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盐酸维拉帕米 | 152-11-4

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中文名称：盐酸维拉帕米

英文名称： Verapamil hydrochloride

CAS No.： 152-11-4

分子式： C₂₇H₃₉ClN₂O₄

分子量： 491.0626

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：盐酸维拉帕米结构式

MSDS：盐酸维拉帕米MSDS

PubChem CID： 62969

价格行情：盐酸维拉帕米价格

快速询单国内供应商

盐酸维拉帕米的其他展现形式

相关化合物

维拉帕米

verapamil

CAS No.：52-53-9
戈洛帕米

5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile

CAS No.：16662-47-8
达加帕米

Benzeneacetonitrile, a-dodecyl-3,4,5-trimethoxy-a-[3-[[2-(3-methoxyphenyl)ethyl]methylamino]propyl]-

CAS No.：85247-76-3
S-维拉帕米

S(-)-VERAPAMIL

CAS No.：36622-28-3
(2s)-2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile

CAS No.：38099-34-2
Benzeneacetonitrile,a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-hydroxy-3-methoxy-a-(1-methylethyl)-, (R)-

CAS No.：139561-54-9

简介

Verapamil hydrochloride ((±)-Verapamil hydrochloride) 是一种钙通道 (calcium channel) 阻滞剂，是一种有效的口服活性的第一代 P 糖蛋白 (P-gp) 抑制剂。Verapamil hydrochloride 能也抑制 CYP3A4，并可用于高血压，心律不齐和心绞痛的研究。

名称和标识符

MDL	MFCD00055208
InChIKey	DOQPXTMNIUCOSY-UHFFFAOYSA-N
Inchi	1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
SMILES	Cl[H].O(C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(C#N)(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1C([H])=C([H])C(=C(C=1[H])OC([H])([H])[H])OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])OC([H])([H])[H]

别名信息

- 中文别名 -

盐酸维拉帕米
alpha-[3-[[2-(3,4-二甲氧苯基)乙基]甲氨基]丙基]-alpha-异丙基-3,4-二甲氧基苯乙腈盐酸盐
维拉帕米盐酸盐
戊脉安盐酸盐
异搏定盐酸盐

异搏停盐酸盐
Verapamil Hydrochloride 维拉帕米盐酸盐
盐酸维拉帕米 EP标准品
盐酸维拉帕米 USP标准品
盐酸维拉帕米标准品
盐酸维拉帕米、维拉帕米盐酸盐
盐酸维拉帕米杂质对照品
盐酸盐维拉帕米标准品
Α-[3-[[2-(3,4-二甲氧苯基)乙基]甲氨基]丙基]-Α-异丙基-3,4-二甲氧基苯乙腈盐酸盐
苯噻嗪
维拉帕米,盐酸D7
盐酸维拉帕米,(±)-Verapamil hydrochloride
5-[(3,4-二甲氧基苯乙基)甲氨基]-2-(3,4-二甲氧基苯基)-2-异丙基戊腈盐酸盐
戊脉安
维拉帕米盐酸
盐酸维拉帕米(标准品)
盐酸维拉帕米, 一种L型钙通道阻断剂
盐酸维拉帕米戊脉安

- 英文别名 -

VERAPAMIL HYDROCHLORIDE
alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-
benzeneacetonitrile hydrochloride
5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE (+/-)-VERAPAMIL HYDROCHLORIDE
CALAN

IPROVERATRIL
ISOPTIN
(+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE
5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE
alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride
ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE
5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE
Verapamil HCl
finoptin
iproveratrilhydrochloride
izoptinhydrochloride
(±)-Verapamil hydrochloride
(+-)-VERAPAMIL HYDROCHLORIDE
(±)-Verapamil hydrochlorid
2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)-ethyl](methyl)amino]-2-isopropylpentanenitrile hydrochloride
Verapamil (hydrochloride)
Verapamil Hydrochlor
Verapamil hydrochloride solution
(+/-)-Verapamil hydrochloride
(-)-VerapaMil hydrochloride
(‘±)-Verapamil hydrochloride
Verapamil hydrochloride,α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrilehydrochloride
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2
manidon
lu20175
Rositol
cordilox
Hormitol
Magotiron
Verapamil HCI
d-365hydrochloride
verapamilchloridrate
Calcan hydrochloride
Cardibeltin
Veroptinstada
Cardioprotect
Cardiabeltin
Vetrimil
Vasopten
Vasomil
Jenapamil
Isoptino
Corpamil
Coraver
Caveril
Veratensin
Verasal
Veraloc
Veracor
Verabeta
Praecicor
Hexasoptin
Verasifar
Veramil
Ikapress
Harteze
Durasoptin
Civicor
Calaptin
Verdilac
Verapin
Verahexal
Robatelan
Lodixal
Inselon
Flamon
Elthon
Vortac
Univex
Ikacor
Rapam
Anpec
Ormil
Verapamil
CP-16533-1 hydrochloride
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride
CP-16533-1 hydrochloride
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride
Verapamil hydrochloride
Verapamil Basics
VERAPAMIL HYDROCHLORIDE [USAN]
Q27291481
D-365 hydrochloride
Cordilox
(+-)-Verapamil hydrochloride
Verapamil chloridrate
MLS002222213
(+-)-5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
?VERAPAMIL HYDROCHLORIDE
Calan (TN)
NS00079093
Quasar
D78147
VERAPAMIL HYDROCHLORIDE (EP MONOGRAPH)
VERAPAMIL HYDROCHLORIDE (EP IMPURITY)
D00619
MLS000069485
( inverted exclamation markA)-Verapamil hydrochlorid
Verelan
Isotopin hydrochloride
Novapamyl LP
AS-16018
( inverted question mark)-Verapamil hydrochloride
NCGC00024710-03
SR-01000000050-2
NSC-759589
?-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-?-(1-methylethyl)benzeneacetonitrile hydrochloride
BENZENEACETONITRILE, alpha-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-alpha-(1-METHYLETHYL)-, MONOHYDROCHLORIDE, (+/-)-
Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (+-)-
NSC657799
SY073165
A816666
(+/-)-Verapamil, Hydrochloride - CAS 152-11-4
CHEBI:53188
5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride
23313-68-0
Veracaps SR
(+/-)-Verapamil hydrochloride, >=99% (titration), powder
NSC272366
alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl) benzeneacetonitrile hydrochloride
VERAPAMIL HYDROCHLORIDE [MART.]
FT-0675800
Q-201923
VERAPAMIL HYDROCHLORIDE [WHO-IP]
5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrilehydrochloride
(?)-Verapamil hydrochloride
EINECS 205-800-5
NSC 272366
AC-8483
Verapamil Nordic
V 4629
Dilacoran HTA
152-11-4
Pharmakon1600-02300307
Verapress 240 SR
Prestwick_440
LU-20175
VERAPAMIL HYDROCHLORIDE (USP MONOGRAPH)
BCP06465
NCGC00261922-01
CAS-152-11-4
EN300-124002
DTXCID0014095
VERAPAMIL HYDROCHLORIDE [HSDB]
MFCD00055208
VERAPAMIL HYDROCHLORIDE (MART.)
HMS1568M04
Verapamil SR
rac-4-cyano-4-(3,4-dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N,5-dimethylhexan-1-aminium chloride
NSC-657799
AKOS005267117
SR-01000000050-4
Cardiagutt
HMS1922J16
VERAPAMIL HYDROCHLORIDE [EP MONOGRAPH]
Verapamil Henning
Verapamili hydrochloridum
Apo-Verap
Verelan SR
Hexasoptin Retard
Tox21_201180
Covera
verapamil.hcl
Verapamil Verla
(+/-)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
s4202
Calaptin 240 SR
DOQPXTMNIUCOSY-UHFFFAOYSA-N
Tox21_501237
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile hydrochloride
NCGC00094479-05
Arpamyl LP
SR-01000000050
Verapamil Riker
MLS001055442
FT-0603360
Nu-Verap
Vasolan (TN)
Isoptin Retard
Benzeneacetonitrile,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, monohydrochloride
Verelan PM
Verapamil Hydrochloride,(S)
Covera-HS
NCGC00094479-02
Verapamil Acis
NCGC00094479-03
VERAPAMIL HYDROCHLORIDE [WHO-DD]
VERAPAMIL HCI
VERAPAMIL HYDROCHLORIDE [ORANGE BOOK]
Verapamil Injection
SMR000059109
Verapamil PB
V3888OEY5R
NCGC00258732-01
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard
Isoptin
VERAPAMIL HYDROCHLORIDE [USP MONOGRAPH]
Opera_ID_1210
V0118
Izoptin
Verapamil Hydrochloride 1.0 mg/ml in Methanol (as free base)
UNII-V3888OEY5R
BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, MONOHYDROCHLORIDE, (+/-)-
SPECTRUM2300307
Calan SR
Verapamil Ebewe
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
Cordilox SR
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxy phenyl)-2-isopropylvaleronitrile hydrochloride
Akilen
VERAPAMIL HYDROCHLORIDE [USP-RS]
alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile hydrochloride (1:1)
CCG-39491
FT-0655647
LU 20175
Geangin
Verapamyl hydrochloride
Verapamil.HCl, 1mg/ml in Methanol
Berkatens
Manidon Retard
CHEMBL1280
LP01237
SR-01000000050-11
(+/-)-Verapamil hydrochloride, Pharmaceutical Secondary Standard
Certified Reference Material
rac-2-(3,4-dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile hydrochloride
Veramex
TARKA COMPONENT VERAPAMIL HYDROCHLORIDE
Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride
Verapamil hydrochloride [USAN:USP:JAN]
Vera-Sanorania
VERAPAMIL HYDROCHLORIDE (USP-RS)
Civicor Retard
C27H38N2O4.HCl
Manidon
Hydrochloride, Verapamil
HY-A0064
BV164516
EU-0101237
Calan
Covera-hs (TN)
Dignover
NSC759589
Verapamil MSD
Nor Verapamil-d6 Hydrochloride
VERAPAMIL HYDROCHLORIDE [MI]
Univer
DTXSID2034095
VERAPAMIL HYDROCHLORIDE [EP IMPURITY]
Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride
Isoptine
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
Verapamil NM
VERAPAMIL HYDROCHLORIDE [JAN]
Verapamil Atid
(+/-)-VERAPAMIL HYDROCHLORIDE
HB1237
Verapamil hydrochloride (USAN:USP:JAN)
Verapamil AL
Verpamil
(y)-Verapamil hydrochloride
SCHEMBL33296
NCGC00094479-01
AC-16228
VERAPAMILI HYDROCHLORIDUM [WHO-IP LATIN]
VERAPAMIL HYDROCHLORIDE COMPONENT OF TARKA
SW196662-4
Verelan (TN)
Iproveratril hydrochloride
D88195
NSC-272366
Novo-Veramil
VERAPAMIL HYDROCHLORIDE [VANDF]
Verapamil hydrochloride, European Pharmacopoeia (EP) Reference Standard
Verapamil-AbZ
Isoptin SR
FT-0630593
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}-2-(methy lethyl)pentanenitrile, chloride
NCGC00094479-04
Verapamil NM Pharma
(2RS)-5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-(1-methylethyl)pentanenitrile monohydrochloride
CS-1685
Verapamil hydrochloride (JP17/USP)
Z1557407143
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride

物化性质

实验特性

LogP	5.89508
PSA	63.95000
Merck	9950
折射率	1.6290 (estimate)
水溶性	可溶
沸点	586.1°C at 760 mmHg
熔点	142 °C (dec.) (lit.)
闪点	9℃
FEMA	2385
溶解度	H2O: >30 mg/mL
颜色与性状	白色至灰白色粉末
溶解性	soluble
酸度系数(pKa)	8.6(at 25℃)
密度	1.0596 (rough estimate)

计算特性

精确分子量	490.26000
氢键供体数量	1
氢键受体数量	6
可旋转化学键数量	13
同位素质量	490.26
重原子数量	34
复杂度	606
同位素原子数量	0
确定原子立构中心数量	0
不确定原子立构中心数量	1
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	2
疏水参数计算参考值（XlogP）	无
互变异构体数量	无
表面电荷	0
拓扑分子极性表面积	64

安全信息

符号：	GHS06
RTECS号	YV8320000
WGK Germany	3
安全术语	6.1(b)
安全说明	S45-S36/37/39-S36/37
包装等级	III
风险术语	R23/24/25
危险品标志	T
危险品运输编号	UN 2811 6.1/PG 3
危害声明	H301,H311,H331
警示性声明	P261,P280,P301+P310,P311
提示语	危险
储存条件	4°C, protect from light
PackingGroup	III
危险类别码	23/24/25
信号词	Danger
毒性	LD50 in mice, rats (mg/kg): 7.6, 16 i.v.; 68, 107 s.c.; 68, 67 i.p.; 163, 114 orally (Haas, Hrtfelder)
HazardClass	6.1
FLUKA BRAND F CODES	8-10

国际标准相关数据

EINECS	205-800-5

海关数据

海关编码	2926909090
海关数据	中国海关编码： 2926909090 概述： 2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0% 申报要素：品名, 成分含量, 用途 Summary： HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

海关编码

2926909090

海关数据

中国海关编码：

2926909090

概述：

2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

Summary：

HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

生产方法和用途

用途	用于有机合成、医药工业;主要用于阵发性室上性心动过速,也用于心绞痛、高血压和肥厚型梗塞性心肌病

专业数据库参考

PubChemId	62969

参考资料

Reaxys RN	3647093
Beilstein	3647093

化合物详情（旧版）

盐酸维拉帕米物理化学性质

熔点：142 °C (dec.)(lit.)
储存条件：Refrigerator (+4°C)
溶解度：H2O: >30 mg/mL
form：solid
color：white
水溶解性：soluble
Merck：13,10012

盐酸维拉帕米产品用途

用于有机合成、医药工业;主要用于阵发性室上性心动过速，也用于心绞痛、高血压和肥厚型梗塞性心肌病。

盐酸维拉帕米化学品安全说明书(MSDS)

急救措施
食入：立即就医。洗净漱口水。
吸入：立即就医。删除立即从暴露到空气新鲜。如果没有呼吸，进行人工呼吸。如呼吸困难，给输氧。
皮肤：立即就医。立即用大量肥皂和水冲洗皮肤至少15分钟，而去除被污染的衣服和鞋子。
眼睛：立即冲洗眼睛用大量的水冲洗至少15分钟，偶尔抬一下上下眼皮。立即就医。
危害辨识
食入：可能引起消化道的刺激。毒物摄入。
吸入：可能引起呼吸道刺激症状。如果吸入有毒。可能会引起恶心，头晕，头痛等症状。
皮肤：可能会导致皮肤发炎。与皮肤接触有毒。
眼睛：可能引起眼睛发炎。
曝光控制/个人防护
个人防护：皮肤：穿戴适当的防护手套，以防止皮肤接触。服装：穿适当的防护服以防止皮肤接触。
呼吸器：按照OSHA呼吸器法规29CFR 1910.134或欧洲标准EN 149。始终使用NIOSH或欧洲标准EN 149批准的呼吸器必要时。
消防措施
佩戴自给式呼吸器压力需求的装置，MSHA / NIOSH（或同等学历），以及完整的护具。用火喷水，干粉，二氧化碳，或化学泡沫扑灭。
泄露处理
小泄漏/泄露：真空或清扫物质，并到一个合适的地方处置容器中。

盐酸维拉帕米处理和存储

贮藏方法：存放在密闭的容器中。电冰箱（约4℃）。
处理：不要吸入粉尘，蒸气，雾气或气体。不要让眼睛，皮肤或衣服。只有在使用化学通风柜。

产品用途

用于有机合成、医药工业;主要用于阵发性室上性心动过速，也用于心绞痛、高血压和肥厚型梗塞性心肌病

盐酸维拉帕米 | 152-11-4

中国海关编码：

概述：

申报要素：

Summary：

平台在线客服