找化学品上960化工网!
960化工网

(S)-(-)-美托洛尔 | 81024-42-2

(S)-(-)-美托洛尔结构式图片|81024-42-2结构式图片
(S)-(-)-美托洛尔
(S)-Metoprolol
81024-42-2
C15H25NO3
267.363904714584
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:(S)-(-)-美托洛尔结构式
157716
(S)-(-)-美托洛尔价格
名称和标识符
InChIKey IUBSYMUCCVWXPE-AWEZNQCLSA-N
Inchi 1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3/t14-/m0/s1
SMILES O(C1C=CC(CCOC)=CC=1)C[C@@H](O)CNC(C)C
别名信息
- 中文别名 -
  • (S)-美托洛尔
  • (S)-(-)-美多心安
  • (S)-(-)-美托洛尔
  • 美托洛尔
- 英文别名 -
  • (S)-1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol
  • (S)-(-)-METOPROLOL
  • (S)-Metoprolol
  • 2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2S)-
  • (2S)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (ACI)
  • 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)- (ZCI)
  • (-)-Metoprolol
  • (2S)-1-[4-(2-Methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
  • (S)-(-)-Metoprolol
  • 2-Propanol 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2S)-
物化性质
实验特性
熔点 41-43°C
计算特性
氢键供体数量 2
氢键受体数量 4
可旋转化学键数量 9
重原子数量 19
合成路线

合成路线:1 步

参考文献:
Kinetic resolution of aryl glycidyl ethers: a practical synthesis of the optically pure β-blocker S-metoprolol
Gurjar, Mukund K.; et al, Heterocycles, 1998, 48(7), 1471-1476

合成路线:1 步

参考文献:
Enantioseparations of 11 Amino Alcohols Using Di-n-amyl L-Tartrate-Boric Acid Complex as Chiral Mobile Phase Additive by RP-HPLC
Zou, Yanan; et al, Chromatographia, 2015, 78(11-12), 753-761

合成路线:1 步

反应条件:
参考文献:
Asymmetric hydrolytic kinetic resolution with recyclable polymeric Co(III)-salen complexes: a practical strategy in the preparation of (S)-metoprolol, (S)-toliprolol and (S)-alprenolol: computational rationale for enantioselectivity
Roy, Tamal; et al, Catalysis Science & Technology, 2014, 4(11), 3899-3908

合成路线:2 步

反应条件:
参考文献:
Concise Synthesis of Two β-Adrenergic Blocking Agents in High Stereoselectivity Using the Readily Available Chiral Building Block (2S,2'S,2''S)-Tris-(2,3-epoxypropyl)-isocyanurate
Sonawane, Swapnil P.; et al, Organic Process Research & Development, 2011, 15(6), 1365-1370

合成路线:1 步

反应条件:
参考文献:
Zinc Tetrafluoroborate Hydrate as a Mild Catalyst for Epoxide Ring Opening with Amines: Scope and Limitations of Metal Tetrafluoroborates and Applications in the Synthesis of Antihypertensive Drugs (RS)/(R)/(S)-Metoprolols
Pujala, Brahmam; et al, Journal of Organic Chemistry, 2011, 76(21), 8768-8780

合成路线:1 步

参考文献:
Immobilized cellulase (CBH I) as a chiral stationary phase for direct resolution of enantiomers
Erlandsson, Per; et al, Journal of the American Chemical Society, 1990, 112(11), 4573-4

合成路线:1 步

反应条件:
参考文献:
Catalysts for asymmetric synthesis and preparation of (S)-metoprolol
, Japan, , ,

合成路线:1 步

反应条件:
参考文献:
Application of kinetic resolution using HCS as chiral auxiliary: Novel synthesis of β-blockers (S)-betaxolol and (S)-metoprolol
Zhang, Jing-Yu; et al, Chirality, 2009, 21(8), 745-750

合成路线:1 步

反应条件:
参考文献:
A new route from D-mannitol to enantiomerically pure (S)-1-(alkylamino)-3-(aryloxy)-2-propanols
Lamm, Bo; et al, Acta Chemica Scandinavica, 1987, 41(3), 202-7

合成路线:2 步

反应条件:
参考文献:
Asymmetric synthesis of (S)-Metoprolol
Song, Guang-Wei; et al, Yingyong Huaxue, 2010, 27(11), 1286-1290

合成路线:1 步

反应条件:
参考文献:
Characterization of a single-isomer carboxymethyl-beta-cyclodextrin in chiral capillary electrophoresis
Fejos, Ida; et al, Electrophoresis, 2017, 38(15), 1869-1877

合成路线:1 步

反应条件:
参考文献:
Asymmetric synthesis of (S)-Metoprolol
Song, Guang-Wei; et al, Yingyong Huaxue, 2010, 27(11), 1286-1290

合成路线:1 步

反应条件:
参考文献:
Enantioselective ring opening of epoxides with trimethylsilyl azide (TMSN3) in the presence of β-cyclodextrin: an efficient route to 1,2-azido alcohols
Kamal, Ahmed; et al, Tetrahedron: Asymmetry, 1999, 10(22), 4261-4264

合成路线:2 步

反应条件:
参考文献:
A new route from D-mannitol to enantiomerically pure (S)-1-(alkylamino)-3-(aryloxy)-2-propanols
Lamm, Bo; et al, Acta Chemica Scandinavica, 1987, 41(3), 202-7

合成路线:1 步

反应条件:
参考文献:
Asymmetric synthesis of (S)-metoprolol via Sharpless asymmetric dihydroxylation induced by a recoverable polymer ligand QN-AQN-OPEG-OMe
Cheng, Sikun; et al, Letters in Organic Chemistry, 2012, 9(7), 516-519

合成路线:1 步

反应条件:
参考文献:
Concise Synthesis of Two β-Adrenergic Blocking Agents in High Stereoselectivity Using the Readily Available Chiral Building Block (2S,2'S,2''S)-Tris-(2,3-epoxypropyl)-isocyanurate
Sonawane, Swapnil P.; et al, Organic Process Research & Development, 2011, 15(6), 1365-1370

合成路线:1 步

反应条件:
参考文献:
Synthesis technique and control of impurities of (S)-succinate metoprolol
Di, Pan-pan; et al, Anhui Yiyao, 2015, 19(3), 427-430

合成路线:1 步

反应条件:
参考文献:
Asymmetric synthesis of (2S)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol [(S)-metoprolol]
Ji, Dehua; et al, Xiandai Huagong, 2008, 28(11), 58-59

合成路线:1 步

反应条件:
参考文献:
A new route from D-mannitol to enantiomerically pure (S)-1-(alkylamino)-3-(aryloxy)-2-propanols
Lamm, Bo; et al, Acta Chemica Scandinavica, 1987, 41(3), 202-7

合成路线:1 步

反应条件:
参考文献:
Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution
Muthukrishnan, M.; et al, Tetrahedron, 2007, 63(8), 1872-1876

合成路线:2 步

反应条件:
参考文献:
Synthesis of (S)-metoprolol by by asymmetric dihydroxylation
Xiang, Shun; et al, Hecheng Huaxue, 2011, 19(1), 127-129

合成路线:2 步

反应条件:
参考文献:
A new route from D-mannitol to enantiomerically pure (S)-1-(alkylamino)-3-(aryloxy)-2-propanols
Lamm, Bo; et al, Acta Chemica Scandinavica, 1987, 41(3), 202-7
相关文献
专业数据库参考
PubChemId 157716
960化工网为您提供(S)-(-)-美托洛尔专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:81024-42-2,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:81024-42-2
平台客服 平台客服

平台在线客服