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链脲霉素 | 18883-66-4

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中文名称：链脲霉素

英文名称： Streptozotocin

CAS No.： 18883-66-4

分子式： C₈H₁₅N₃O₇

分子量： 265.2206

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：链脲霉素结构式

MSDS：链脲霉素MSDS

PubChem CID： 329830222

价格行情：链脲霉素价格

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链脲霉素的其他展现形式

相关化合物

 

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简介

链脲霉素又叫链佐星（streptozocin）化学名为2-脱氧-2-[[(甲基亚硝基氨基)羰基]-氨基]-D-吡喃葡萄糖，分子式为C8H15N3O7，分子量为265.22100，淡黄色结晶性粉末，易溶于水，但其水溶液在室温下极不稳定，可在半小时后分解为气体而挥发掉，故需现用现配。溶于较低度醇和酮，不溶于极性的有机溶剂。

名称和标识符

MDL	MFCD00006607
InChIKey	ZSJLQEPLLKMAKR-GKHCUFPYSA-N
Inchi	1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
SMILES	O1[C@@]([H])([C@@]([H])([C@]([H])([C@@]([H])([C@@]1([H])C([H])([H])O[H])O[H])O[H])N([H])C(N(C([H])([H])[H])N=O)=O)O[H]
BRN	2060675

别名信息

- 中文别名 -

链脲霉素
链脲佐菌素
链氮霉素
链脲菌素
2-脱氧-2-(((甲基亚硝基氨基)羰基)-氨基)-D-吡喃葡萄糖

Streptozocin (STZ) 链脲佐菌素
链脲菌素链脲佐菌素
链脲菌素(STZ)
链脲菌佐素
2-脱氧-2-[[(甲基亚硝基氨基)羰基]-氨基]-D-吡喃葡萄糖
链脲佐菌素,2-脱氧-2-[[(甲基亚硝基氨基)羰基]-氨基]-D-吡喃葡萄糖
链佐星
链唑霉素
STZ链脲菌素
链脲佐菌素(标准品)

- 英文别名 -

Streptozocin
2-desoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose
2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-d-glucose
Streptozotocin
Streptozocin (STZ)

Streptozotocin (STZ)
N-(Methylnitrosocarbamoyl)-α-D-glucosamine
STR
strz
STZ
U 9889
U-9889
ZANOSAR
2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
nsc85998
nsc-85598
nsc-85998
nci-c03167
streptozosin
Streptozocinum
Streptozocine
Streptozocinium
Estreptozocina
streptozotocin (stz)
N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff
Streptozoticin
8H27GUR065
DSSTox_CID_1282
DSSTox_RID_76055
DSSTox_GSID_21282
2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
alkylating agent
binds to DNA
1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)ure
KBio1_000531
SBI-0051517.P003
SR-05000001720-2
DTXSID2021282
N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine
Zanosar (TN)
BSPBio_002734
A937380
NINDS_000531
Streptozocin, >=98.0% (HPLC)
Streptozotocine
C8H15N3O7
HMS501K13
KBioSS_001440
2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose
SPBio_000243
HMS2097C06
UNII-8H27GUR065
CHEBI:9288
2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Tox21_302974
2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose
Tox21_201859
NCGC00178500-02
NCGC00256594-01
NCGC00259408-01
2-deoxy-2-((methyl(nitroso)carbamoyl)amino)-alpha-D-glucopyranose
AB00052092_05
streptozocin
N-(METHYLNITROSOCARBAMOYL)-A-D-GLUCOSAMINE
N-D-Glucosyl-(2)-N'-nitrosomethylurea
Streptozocin, >=75% alpha-anomer basis, >=98% (HPLC), powder
18883-66-4
Q257331
1-Methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-3-yl)urea
HMS2092I09
SMP1_000282
KBioGR_001768
KBio3_001954
Spectrum3_001087
.ALPHA.-STREPTOZOCIN
s1312
EN300-7480749
MLS004774123
NCGC00178500-01
N-D-GLUCOSYL(2)-N'-NITROSOMETHYLHARNSTOFF
C07313
SR-01000939745-3
IDI1_000531
alpha-D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-
1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)urea
66395-18-4
Tox21_110585_1
KBio2_006576
Streptozocin (JAN/USAN/INN)
AKOS025310730
L01AD04
2-Desoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
NSC-757321
.ALPHA.-D-GLUCOPYRANOSE, 2-DEOXY-2-(((METHYLNITROSOAMINO)CARBONYL)AMINO)-
AB00513906
Spectrum_000960
AB00052092-03
3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
NSC757321
SW199198-2
NCGC00178500-04
STREPTOZOTOCIN
2-deoxy-2-(((methylnitrosamino)-carbonyl)amino)-D-glucopyranose
Epitope ID:134282
2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
HMS3714C06
NCGC00178500-03
CAS-18883-66-4
DTXCID701282
KBio2_001440
DivK1c_000531
Prestwick3_000732
1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
BSPBio_000684
alpha-Streptozocin
W-201687
2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-alpha-D-glucopyranose
NCGC00016738-01
SMR001233317
HB4097
SR-01000939745
Spectrum5_001047
Tox21_110585
Streptozocin
Streptozotocin
BPBio1_000754
AB00052092_04
DB00428
KBio2_004008
MFCD00006607
Streptozotocin
U 9889
1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]urea
2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose
CCG-39870
SCHEMBL4748
BCBcMAP01_000142
SR-05000001720-1
SPECTRUM1500543
NS00011535
SR-05000001720
Streptozocin, Vetec(TM) reagent grade, 98%, powder
Spectrum2_000062
D05932
HMS1921A07
Pharmakon1600-01500543
NCGC00178500-07
Spectrum4_001244
Zanosar
2-Deoxy-2-(3-methyl-3-nitrosoureido)-.alpha.(and.beta.)-D-glucopyranose
D-Glucose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-
D-Glucopyranose, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-

物化性质

实验特性

LogP	-2.50000
PSA	151.92000
Merck	13,8912
折射率	1.6500 (estimate)
水溶性	溶解
沸点	408.44°C (rough estimate)
熔点	121 °C (dec.) (lit.)
闪点	°C
溶解度	生物体外In Vitro:DMSO溶解度130 mg/mL(490.16 mM;Need ultrasonic)H2O : 113.3 mg/mL(427.19 mM;Need ultrasonic and warming)
颜色与性状	Powder
溶解性	溶于水，低碳醇和酮。
敏感性	Hygroscopic
比旋光度	D25 +39°
密度	1.4410 (rough estimate)

计算特性

精确分子量	265.09100
氢键供体数量	5
氢键受体数量	8
可旋转化学键数量	2
同位素质量	265.091
重原子数量	18
复杂度	315
同位素原子数量	0
确定原子立构中心数量	5
不确定原子立构中心数量	0
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	-1.4
互变异构体数量	2
表面电荷	0
拓扑分子极性表面积	152

安全信息

符号：	GHS08
RTECS号	LZ5775000
WGK Germany	3
安全术语	6.1(b)
安全说明	36/37-53-45-36-22
包装等级	III
包装类别	III
风险术语	R22; R45; R46; R61
危险等级	6.1(b)
危险品标志	Xn
危险品运输编号	3249
危害声明	H350
警示性声明	P201,P308+P313
储存条件	−20°C
PackingGroup	Ⅲ
危险类别码	45
信号词	Danger
毒性	LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki)
HazardClass	9
FLUKA BRAND F CODES	3-10-21

国际标准相关数据

EINECS	242-646-8

海关数据

海关编码	2932999099
海关数据	中国海关编码： 2932999099 概述： 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% 申报要素：品名, 成分含量, 用途 Summary： 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

海关编码

2932999099

海关数据