloxy)yohimban-16-carboxylate
物化性质
实验特性
LogP 4.10900
PSA 117.78000
Merck 8145
折射率 177 ° (C=1, DMF)
水溶性 Soluble in water.
沸点 700.1°C at 760mmHg
熔点 265oC (dec.)
蒸气压 0mmHg at 25°C
闪点 377.2°C
溶解度 less than 1 mg/mL at 72° F (NTP, 1992)
浓度 1 pg/μL in methanol: water (1:1)
颜色与性状 淡黄色粉末
稳定性 Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents.
溶解性 易溶于氯仿(约1g/6ml)、四氯甲烷、冰乙酸,溶于苯、乙酸乙酯,微溶于丙酮、甲醇、乙醇(1g/1800ml)、乙醚、乙酸溶液和柠檬酸溶液,极微溶于水。
酸度系数(pKa) 6.6(at 25℃)
比旋光度 -126° (c=1, CHCl3)
光学活性 [α]20/D −123±3°, c = 1% in chloroform
密度 1.32g/cm3
气味 Odorless
计算特性
精确分子量 608.27300
氢键供体数量 1
氢键受体数量 10
可旋转化学键数量 10
同位素质量 608.27338086 g/mol
重原子数量 44
复杂度 1000
同位素原子数量 0
确定原子立构中心数量 6
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
功能3d受体数量 7
有效转子数量 11.6
构象异构体抽样RMSD 1.2
CID构象异构体数量 34
疏水参数计算参考值(XlogP) 4
功能3d供体数量 1
互变异构体数量
功能3d环数量 6
功能3d阳离子数量 2
表面电荷 0
拓扑分子极性表面积 118
分子量 608.7
国际标准相关数据
EINECS 200-047-9
海关数据
海关数据

中国海关编码:

3003909090
生产方法和用途
用途

一,利血平为肾上腺素能神经抑制药,可阻止肾上腺素能神经末稍内介质的贮存,将囊泡中具有升压作用的介质耗竭。硫酸双肼屈嗪为血管扩张药,可松弛小动脉平滑肌,降低外周阻力。 

二,降血压及安定药。降压作用起效慢,但作用持久。

三,该品广泛应用于轻度和中度高血压的治疗。常与噻嗪类药合用以增加疗效。该药能长期服用,耐受用良好。

生产方法

一,该品系由夹竹桃科植物(萝芙木属)全碱浓缩酸性渗透漉液时析出的胶瘃物中提取而得的一种生物碱,由化学合成来制取。但目前合成法尚无工来生产价值,均自萝芙木中提取。取萝芙木酸性渗漉液蒸发浓缩时析出的胶状物质,加乙醇、冰乙酸、获得酸性乙醇溶液,再用氯仿提取得到氯仿溶液,将基利血平转成硝酸盐,再在弱碱性溶液中以丙酮萃取,并经精制而得利血平。由于该品极易氧化变质,整个生产过程均须避光进行。对生药计总收率约0.01%,对胶质计约0.5%。 

二,生物合成

色氨酸是利血平的生物合成途径的起始原料。色氨酸被色氨酸脱羧酶(tryptophandecarboxylase)转化为色胺。色胺在异胡豆苷合成酶(strictosidinesynthetase)的催化下结合裂环马钱子苷(secologanin)合成异胡豆苷(strictosidine)。多种酶催化反应最终使异胡豆苷转化成利血平。

三,全合成

虽然从萝芙木中已可提取出高纯的利血平,全合成生产也是可行的。1958年,伍德沃德成功地以十六步以上反应全合成利血平,成为有机化学的一块里程碑。由于其结构复杂,它已经成为经典化合物,并已成为众多全合成反应的目标,一些替代的方案也不断被发展出来。1989年,利血平立体构象的全合成也被完成。  
相关文献
专业数据库参考
PubChemId 5770
参考资料
Reaxys RN 102015
Beilstein 102014
化合物详情(旧版)

利血平药理药效

利血平是肾上腺素能神经元阻断性抗高血压药。本品通过耗竭周围交感神经末梢的肾上腺素,心、脑及其他组织中的儿茶酚胺和5-羟色胺达到抗高血压、减慢心率和抑制中枢神经系统的作用。利血平作用于下丘脑部位产生镇静作用,但无致嗜睡和麻醉作用,不改变睡眠时脑电图,可缓解高血压病人焦虑、紧张和头痛。实验动物给予低于临床剂量的利血平后,即出现瞳孔缩小、眼睑松弛和下垂、体温过低、胃肠道活动加快等症状。

利血平特点及副作用

利血平[处]口服后降压作用产生缓慢、温和,停药后作消失也慢。口服后3~7天见效,3~4周达高峰,停药后血压在2~6周内回升。该药曾广泛用于轻、中度高血压,特别是与噻嗪类利尿药合用有良效,是目前常用的复方降压药的主要成分之一。常用剂量口服为每日0.25~0.5毫克。肌内注射或静脉注射为 0.5~1.0毫克,注射后约30~60分钟开始产生降压作用,最大作用在3小时,所以重复注射宜在3小时后。 利血平不良反应较多,目前新的具有更多优点的降压药不断上市,该药在高血压的治疗中又很少应用。常见不良反应有鼻塞、口干、抑郁、胃酸增多、腹泻、皮疹等,大剂量可出现面红、心律失常、心绞痛样综合征,心动过缓,偶可产生帕金森综合征。应注意,有精神抑郁性疾病或病史者,有溃疡病病史者、急性局限性肠炎、溃疡性结肠炎、帕金森综合征者禁用。 

利血平的质谱图

利血平/50-55-5的质谱图

扩展阅读
利血平 http://www.biopurify.cn/p-3293.html
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