简介名称和标识符别名信息物化性质安全信息国际标准相关数据海关数据相关文献专业数据库参考参考资料化合物详情（旧版）相关分类相关产品

萘啶酸 | 389-08-2

→现货商城点击进入

中文名称：萘啶酸

英文名称： Nalidixic acid

CAS No.： 389-08-2

分子式： C₁₂H₁₂N₂O₃

分子量： 232.2353

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：萘啶酸结构式

MSDS：萘啶酸MSDS

PubChem CID： 24897864

价格行情：萘啶酸价格

快速询单国内供应商

萘啶酸的其他展现形式

相关化合物

岚香酮酸

BETA-ELEMONIC ACID

CAS No.：28282-25-9
安福萘酸

7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

CAS No.：15180-02-6
7 -羧基萘啶酸

1,8-Naphthyridine-2,6-dicarboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-

CAS No.：1088-16-0
1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid - 1-deoxy-1-(methylamino)hexitol (1:1)

CAS No.：23277-59-0
1,8-Naphthyridine-3-carboxylic acid,1,4-dihydro-4-oxo-7-(1-pyrrolidinyl)-

CAS No.：344340-28-9
1,8-Naphthyridine-3-carboxylic acid,1-ethyl-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

CAS No.：54132-45-5

简介

萘啶酸为7-甲基-1- 乙基-4- 氧代-1,4- 二氢-1,8- 萘啶-3- 羧酸，是一种浅黄色结晶粉末。溶于氯仿，微溶于醇、强碱液，几乎不溶于水和醚。

名称和标识符

MDL	MFCD00006884
InChIKey	MHWLWQUZZRMNGJ-UHFFFAOYSA-N
Inchi	1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
SMILES	O=C1C(C(=O)O[H])=C([H])N(C([H])([H])C([H])([H])[H])C2=C1C([H])=C([H])C(C([H])([H])[H])=N2

别名信息

- 中文别名 -

萘啶酸
萘啶酮酸
3-苄氧基-2.6-二氟苯硼酸
Nalidixic Acid 萘啶酸
Nalidixic acid 萘啶酮酸

WAKO144-06611萘啶酸标准品
奈啶酸
萘啶酸 EP标准品
萘啶酸标准品
萘啶酮酸 USP标准品
萘啶酮酸(CN琼脂冻干配套试剂),0.2g,对多数革兰氏阴性细菌有抑制作用
1-乙基-7-甲基-4-酮-1,8-萘啶-3-羧酸
7-甲基-1-乙基-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸
萘啶酸,1-乙基-7-甲基-4-酮-1,8-萘啶-3-羧酸
1,4-二氢-1-乙基-7-甲基-1,8-萘啶-4-酮-3-羧酸
1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸

- 英文别名 -

Nalidixic acid
1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Cetrimide Nalidixic acid Agar Supplement
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

5,5-Diphenylimidazolidine-2,4-dione
1,4-Dihydro-1-ethyl-7-Methyl-4-oxo-1,-naphthyridine-3-carboxylic acid
3-Carboxy-1-ethyl-7-Methyl-1,8-naphthyridin-4-
cybis
nalix
negram
NOGRAM
poleon
uriben
Urisal
uroman
uroneg
uropan
Nevigramon
Nalidixin
Uronidix
Nalidixate
Innoxalon
Nalitucsan
Nalidixan
Sicmylon
Unaserus
NegGram
Nalidic acid
Nalidixinic acid
Wintomylon
Nalurin
Naxuril
Jicsron
Dixinal
Dixiben
Acide nalidixique
Nalidicron
Specifin
Specifen
Nicelate
Narigix
Urodixin
Uriclar
Uralgin
Kusnarin
Betaxina
Naldixic acid
Acido nalidixico
Acidum nalidixicum
E
Eucistin
Acide nalidixico
Acido nalid
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Acido nalidissico [DCIT]
Nalidixic acid, >=98%
SCHEMBL21736
WIN-18320
Tox21_302754
1-Ethyl-1,8-naphthyridine-3-carboxilic acid
BIDD:GT0529
Nalidixic acid (JP17/USP/INN)
Negram
Cybis
Nalidixic acid, analytical standard
Nalidixic
NALIDIXIC ACID [EP IMPURITY]
SDCCGSBI-0050814.P004
Nogram
Win 18320
HMS2092K04
MLS004820190
1, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-
NCGC00018181-02
HMS3656K05
Acide 1-etil-7-metil-1,8-naftiridin-4-one-3-carbossilico [Italian]
SBI-0050814.P003
NALIDIXIC ACID [WHO-DD]
CHEBI:100147
HMS500C20
AS-13289
NALIDIXIC ACID (MART.)
1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-
Spectrum2_001360
SR-01000003086-6
HMS3374G11
NALIDIXIC ACID [MART.]
Tox21_110835
EINECS 206-864-7
Eucisten
D91720
NCGC00021730-03
NCGC00021730-06
NCGC00018181-06
Acido nalidixico (INN-Spanish)
Q281082
SR-01000003086-10
S2328
1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure [German]
1-Ethyl-1,8-naphthyridine-3-carboxylic acid
HMS1921G10
EN300-20573
NCI-C56199
NCGC00018181-12
VU0239598-6
NALIDIXIC ACID [INN]
HMS2232H24
Pharmakon1600-01500756
D00183
NCI60_041807
WIN 183203
NCGC00018181-04
BB 0242389
SMR000058264
1-ETHYL-7-METHYL-4-OXO-1,4-DIHYDRO[1,8]NAPHTHYRIDINE-3-CARBOXYLIC ACID
SPBio_002034
KBio2_003966
Nalidixic acid 1000 microg/mL in Methanol
Acidum nalidixicum (INN-Latin)
1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxilic acid
Nalidixic acid, meets USP testing specifications
3-CARBOXY-1-ETHYL-7-METHYL-1,8-NAPTHIDIN-4-ONE
Acide nalidixique [INN-French]
1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
389-08-2
CCG-39298
NCGC00018181-07
Prestwick0_000187
KBioGR_001333
1,8-Naphthyridine-3-carboxylic acid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-
HMS561K17
FT-0603390
N0490
MLS000028504
KBio3_001109
Spectrum3_000075
NSC-757432
Nalidixic acid (NegGram)
Uropan
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
NC00494
Uriben
1-ETHYL-7-METHYL-1,4-DIHYDRO-1,8-NAPTHYRIDIN-4-ONE-CARBOXYLIC ACID
SR-01000003086
MLS006011875
Poleon
MLS002303041
Z104478940
MFCD00006884
nalidixic-acid
NSC-82174
Maybridge1_007101
Nalidixic acid, United States Pharmacopeia (USP) Reference Standard
Nalix
CHEMBL5
NCGC00259028-01
DivK1c_000058
NINDS_000058
Wintron
1-Ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid
3-Carboxy-1-ethyl-7-methyl-1,8-naphthidin-4-one
Innoxalomn
SW219624-1
Nalidixic acid, Antibiotic for Culture Media Use Only
NCGC00018181-05
HSDB 3241
1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid
Acid, Nalidixic
NALIDIXIC ACID [MI]
WLN: T66 BN EV JNJ B2 DVQ I1
Oprea1_010545
1-Ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid
Spectrum_000918
1,4-Dihydro-1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid
Lopac0_000837
AKOS000120074
NSC757432
NALIDIXIC ACID [JAN]
NCGC00018181-08
Acide nalidixique (INN-French)
Tox21_201477
NegGram (TN)
KBio2_006534
Acide nalidixico [Italian]
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naph thyridine-3-carboxylic acid
KBioSS_001398
SPECTRUM1500756
Nalidixic acid (USAN:USP:INN:BAN:JAN)
BSPBio_001889
KBio1_000058
WIN 18,320
DTXSID3020912
F0850-6751
5-25-07-00384 (Beilstein Handbook Reference)
N-1200
NCIOpen2_004342
NCGC00021730-07
Uroman
UNII-3B91HWA56M
DTXCID70912
NALIDIXICACID
Spectrum4_000817
InChI=1/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17
Nalidixic acid, European Pharmacopoeia (EP) Reference Standard
NALIDIXIC ACID [USP IMPURITY]
1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO-1,8-NAPTHYRIDINE-3-CARBOXYLIC ACID
BDBM21691
Prestwick2_000187
HY-B0398
BSPBio_000113
Tox21_110835_1
SY049448
Nalidixic acid 100 microg/mL in Acetonitrile
SPBio_001579
Opera_ID_1064
Prestwick1_000187
SR-01000003086-4
Acido nalidixico [INN-Spanish]
Nalidixic acid 100 microg/mL in Methanol
Uroneg
Acidum nalidixicum [INN-Latin]
CAS-389-08-2
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-(1,8)naphthyridine-3-carboxylic acid
MLS001148578
NALIDIXIC ACID [USAN]
NCGC00018181-09
NCGC00021730-04
KBio2_001398
HMS3259O13
CCRIS 2365
nalidixic acid
NCGC00018181-01
Nalidixinsaure
NCGC00021730-05
1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
NALIDIXIC ACID (EP IMPURITY)
NCGC00018181-13
BPBio1_000125
1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure
3-Carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one
DB00779
NALIDIXIC ACID [HSDB]
Nalidixic acid [USAN:USP:INN:BAN:JAN]
BRD-K47886988-323-03-0
Acide 1-etil-7-metil-1,8-naftiridin-4-one-3-carbossilico
BRN 0750515
Prestwick3_000187
UPCMLD-DP129:001
NS00009829
1-ethyl-7-methyl-4-oxo-1
Acido nalidissico
3B91HWA56M
GTPL12773
NCGC00018181-03
NCGC00256581-01
NALIDIXIC ACID [VANDF]
NALIDIXIC ACID [ORANGE BOOK]
IDI1_000058
Acide nalidixique [French]
wil 18,320
SMR004703506
C05079
UPCMLD-DP129
J01MB02
Nalidixane
NSC82174
NCGC00018181-10
NALIDIXIC ACID (USP IMPURITY)
Spectrum5_001540

物化性质

实验特性

LogP	1.42300
PSA	72.19000
Merck	6359
折射率	1.6660 (estimate)
水溶性	0.1 g/L (23 ºC)
沸点	413.1°C at 760 mmHg
熔点	227-229 °C (lit.)
蒸气压	0.0±1.0 mmHg at 25°C
闪点	203.6 °C
溶解度	chloroform: 20 mg/mL, clear
颜色与性状	不可用
稳定性	Stable. Incompatible with strong oxidizing agents.
溶解性	不可用
密度	1.2243 (rough estimate)

计算特性

精确分子量	232.08500
氢键供体数量	1
氢键受体数量	5
可旋转化学键数量	2
同位素质量	232.084792
重原子数量	17
复杂度	378
同位素原子数量	0
确定原子立构中心数量	0
不确定原子立构中心数量	0
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	1.4
互变异构体数量	5
表面电荷	0
拓扑分子极性表面积	70.5

安全信息

符号：	GHS08
RTECS号	QN2885000
WGK Germany	2
安全术语	S22;S24;S36/37;S45
安全说明	S22-S36/37-S45-S24
风险术语	R40; R42/43; R63
危险品标志	Xn
危险品运输编号	NONH for all modes of transport
危害声明	H334
警示性声明	P261,P342+P311
提示语	警告
储存条件	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
危险类别码	22
信号词	Danger
毒性	LD50 in mice (mg/kg): 3300 orally; 500 s.c.; 176 i.v. (Lesher, 1962)
FLUKA BRAND F CODES	8-10-23

国际标准相关数据

EINECS	206-864-7

海关数据

海关编码	2933990090
海关数据	中国海关编码： 2933990090 概述： 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% 申报要素：品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 Summary： 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

海关编码

2933990090

海关数据

中国海关编码：

2933990090

概述：

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

Summary：

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

相关文献

1. Production of clinoptilolite nanorods by glow discharge plasma technique for heterogeneous catalytic ozonation of nalidixic acid
Alireza Khataee,Tannaz Sadeghi Rad,Mehrangiz Fathinia,Sang Woo Joo RSC Adv. 2016 6 20858
2. Synthesis, controlled release and antibacterial studies of nalidixic acid–zinc hydroxide nitrate nanocomposites
Hafezeh Nabipour,Moayad Hossaini Sadr,Nygil Thomas New J. Chem. 2016 40 238
3. Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization
Kaushik Nath Bhaumik,Anasztázia Hetényi,Gábor Olajos,Ana Martins,Réka Spohn,Lukács Németh,Balázs Jojart,Petra Szili,Anett Dunai,Pramod K. Jangir,Lejla Daruka,Imre F?ldesi,Diána Kata,Csaba Pál,Tamás A. Martinek Mol. Syst. Des. Eng. 2022 7 21
4. VIVO complexes with antibacterial quinolone ligands and their interaction with serum proteins
Daniele Sanna,Valeria Ugone,Giuseppe Sciortino,Péter Buglyó,Zsolt Bihari,Péter László Parajdi-Losonczi,Eugenio Garribba Dalton Trans. 2018 47 2164
5. Implementing an OR–NOT (ORN) logic gate with components of the SOS regulatory network of Escherichia coli
Rafael Silva-Rocha,Víctor de Lorenzo Mol. BioSyst. 2011 7 2389
6. Exploring the binding and cleavage activities of nickelII complexes towards DNA and proteins
Manish Kumar,Neetika Lal,Pratibha Mehta Luthra,Dhanraj T. Masram New J. Chem. 2021 45 6693
7. FTIR metabolomic fingerprint reveals different modes of action exerted by active pharmaceutical ingredient based ionic liquids (API-ILs) on Salmonella typhimurium
P. Mester,A. K. Jehle,C. Leeb,R. Kalb,T. Grunert,P. Rossmanith RSC Adv. 2016 6 32220
8. Hydrogen bonding networks of nalidixic acid–copper(ii) complexes
Catarina Bravo,Filipa Galego,Vania André CrystEngComm 2019 21 7199
9. Hydrogen bonding networks of nalidixic acid–copper(ii) complexes
Catarina Bravo,Filipa Galego,Vania André CrystEngComm 2019 21 7199
10. Hydrogen bonding networks of nalidixic acid–copper(ii) complexes
Catarina Bravo,Filipa Galego,Vania André CrystEngComm 2019 21 7199

专业数据库参考

PubChemId	24897864

参考资料

Reaxys RN	750515
Beilstein	750515

化合物详情（旧版）

物理化学性质

熔点 227-229 °C(lit.)

储存条件 0-6°C

溶解度 chloroform: 20 mg/mL, clear，溶于氯仿，微溶于醇、强碱液，几乎不溶于水和醚。

水溶解性 0.1 G/L (23 ºC)

Merck 14,6359

稳定性 Stable. Incompatible with strong oxidizing agents.

性状浅黄色结晶粉末。

生产方法

由2-甲基吡啶制得2-氨基-5-甲基吡啶，再与原甲酸乙酯及丙二酸二乙酯缩合成N-（2-甲基-5-氨基吡啶）甲叉丙二酸二乙酯，然后将其在260-270℃环合后再加入****稀溶液中水解，得到7-甲基-1,8-萘啶-4-羟基-3-羟酸。最后用溴乙烷进行N-烷基化并异构成萘啶酮酸。

产品用途

抗感染药，对大肠杆菌、变形杆菌属等杆菌科细菌有一定的抗菌作用。该品为抗菌剂，能抑制细菌DNA、RNA的合成，用于治疗革兰氏阴性细菌所致的尿道感染。萘啶酮酸是喹诺酮类的第一代抗菌药代表，第二代则以吡哌为代表。第三代喹诺酮类抗菌药物的代表是氟哌酸。

应用领域

化学品安全说明书(MSDS)

储运特性

产品用途

抗感染药，对大肠杆菌、变形杆菌属等杆菌科细菌有一定的抗菌作用

萘啶酸 | 389-08-2

中国海关编码：

概述：

申报要素：

Summary：

平台在线客服