| InChIKey | KBZOIRJILGZLEJ-UHFFFAOYSA-N |
| Inchi | InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53) |
| SMILES | C1=CC=C(CC2NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C(N)CSSCC(C(N3C(C(NC(C(NCC(N)=O)=O)CCC/N=C(\N)/N)=O)CCC3)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC2=O)C=C1 |
| LogP | 1.16100 |
| PSA | 512.03000 |
| 闪点 | 113℃ |
| 颜色与性状 | 白色粉末 |
| PH值 | ~3.5 |
| 密度 | 1.59 |
| 精确分子量 | 1083.44000 |
| 氢键供体数量 | 14 |
| 氢键受体数量 | 16 |
| 可旋转化学键数量 | 19 |
| 同位素质量 | 1083.437854 |
| 重原子数量 | 75 |
| 复杂度 | 2070 |
| 同位素原子数量 | 0 |
| 确定原子立构中心数量 | 0 |
| 不确定原子立构中心数量 | 8 |
| 确定化学键立构中心数量 | 0 |
| 不确定化学键立构中心数量 | 0 |
| 共价键单元数量 | 1 |
| 疏水参数计算参考值（XlogP） | -4.8 |
| 互变异构体数量 | 1001 |
| 表面电荷 | 0 |
| 拓扑分子极性表面积 | 464 |
| 用途 | 升压药 |
1.
Mechanisms and energetics of free radical initiated disulfide bond cleavage in model peptides and insulin by mass spectrometry
Chang Ho Sohn,Jinshan Gao,Daniel A. Thomas,Tae-Young Kim,William A. Goddard III,J. L. Beauchamp Chem. Sci. 2015 6 4550
2.
Synthesis of [1-(L- and [1-(D-2-hydroxy-3-mercaptopropanoic acid)-8-lysine]-vasopressin
Manfred W?lti,Derek B. Hope J. Chem. Soc. Perkin Trans. 1 1975 1691
3.
Hydrogen attachment dissociation of peptides containing disulfide bonds
Daiki Asakawa,Hidenori Takahashi,Shinichi Iwamoto,Koichi Tanaka Phys. Chem. Chem. Phys. 2019 21 26049
4.
The unusual co-ordination ability of vasopressin-like peptides; potentiometric and spectroscopic studies of some copper(II) and nickel(II) complexes
Henryk Kozlowski,Barbara Radomska,Gotfryd Kupryszewski,Bernard Lammek,Cynara Livera,Leslie D. Pettit,Simon Pyburn J. Chem. Soc. Dalton Trans. 1989 173
5.
Atmospheric pressure neutral reionization mass spectrometry for structural analysis
Pengyuan Liu,Pengyi Zhao,R. Graham Cooks,Hao Chen Chem. Sci. 2017 8 6499
6.
The structural effects of the Cys-S-S-Cys bridge exchange by the His-Cu(II)-His motif studied on natural peptides — a promising tool for natural compounds-based design
Justyna Brasuń,Marek Cebrat,?ukasz Jaremko,Mariusz Jaremko,Gregor Ilc,Olimpia G?adysz,Igor Zhukov Dalton Trans. 2009 4853
7.
Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry
Shawn T. Phillips,James N. Dodds,Berkley M. Ellis,Jody C. May,John A. McLean Chem. Commun. 2018 54 9398
8.
Mechanistic investigation of the on-surface enzymatic digestion (oSED) protein adsorption detection method using targeted mass spectrometry
Torgny Undin,Andreas Dahlin,Katarina H?rnaeus,Jonas Bergquist,Sara Bergstr?m Lind Analyst 2016 141 1714
9.
The unusual binding abilities of the His-analogue of Arg-vasopressin towards Cu2+
Justyna Brasuń,Marek Cebrat,Aleksandra Sochacka,Olimpia G?adysz,Jolanta ?wi?tek-Koz?owska Dalton Trans. 2008 4978
10.
Mathematical model for biomolecular quantification using large-area surface-enhanced Raman spectroscopy mapping
Mirkó Palla,Filippo G. Bosco,Jaeyoung Yang,Tomas Rindzevicius,Tommy S. Alstrom,Michael S. Schmidt,Qiao Lin,Jingyue Ju,Anja Boisen RSC Adv. 2015 5 85845
物理化学性质
产品用途
应用领域
精氨酸加压素(AVP)又称血管加压素、抗利尿激素或由下丘脑的视上核和室旁核细胞产生，贮存于神经垂体。在中枢神经系统可调节颅内压和脑组织代谢，具有抗利尿、缩血管、加强记忆、参与体温及免疫调节等生理功能。
精氨酸加压素正常值：成人 2.87±1.84ng/L，无部位间浓度差异新生儿 2.6±1.8ng/L，无部位间浓度差异精氨酸加压素临床意义：脑积水、颅内肿瘤、良性颅内压升高、脑外伤后48min～10天，新生儿缺氧缺血性脑病等患者CSF中AVP含量增高;含量减少见于原发性蛛网膜下腔出血、脑血栓形成、脑栓塞、帕金森氏病、基底神经节疾病、原发性退化性痴呆、偏头病等，其中原发性蛛网膜下腔出血昏迷者比嗜睡者下降更明显。
上下游产品信息
化学品安全说明书(MSDS)
储运特性
