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度他雄胺 | 164656-23-9

度他雄胺
Dutasteride
164656-23-9
C27H30F6N2O2
528.5297
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:度他雄胺结构式
6918296
度他雄胺价格
简介
Dutasteride (GG745)是5α 还原酶同工酶 (5α-reductase isozymes) 抑制剂,还可能因其结构域DHT相似对雄激素受体 (AR) 产生脱靶效应。
名称和标识符
MDL MFCD00937869
InChIKey JWJOTENAMICLJG-QWBYCMEYSA-N
Inchi 1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
SMILES FC(C1C([H])=C([H])C(C(F)(F)F)=C([H])C=1N([H])C([C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])[C@@](C([H])=C([H])C(N4[H])=O)(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]21C([H])([H])[H])=O)(F)F
别名信息
- 中文别名 -
  • 度他雄胺
  • * 度他雄胺
  • N-亚硝基双(2-羰基丙基)胺
  • 丙酸倍氯米松
  • 度他雄胺 USP标准品
  • 度他雄胺分离度用混合物
  • 度他雄胺粉
  • 度他雄胺杂质
  • 度他雄胺杂质及标准品
  • 胱胺硫酸盐
  • 他克莫司
  • 度他雄胺醋
  • 度他雄胺及中间体
  • 度他雄胺(标准品)
- 英文别名 -
  • Dutasteride
  • (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide
  • (4aR,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
  • (4aR,6aS,7S)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
  • Avodart
  • Duagen
  • GG 745
  • GI198745
  • Avolve
  • (5α,17β)-
  • Dutasteride API
  • GG-745, GI-198745,
  • Dutasteride (200 mg)
  • Dutasteride(Avodart)
  • GI 198745
  • O0J6XJN02I
  • Dutasteride, 99%
  • Avidart
  • Avidart
  • (4ar,4bs,6as,7s,9as,9bs,11ar)-n-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1h-indeno[5,4-f]quinoline-7-carboxamide
  • (4ar,4bs,6as,7s,9as,9bs,11ar)-n-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1h-indeno[5,4-f]quinoline-7-carboxamide
  • JALYN COMPONENT DUTASTERIDE
  • JALYN COMPONENT DUTASTERIDE
  • BCP02344
  • BCP02344
  • EX-A1952
  • EX-A1952
  • alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
  • alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
  • DUTASTERIDE [WHO-DD]
  • DUTASTERIDE [WHO-DD]
  • DUTASTERIDE (USP-RS)
  • DUTASTERIDE (USP-RS)
  • Dutasteride (JAN/USP/INN)
  • Dutasteride (JAN/USP/INN)
  • (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • 1H-Indeno(5,4-f)quinoline-7-carboxamide, N-(2,5-bis(trifluoromethyl)phenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
  • 1H-Indeno(5,4-f)quinoline-7-carboxamide, N-(2,5-bis(trifluoromethyl)phenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
  • NCGC00164571-01
  • NCGC00164571-01
  • UNII-O0J6XJN02I
  • UNII-O0J6XJN02I
  • BD164398
  • BD164398
  • Dutasteride for system suitability, European Pharmacopoeia (EP) Reference Standard
  • GS-3565
  • Dutasteride for system suitability, European Pharmacopoeia (EP) Reference Standard
  • GS-3565
  • Dutasteride, >=98% (HPLC)
  • Dutasteride, >=98% (HPLC)
  • Z1558504346
  • DUTASTERIDE (MART.)
  • Z1558504346
  • CHEMBL1200969
  • DUTASTERIDE (MART.)
  • 164656-23-9
  • CHEMBL1200969
  • DUTASTERIDE [MART.]
  • 164656-23-9
  • BCPP000248
  • DUTASTERIDE [MART.]
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H,11H,11aH-indeno[5,4-f]quinoline-7-carboxamide
  • BCPP000248
  • DTXSID8046452
  • CS-1542
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-bis(trifluoromethyl)phenyl]-4a,6a-dimethyl-2-oxo-1H,2H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H,11H,11aH-indeno[5,4-f]quinoline-7-carboxamide
  • Dutasteride, European Pharmacopoeia (EP) Reference Standard
  • DTXSID8046452
  • NSC 759880
  • CS-1542
  • Q-201052
  • Dutasteride, European Pharmacopoeia (EP) Reference Standard
  • CHEBI:521033
  • NSC 759880
  • DUTASTERIDE [USP-RS]
  • Q-201052
  • AKOS015920136
  • CHEBI:521033
  • D5973
  • DUTASTERIDE [USP-RS]
  • NSC 740477
  • AKOS015920136
  • (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
  • D5973
  • A810580
  • NSC 740477
  • D03820
  • (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoromethyl)phenyl]-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
  • Dutasteride- Bio-X
  • A810580
  • (1S,3aS,3bS,5aR,9aR,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
  • D03820
  • GG-745
  • AKOS015924431
  • Dutasteride- Bio-X
  • AB01274774-01
  • (1S,3aS,3bS,5aR,9aR,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
  • DUTASTERIDE [USP MONOGRAPH]
  • GG-745
  • NSC740477
  • AKOS015924431
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-Bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
  • AB01274774-01
  • DTXCID6026452
  • DUTASTERIDE [USP MONOGRAPH]
  • BDBM50340481
  • NSC740477
  • AB01274774_02
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-Bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
  • Dutasteride, United States Pharmacopeia (USP) Reference Standard
  • DTXCID6026452
  • Tox21_112199
  • BDBM50340481
  • DUTASTERIDE [INN]
  • AB01274774_02
  • G04CB02
  • Dutasteride, United States Pharmacopeia (USP) Reference Standard
  • Q424760
  • Tox21_112199
  • BRD-K30373883-001-02-8
  • DUTASTERIDE [INN]
  • (5alpha,17beta)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • G04CB02
  • dutasteridum
  • Q424760
  • s1202
  • BRD-K30373883-001-02-8
  • BCP9000630
  • (5alpha,17beta)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • 17beta-N-(2,5-bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one
  • dutasteridum
  • .ALPHA.,.ALPHA.,.ALPHA.,.ALPHA.',.ALPHA.',.ALPHA.'-HEXAFLUORO-3-OXO-4-AZA-5.ALPHA.-ANDROST-1-ENE-17.BETA.-CARBOXY-2',5'-XYLIDIDE
  • s1202
  • NSC-740477
  • BCP9000630
  • 17beta-N-(2,5-bis(trifluoromethyl))phenyl-carbamoyl-4-aza-5alpha-androst-1-en-3-one
  • DUTASTERIDE [VANDF]
  • CAS-164656-23-9
  • .ALPHA.,.ALPHA.,.ALPHA.,.ALPHA.',.ALPHA.',.ALPHA.'-HEXAFLUORO-3-OXO-4-AZA-5.ALPHA.-ANDROST-1-ENE-17.BETA.-CARBOXY-2',5'-XYLIDIDE
  • Dutasteride [USAN:INN:BAN]
  • NSC-740477
  • SCHEMBL5903
  • DUTASTERIDE [VANDF]
  • HY-13613
  • CAS-164656-23-9
  • Dutasteride [USAN]
  • Dutasteride [USAN:INN:BAN]
  • (5.ALPHA.,17.BETA.)-N-(2,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-OXO-4-AZAANDROST-1-ENE-17-CARBOXAMIDE
  • SCHEMBL5903
  • DUTASTERIDE [EP MONOGRAPH]
  • HY-13613
  • GI-198745
  • Dutasteride [USAN]
  • DUTASTERIDE (USP MONOGRAPH)
  • (5.ALPHA.,17.BETA.)-N-(2,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-OXO-4-AZAANDROST-1-ENE-17-CARBOXAMIDE
  • 4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-
  • DUTASTERIDE [EP MONOGRAPH]
  • Dutasterida
  • GI-198745
  • MFCD00937869
  • DUTASTERIDE (USP MONOGRAPH)
  • DB01126
  • 4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-
  • (5alpha,17beta)-N-{2,5-bis(trifluoromethyl)-phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • EN300-124223
  • Dutasterida
  • GI-198745X
  • MFCD00937869
  • DUTASTERIDE COMPONENT OF JALYN
  • DB01126
  • DUTASTERIDE (EP MONOGRAPH)
  • (5alpha,17beta)-N-{2,5-bis(trifluoromethyl)-phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • NSC-759880
  • EN300-124223
  • (5.alpha.,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • dutasteride
  • Avodart
  • GI-198745X
  • Duastride
  • DUTASTERIDE COMPONENT OF JALYN
  • DUTASTERIDE [JAN]
  • DUTASTERIDE (EP MONOGRAPH)
  • (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
  • NSC-759880
  • GTPL7457
  • (5.alpha.,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • dutasteride
  • Avodart
  • Avodart (TN)
  • Duastride
  • CCG-269904
  • DUTASTERIDE [JAN]
  • N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
  • (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
  • DUTASTERIDE [ORANGE BOOK]
  • GTPL7457
  • 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
  • Avodart (TN)
  • Dutasteride for system suitability
  • CCG-269904
  • DUTASTERIDE [MI]
  • N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
  • (5alpha,17beta)-N-{2,5-Bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide
  • DUTASTERIDE [ORANGE BOOK]
  • DUTASTERIDE
  • 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
  • Dutasteride for system suitability
  • DUTASTERIDE [MI]
  • (5alpha,17beta)-N-{2,5-Bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide
  • DUTASTERIDE
物化性质
实验特性
LogP 6.97790
PSA 58.20000
折射率 1.523
沸点 620.3°C at 760 mmHg
熔点 242-250 ºC
闪点 329 °C
溶解度 DMSO: soluble2mg/mL, clear
颜色与性状 Powder
密度 1.303
计算特性
精确分子量 528.22100
氢键供体数量 2
氢键受体数量 8
可旋转化学键数量 2
同位素质量 528.221147
重原子数量 37
复杂度 964
同位素原子数量 0
确定原子立构中心数量 7
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 5.4
拓扑分子极性表面积 58.2
国际标准相关数据
EINECS 238-483-7
海关数据
海关编码 2942000000
海关数据

中国海关编码:

2933990090

概述:

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素:

品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

Summary:

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

生产方法和用途
用途 度他雄胺,医药原料和中间体。用于前列腺肿大、男性型脱发、脂溢性脱发、遗传性脱发。
合成路线

合成路线:1 步

反应条件:
参考文献:
Impurity profile study of dutasteride
Satyanarayana, K.; Srinivas, K.; Himabindu, V.; Reddy, G. Mahesh, Pharmazie, 2007, 62(10), 743-746
相关文献
专业数据库参考
PubChemId 6918296
化合物详情(旧版)

物理化学性质

密度: 1.303g/cm3
熔点: 242-250℃
沸点: 620.313℃ at 760 mmHg
闪点: 328.954℃
蒸汽压:0mmHg at 25℃

产品用途

应用领域







上下游产品信息




化学品安全说明书(MSDS)



储运特性





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