简介名称和标识符别名信息物化性质安全信息相关文献化合物详情（旧版）相关分类

AZD9291(甲磺酸盐) | 1421373-66-1

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中文名称： AZD9291(甲磺酸盐)

英文名称： Osimertinib mesylate

CAS No.： 1421373-66-1

分子式： C₂₉H₃₇N₇O₅S

分子量： 595.7130

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：AZD9291(甲磺酸盐)结构式

MSDS： AZD9291(甲磺酸盐)MSDS

价格行情： AZD9291(甲磺酸盐)价格

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AZD9291(甲磺酸盐)的其他展现形式

美登素DM1

[(1S,2R,3S,5R,6S,16Z,18Z,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(3-sulfanylpropanoyl)amino]propanoate

CAS No.：139504-50-0
N-[1-(氨基羰基)-2,2-二甲基丙基]-1-[(4-氟苯基)甲基]-1H-吲唑-3-甲酰胺

N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-[(4-fluorophenyl)methyl]indazole-3-carboxamide

CAS No.：1445583-51-6
AZD-9291

Osimertinib

CAS No.：1421373-65-0
ABBV-075

Mivebresib

CAS No.：1445993-26-9
1-(4-乙基苯基)-2-(甲基氨基)-1-丙酮

1-(4-ethylphenyl)-2-(methylamino)-1-propanone

CAS No.：1225622-14-9
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester ethanesulfonate;Nintedanib ethanesulfonate;BIBF 1120 esylate;BIBF-1120 esylate;Nintedanib esylate;Nintedanib ethanesulfonate salt;BIBF1120/nintedanib ethanesulfonate salt;Trinidad Neeb esylate

CAS No.：656247-18-6

简介

Osimertinib mesylate (AZD-9291 mesylate) 是不可逆的突变体选择性 EGFR 抑制剂；对EGFRL858R 和EGFRL858R/T790M 的 IC50 值分别为12 和 1 nM。

名称和标识符

MDL	MFCD28137994
InChIKey	FUKSNUHSJBTCFJ-UHFFFAOYSA-N
Inchi	1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
SMILES	S(C([H])([H])[H])(=O)(=O)O[H].O(C([H])([H])[H])C1=C(C([H])=C(C(=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N([H])C(C([H])=C([H])[H])=O)N([H])C1=NC([H])=C([H])C(C2=C([H])N(C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C32)=N1

别名信息

- 中文别名 -

AZD9291(甲磺酸盐)
甲磺酸奥斯替尼
N-(2-((2-(二甲基氨基)乙基)(甲基)氨基)-4-甲氧基-5-((4-(1-甲基-1H-吲哚-3-基)嘧啶-2-基)氨基)苯基)丙烯酰胺甲磺酸盐(AZD9291)
甲磺酸迈瑞替尼(AZD-9291)
迈瑞替尼甲磺酸盐

奥斯替尼
N-[2-[[2-(二甲基氨基)乙基]甲基氨基]-4-甲氧基-5-[[4-(1-甲基-1H-吲哚-3-基)-2-嘧啶基]氨基]苯基]-2-丙烯酰胺甲磺酸盐
奥斯替尼(甲磺酸盐)
奥希替尼
AZD9291甲磺酸盐
3-(4-缩水甘油基丁氧基)-1,2-丙二醇
AZD-9291（甲磺酸盐）
AZD9291迈锐替尼
N-[2-[[2-(二甲基氨基)乙基]甲基氨基]-4-甲氧基-5-[[4-(1-甲基-1H-吲哚-3-基)-2-嘧啶基]氨基]苯基]-2-丙烯酰胺甲磺酸盐 (AZD9291甲磺酸盐)
甲磺酸迈瑞替尼
卡博替尼甲基磺酸盐
甲磺酸盐AZD9291
米里替布甲磺酸盐
米里替尼甲磺酸盐
奥希替尼甲磺酸盐

- 英文别名 -

AZD-9291 (Mesylate)
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1)
AZD-9291 mesylate N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1)
Mereletinib mesylate
Osimertinib

N-[2-(2-dimethylaminoethylmethylamino)-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide mesylate salt
Osimertinib Mesylate(AZD9291)
AZD9291 Mesylate
2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1)
AZD9291
AZD-9291
AZD-9291 mesylate
Osimertinib mesylate
(Mesylate)
N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide methanesulfonate
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate.
osimertinib mesilate
Tagrisso
Osimertinib mesylate [USAN]
RDL94R2A16
N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
methanesulfonic acid
Osimertinib mesylate (

物化性质

实验特性

LogP	5.81710
PSA	153.79000

计算特性

安全信息

危害声明	H302-H315-H319-H335
警示性声明	P261-P305+P351+P338
储存条件	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
信号词	Warning

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