1.1
Reagents:
Iodine
Solvents:
Dichloromethane
;
rt; 5 min, rt
1.2
Reagents:
Diisopropylethylamine
;
5 min, rt
1.3
Catalysts:
[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium
Solvents:
Toluene
;
rt; 12 - 16 h, reflux; reflux → rt; rt → 0 °C
1.4
Solvents:
Methanol
;
15 min, 0 °C