简介名称和标识符别名信息物化性质安全信息国际标准相关数据海关数据相关文献专业数据库参考化合物详情（旧版）相关分类相关产品

薯蓣皂苷 | 19057-60-4

→现货商城点击进入

中文名称：薯蓣皂苷

英文名称： Dioscin

CAS No.： 19057-60-4

分子式： C₄₅H₇₂O₁₆

分子量： 869.0436

植物源：

薯蓣穿山龙穿龙薯蓣

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：薯蓣皂苷结构式

MSDS：薯蓣皂苷MSDS

PubChem CID： 329825065

价格行情：薯蓣皂苷价格

快速询单国内供应商

薯蓣皂苷的其他展现形式

相关化合物

西托糖苷

Daucosterol

CAS No.：474-58-8
薯蓣皂素

Diosgenin

CAS No.：512-04-9
薯蓣皂苷元

yamogenin

CAS No.：512-06-1
麦冬皂苷D

Ophiopogonin D’

CAS No.：65604-80-0
麦冬皂苷 B

Ophiopogonin B

CAS No.：38971-41-4
地索苷

Disogluside

CAS No.：14144-06-0

简介

Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷，针对多种癌细胞有较好的抗癌活性。

名称和标识符

MDL	MFCD02094174
InChIKey	VNONINPVFQTJOC-ZGXDEBHDSA-N
Inchi	1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
SMILES	O1[C@]2(C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])O2)[C@@]([H])(C([H])([H])[H])[C@@]2([H])[C@]1([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])=C4C([H])([H])[C@]([H])(C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H])O[C@@]1([H])[C@@]([H])([C@]([H])([C@@]([H])([C@@]([H])(C([H])([H])O[H])O1)O[C@@]1([H])[C@@]([H])([C@@]([H])([C@]([H])([C@]([H])(C([H])([H])[H])O1)O[H])O[H])O[H])O[H])O[C@@]1([H])[C@@]([H])([C@@]([H])([C@]([H])([C@]([H])(C([H])([H])[H])O1)O[H])O[H])O[H]

别名信息

- 中文别名 -

薯蓣皂苷
薯蓣皂甙
薯蓣皂荚
重楼皂苷III
告达亭甙元

灰毡毛忍冬皂苷乙
薯蓣皂甙薯蓣皂苷
薯蓣皂甙（标准品）
薯蓣皂苷标准品
薯蓣皂苷(P)
薯蓣皂苷（重楼皂苷III）
薯蓣皂苷,Dioscin
薯蓣皂苷、重楼皂苷III
薯蓣皂元
土荆皮提取物
重楼皂苷III(薯蓣皂苷)
分析对照品
薯蓣皂苷薯蓣皂甙
重楼皂甙III
重楼皂苷Ⅲ
阮闢逧ら漠
薯蓣素.薯蓣皂苷
薯蓣皂苷, 来源于薯蓣
DIOSCIN 薯蓣皂苷
薯蓣皂苷； Dioscin； HPLC≥98%
薯蓣皂甙/薯蓣皂苷
薯蓣皂苷/重楼皂苷Ⅲ
薯蓣皂甙(对照品)

- 英文别名 -

Dioscin
beta-d-glucopyranoside,(3-beta,25r)-spirost-5-en-3-ylo-6-deoxy-alpha-l-mannop
collettisideiii
dioscine
yranosyl-(1-2)-o-(6-deoxy-alpha-l-mannopyranosyl)-(1-4))-

DIOSCIN(P)
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-
(25R)-3β-[2-O,4-O-Bis(α-L-rhamnopyranosyl)-β-D-glucopyranosyloxy]spirosta-5-ene
DIOSCIN(P) PrintBack
DIOSCIN(RG)
Polyphyllin III
CCRIS 4123
polyphyllin III
Diosgenin bis-α-L-rhamnopyranosyl-(1→2,1→4)-beta-D-glucopyranoside
[ "" ]
Dioscin (6ci,7ci,8ci)
Dioscin(Collettiside III)
Collettiside III
Dioscin, 98%, from Dioscorea opposita Thunb.
3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]-diosgenin
3-O-[alpha-L-Rhap-(1->4)-[alpha-L-Rhap-(1->2)]-beta-D-Glcp]-diosgenin
(25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside
3B95U4OLWV
Dioscin (Collettiside III)
GTPL840
(+)-DIOSCIN
Collettiside III
CCRIS 4123
DIOSCIN [MI]
3-O-(alpha-L-Rhap-(1->4)-(alpha-L-Rhap-(1->2))-beta-D-Glcp)-diosgenin
Dioscin, >=95% (HPLC)
3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin
beta-D-GLUCOPYRANOSIDE, (3beta,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-ALPHA-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->4))-
Dioscine
CCG-270544
(3beta,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->4))-beta-D-GLUCOPYRANOSIDE
beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1-4))-
(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
GLXC-13125
Diosgenin bis-alpha-L-rhamnopyranosyl)-(1-2 and 1-4)-beta-D-glucopyranoside
DTXSID50903916
CHEBI:74023
Q-100228
3-O-(Rhaalpha1-4(Rhaalpha1-2)Glcbeta)-(25R)-spirost-5-en-3beta-ol
PARIS III
C08897
19057-60-4
3-O-(alpha-L-Rha-(1->4)-(alpha-L-Rha-(1->2))-beta-D-Glc)diosgenin
(25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-(alpha-L-mannopyranosyl-(1->4))-beta-D-glucopyranoside
Q63395447
Collettinside III
3-O-(alpha-L-Rha-(1->4)-(alpha-L-Rha-(1->2))-beta-D-Glc)-diosgenin
(25r)-3beta-[2-O,4-O-bis(alpha-l-rhamnopyranosyl)-beta-d-glucopyranosyloxy]spirosta-5-ene
BDBM50088500
.BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,25R)-SPIROST-5-EN-3-YL O-6- DEOXY-ALPHA-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-.ALPHA.-L- MANNOPYRANOSYL-(1->4))-
[(25R)-Spirost-5-en-3beta-yl]2-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
HY-N0124
DIOSCIN [WHO-DD]
A880409
UNII-3B95U4OLWV
AKOS022168201
3-O-beta-D-alpha-L-Rhamnopyranosyl(1->4)-[alpha-L-rhamnopyranosyl(1->2)]-beta-D-glucopyranoside-diosgenin
SCHEMBL526528
CHEMBL507001
(3.BETA.,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->4))-.BETA.-D-GLUCOPYRANOSIDE
NS00093686
DIOSGENIN 3-O-alpha-L-RHAMNOPYRANOSYL-(1->2)-(alpha-L-RHAMNOPYRANOSYL-(1->4))-beta-D-GLUCOPYRANOSIDE
DIOSGENIN 3-O-.ALPHA.-L-RHAMNOPYRANOSYL-(1->2)-(.ALPHA.-L-RHAMNOPYRANOSYL-(1->4))-.BETA.-D-GLUCOPYRANOSIDE
DTXCID101331877
s2379

物化性质

实验特性

LogP	1.24170
PSA	235.68000
折射率	1.613
沸点	No data available
熔点	275～277℃
闪点	No data available
颜色与性状	Powder
比旋光度	D13 -115° (c = 0.373 in ethanol)
密度	1.3900

计算特性

精确分子量	868.48200
氢键供体数量	8
氢键受体数量	16
可旋转化学键数量	7
同位素质量	868.482
重原子数量	61
复杂度	1600
同位素原子数量	0
确定原子立构中心数量	26
不确定原子立构中心数量	0
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	1.3
拓扑分子极性表面积	236
分子量	869.0

安全信息

安全说明	24/25
危险品运输编号	NONH for all modes of transport
危害声明	H303+H313+H333
警示性声明	P264+P280+P305+P351+P338+P337+P313
储存条件	2-8°C
信号词	warning

国际标准相关数据

EINECS	4123

海关数据

海关编码	29389090

相关文献

1. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control
Yujie Zhong,Jiayu Liu,Dianjun Sun,Tianmin Guo,Yanpeng Yao,Xiaodong Xia,Chao Shi,Xiaoli Peng Food Funct. 2022 13 3660
2. Inhibitory effects of dioscin on cytochrome P450 enzymes
Xufeng Tao,Lingli Zheng,Yan Qi,Youwei Xu,Lina Xu,Lianhong Yin,Xu Han,Kexin Liu,Jinyong Peng RSC Adv. 2014 4 54026
3. iTRAQ-based proteomics for studying the effects of dioscin against nonalcoholic fatty liver disease in rats
Lina Xu,Yongli Wei,Deshi Dong,Lianhong Yin,Yan Qi,Xu Han,Youwei Xu,Yanyan Zhao,Kexin Liu,Jinyong Peng RSC Adv. 2014 4 30704
4. Quantitative chemical proteomics for investigating the biomarkers of dioscin against liver fibrosis caused by CCl4 in rats
Xiaoling Zhang,Lina Xu,Lianhong Yin,Yan Qi,Youwei Xu,Xu Han,Jinyong Peng Chem. Commun. 2015 51 11064
5. New steroid saponins from Dioscorea zingiberensis yam and their medicinal use against I/R via anti-inflammatory effect
Zhaowei Xue,Zhen Cao,Ming Jin,Xinxin Zhang,Xinrui Wang,Jianwei Dou,Yuhong Zhu,Yoichiro Ito,Zengjun Guo Food Funct. 2021 12 8314
6. The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy
Chengni Jin,Xin Miao,Yujie Zhong,Jiahui Han,Qi Liu,Jiachang Zhu,Xiaodong Xia,Xiaoli Peng Food Funct. 2020 11 7456
7. Efficient enzyme-catalyzed production of diosgenin: inspired by the biotransformation mechanisms of steroid saponins in Talaromyces stollii CLY-6
Leiyu Cheng,Han Zhang,Haiyang Cui,Mehdi D. Davari,Bin Wei,Wenya Wang,Qipeng Yuan Green Chem. 2021 23 5896
8. Discovery of anti-inflammatory components from Guge Fengtong tablet based on inflammatory markers and exploration of its molecular mechanism
Qun Liu,Zhen Wang,Le-Le Liu,Ping Li,E-Hu Liu RSC Adv. 2016 6 96039
9. Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS
Xiao-Lan Cheng,Lian-Wen Qi,Qi Wang,Xin-Guang Liu,Besma Boubertakh,Jin-Yi Wan,E-Hu Liu,Ping Li Analyst 2013 138 2279
10. Conversion of furostanol saponins into spirostanol saponins improves the yield of diosgenin from Dioscorea zingiberensis by acid hydrolysis
Xu Pang,Hong Zhi Huang,Yang Zhao,Cheng-Qi Xiong,Li Yan Yu,Bai-Ping Ma RSC Adv. 2015 5 4831

专业数据库参考

PubChemId	329825065

化合物详情（旧版）

薯蓣皂苷物理化学性质

外观性状：白色结晶粉末
密度： 1.39g/cm3
熔点：294～296℃
分解点275～277℃
旋光度：-115°(C=0.373, 乙醇)
鉴定方法：Mass, NMR
分析方法：HPLC-DAD or/and HPLC-ELSD
溶解性：不溶于水、石油醚、苯，可溶于甲醇、乙醇、醋酸，微溶于丙酮、戊醇。

薯蓣皂苷提取来源

薯蓣科植物穿龙薯蓣Dioscorea Nipponica。多年生缠绕草本，长达5m。根茎横生，圆柱形，木质，多分枝，栓皮层显著剥离。茎左旋，圆柱形，近无毛。单叶互生；叶长10-20cm；叶片掌状心形，变化较大，茎基部叶长10-15cm，宽9-13cm，边缘作不等大的三角状浅裂、中裂或深裂，先端叶片小，近于全缘，叶表面黄绿色，有光泽，无毛或有稀疏的白色细柔毛，尤以脉上较密。花单性，雌雄异株。雄花序为腋生的穗状花序，花序基部常由2-4朵集成小伞状，花序顶端常为单花；苞片披针形，先端渐尖，短于花被；花被碟形，6裂，裂片先端钝圆；雄蕊6，着生于花被裂片的中央，花药内向。雌花序穗状，单生；花被6裂，裂片披针形；雌蕊柱头3裂，裂片再2裂。蒴果成熟后枯黄色，三棱形，先端凹入，基部近圆形，每棱翅状，大小不一，一般长约2cm，宽约1.5cm。种子每室2，有时仅1颗发育，着生于中轴基部，四周有不等的薄膜状翅，上方呈长方形，长约比宽大2倍。花期6-8月。

薯蓣皂苷药理药效

抗肿瘤、抗血栓形成、抗过敏、抗病毒和抗休克。具有抗炎、抗肿瘤、抗病毒、降低胆固醇、降低血压、杀软体动物、抗生育等功效。可用于气管炎的治疗。有杀昆虫和抗须癣毛菌等真菌的作用。其中所含的过氧化分解酶，具有明显的抗衰老作用。久服可祛脸上瘢痕，并让肌肤柔嫩润滑。可作为合成甾体激素及避孕药的原料。

薯蓣皂素是合成甾体激素药物的前体，是重要的甾体激素药用中间体醋酸妊娠双烯醇酮的原料，由它可以合成氢化可的松、强的松、炔诺酮、肤轻松、地塞米松等各类甾体药物。

薯蓣皂苷是甾体总皂苷的一种，在薯蓣科植物中含量最为丰富，现代研究证实其具有抗肿瘤、改善心血管功能、调节免疫、抗血小板聚集、降血脂等多种生理作用，同时也是目前合成各种甾体激素类药物的重要原料。

1.抗肿瘤作用

薯蓣皂苷可以通过抑制瘤细胞分裂、增殖，诱导瘤细胞分化，凋亡，增强抑癌基因表达等途径来抑制肿瘤的生长，从而延缓肿瘤的进展速度，提高肿瘤患者的生存率和生活质量。薯蓣皂苷可明显抑制白血病细胞增殖，并对白血病细胞类型无明显选择性，其对白血病细胞的抑制作用与长春新碱比较，有明显优势。

2.对心血管系统的作用

薯蓣皂苷还能够通过不同途径改善心肌损伤，保护心肌细胞的抗氧化作用，减轻心肌细胞钙超载，保护缺氧心肌作用。

薯蓣皂苷有提高抗氧化酶活性，抑制自由基产生的抗氧化能力，从而证实薯蓣皂苷可通过抗氧化作用发挥对缺氧/复氧心肌细胞的保护作用。

具有减轻心肌细胞钙超载，保护缺氧心肌作用。

3.调节作用

薯蓣皂苷能通过不同途径调节机体免疫，对体液免疫和细胞免疫均有明显的调节作用。