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可的松醋酸酯 | 50-04-4

可的松醋酸酯
Cortisone acetate
50-04-4
C23H30O6
402.4807
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:可的松醋酸酯结构式
2863
可的松醋酸酯价格
简介
Cortisone acetate (Cortisone 21-acetate),是 Cortisol(一种糖皮质激素)的氧化代谢产物。Cortisone acetate 具有免疫抑制和消炎的作用。Cortisone acetate 在高浓度下可以部分干预 Glucocorticoid 与 Glucocorticoid-receptor 的结合。
名称和标识符
MDL MFCD00003609
InChIKey ITRJWOMZKQRYTA-RFZYENFJSA-N
Inchi 1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
SMILES O([H])[C@]1(C(C([H])([H])OC(C([H])([H])[H])=O)=O)C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C(C([H])([H])[C@@]21C([H])([H])[H])=O)=O
BRN 2067543
别名信息
- 中文别名 -
  • 可的松醋酸酯
  • 醋酸可的松
  • 21-乙酰氧基-17α-羟基孕甾-4-烯-3,11,20-三酮
  • 醋酸皮质酮
  • 皮质素
  • 孕甾-4-烯-17α,21-二醇-3,11,20-三酮-21-醋酸酯
  • 醋酸肾上腺皮质激素
  • 可的松乙酸酯
  • 乙酸可的松
  • 乙酸肾上腺皮质激素
  • 17Α,21-二羟基-Δ4-孕甾烯-3,11,20-三酮-21-醋酸酯,17A,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE-21-ACETATE
  • 可的松醋酸酯原粉
  • Cortisone Acetate 醋酸可的松
  • 醋酸可的松,BR
  • 醋酸可的松,usp
  • 醋酸可的松标准品
  • 醋酸可的松标准品(JP)
  • 醋酸可的松杂质
  • 醋酸肾上腺皮质激
  • 可的松醋酸酯,醋酸可的松
- 英文别名 -
  • Cortisone acetate
  • 17,21-DIHYDROXYPREGN-4-ENE-3,11,20-TRIONE 21 ACETATE
  • 17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE
  • 4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • 4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE
  • 4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER
  • DELTA4-PREGNEN-17ALPHA-21-DIOL-3, 11, 20-TRIONE-21-ACETATE
  • KENDALL'S COMPOUND 'E' ACETATE
  • 11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate
  • 11-dehydro-17-hydroxycorticosterone-21-acetate
  • 11-dehydro-17-hydroxycorticosteroneacetate
  • 17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate
  • 20-trione,21-(acetyloxy)-17-hydroxy-pregn-4-ene-11
  • 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
  • 21-acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4
  • 21-acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione
  • acetatecortisone
  • C23H30O6
  • Cortisone 21-acetate
  • [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • 17α,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate
  • 21-Acetoxy-4-pregnen-17α-ol-3,11,20-trione
  • 4-Pregnene-17α,21-diol-3,11,20-trione 21-acetate
  • Cortisone-21-acetate
  • 21-Acetoxypregnen-17a-ol-3,11,20-trione
  • Cortone acetate
  • Incortin
  • Biocort acetate
  • Scheroson
  • Artriona
  • Cortadren
  • Cortisyl
  • Adreson
  • Irisone acetate
  • Cortelan
  • Cortistab
  • Ricortex
  • Corlin
  • Cortogen acetate
  • Compound E acetate
  • Cortisone (acetate)
  • Cortisone monoacetate
  • Cortisone, 21-acetate
  • Cortilen
  • 17,21-
  • Cortisone acetate [USAN:JAN]
  • cortisoneacetate
  • HYDROCORTISONE ACETATE IMPURITY D [EP IMPURITY]
  • Cortisone aceticum
  • 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione 21-acetate
  • 2-((8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • C08173
  • HMS3260H04
  • HY-17461A
  • HMS2235D24
  • CORTISONE ACETICUM [HPUS]
  • AB00384283-08
  • CORTISONE ACETATE [USP MONOGRAPH]
  • 11-Dehydro-17-hydroxycorticosterone-21-acetate
  • UNII-883WKN7W8X
  • CORTISONE ACETATE [ORANGE BOOK]
  • Cortisone acetate (JP17/USP)
  • BRD-K86161929-001-13-3
  • MLS002207136
  • Tox21_500271
  • 4-Pregnene-17,alpha,21-diol-3,11,20-trione 21-acetate
  • NSC49420
  • CCG-204366
  • NSC 49420
  • 21-Acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione
  • Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate
  • CORTISONE 21-ACETATE [MI]
  • D00973
  • D0X4RS
  • 21-Acetoxy-17.alpha.-hydroxypregn-4-ene-3,11,20-trione
  • NCGC00021191-07
  • CHEMBL1650
  • CORTISONE ACETATE [JAN]
  • LS-55003
  • MFCD00003609
  • NCGC00021191-09
  • C90609
  • AC-6827
  • Cortisone 21-acetate, >=99%
  • Pregn-4-ene-3,20-trione, 21-(acetyloxy)-17-hydroxy-
  • CORTISONE ACETATE [USP-RS]
  • Cortisone Acetate, Pharmaceutical Secondary Standard
  • Certified Reference Material
  • SCHEMBL4501
  • 11-Dehydro-17-hydroxycorticosterone acetate
  • CAS-50-04-4
  • Neosone (Salt/Mix)
  • CORTISONE ACETATE [MART.]
  • AB00384283_09
  • CORTISONE ACETATE [VANDF]
  • CORTISONE ACETATE [WHO-DD]
  • 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate #
  • DB01380
  • 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate
  • NCGC00021191-16
  • NC00677
  • LP00271
  • BCP08487
  • W-105993
  • 4-Pregnene-17.alpha.,21-diol-3,11,20-trione 21-acetate
  • cortisone-acetate
  • Cortisone acetate, European Pharmacopoeia (EP) Reference Standard
  • CORTISONE ACETATE
  • NCGC00021191-06
  • Cortisone acetate, United States Pharmacopeia (USP) Reference Standard
  • NCGC00260956-01
  • 21-Acetoxy-17.alpha.-hydroxy-3,11,20-triketopregnene-4
  • Cortisone acetate [USP:JAN]
  • 4-Pregnen-17.alpha.,21-diol-3,11,20-trione 21-acetate
  • Cortisyl artriona
  • CCRIS 3661
  • 883WKN7W8X
  • EU-0100271
  • AS-13692
  • CS-O-30561
  • Lopac0_000271
  • NCGC00021191-08
  • EN300-1709694
  • Z2238899644
  • DTXCID502858
  • MLS002548859
  • 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione acetate
  • EINECS 200-006-5
  • HMS3259N19
  • 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
  • Cortone acetate (TN)
  • component of Neosone
  • 50-04-4
  • AKOS005267225
  • 2-((1S,10S,11S,15S,2R,14R)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0 .0<2,7>.0<11,15>]heptadec-6-en-14-yl)-2-oxoethyl acetate
  • S2559
  • 17,21-Dihydroxypregn-4-ene-3,11,20-trione-21-acetate
  • SMR000059124
  • BDBM50455157
  • cortison-21-acetat
  • CORTISONE ACETATE [EP MONOGRAPH]
  • DTXSID0022858
  • Cortisone acetate (Cortone)
  • SDCCGSBI-0050259.P002
  • 2-[(1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-9a,11a-dimethyl-7,10-dioxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
  • Tox21_113482
  • [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
  • NCGC00021191-03
  • MLS000069478
  • Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
  • LMST02030120
  • Pregn-4-ene-3,20-trione, 17,21-dihydroxy-, 21-acetate
  • Acetate cortisone
  • 21-Acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4
  • CHEBI:3897
  • Tox21_113482_1
  • CS-1742
  • 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate
  • 21-Acetoxy-4-pregnen-17alpha-ol-3,11,20-trione
  • NSC-49420
  • NS00006620
  • Cortisone acetate (USP:JAN)
  • CORTISONE ACETATE (USP MONOGRAPH)
  • CORTISONE ACETATE (USP-RS)
  • CORTISONE ACETATE (EP MONOGRAPH)
  • CORTISONE ACETATE (MART.)
  • 6alpha,9Difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-Butyrate
  • 4-Pregnene-17alpha,21-diol-3,11,20-trione 21-acetate
物化性质
实验特性
LogP 2.56060
PSA 97.74000
Merck 2539
折射率 212 ° (C=1, MeOH)
沸点 577.3°C at 760mmHg
熔点 237-240?°C(lit.)
蒸气压 0mmHg at 25°C
闪点 197.3°C
溶解度 DMSO 7 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
颜色与性状 固体
稳定性 Stable. Incompatible with strong oxidizing agents.
溶解性 未确定
比旋光度 +207° - +216° (c=1, MeOH)
密度 1.26g/cm3
计算特性
精确分子量 402.20400
氢键供体数量 1
氢键受体数量 6
可旋转化学键数量 4
同位素质量 402.20423867g/mol
重原子数量 29
复杂度 827
同位素原子数量 0
确定原子立构中心数量 6
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 2.1
互变异构体数量 30
表面电荷 0
拓扑分子极性表面积 97.7
国际标准相关数据
EINECS 3661
生产方法和用途
方法
以醋酸孕甾双烯醇酮为原料,依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16,17α环氧黄体酮,经氢溴酸开环,氢化脱溴得可的松,后者与碘反应,再与熔融醋酸钾作用得粗品,最后重结晶而得。
用妊娠双烯醇酮经环氧化、沃氏氧化、霉菌氧化、铬酸氧化、溴化氢开环,雷尼镍催化脱溴、碘化并乙酰氧基置换制得。
用途
生化研究,肾上腺皮质激素类药物,具有抗炎、抗过敏等作用。
泼尼松醋酸酯的中间体。本身为抗炎剂。用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病。
相关文献
专业数据库参考
PubChemId 2863
参考资料
Beilstein 2067543
化合物详情(旧版)

可的松醋酸酯的物理化学性质

性状:白色针状结晶或结晶性粉末(丙酮),无气味
折射率  212 ° (C=1, MeOH)
密度:1.26g/cm3
熔点:237-240 °C(lit.)
沸点:577.3ºC at 760mmHg
闪点:197.3ºC
折射率:212 ° (C=1, MeOH)

可的松醋酸酯的用途

用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病的治疗
泼尼松醋酸酯的中间体。本身为抗炎剂。用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病。 
含量达97.0%-103.0%,mp≥238C,比旋光度[α]20D+208°- +217°,检测干燥失重及灼烧残渣等杂质含量。 

化学品安全说明书(MSDS) 

【急救措施】
吸入:将受害者移到新鲜空气处,保持呼吸通畅,休息。若感不适请求医/就诊。    
皮肤接触:立即去除/脱掉所有被污染的衣物。用水清洗皮肤/淋浴。若皮肤刺激或发生皮疹:求医/就诊。
眼睛接触:用水小心清洗几分钟。如果方便,易操作,摘除隐形眼镜。继续清洗。 如果眼睛刺激,求医/就诊。
食入:若感不适,求医/就诊。漱口。    
紧急救助者的防护:救援者需要穿戴个人防护用品,比如橡胶手套和气密性护目镜。    

【消防措施】
合适的灭火剂:干粉,泡沫,雾状水,二氧化碳
特定方法:从上风处灭火,根据周围环境选择合适的灭火方法。非相关人员应该撤离至安全地方。
周围一旦着火:如果安全,移去可移动容器。
消防员的特殊防护用具:灭火时,一定要穿戴个人防护用品。    

【泄漏应急处理】
个人防护措施、防护用具:使用个人防护用品。远离溢出物/泄露处并处在上风处。    
紧急措施:泄露区应该用安全带等圈起来,控制非相关人员进入。    
环保措施:防止进入下水道。    
控制和清洗的方法和材料:清扫收集粉尘,封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的法律法规处置。

储运特性 

保持容器密闭。冷藏储存。    
远离不相容的材料比如氧化剂存放。

产品用途
用于治疗肾上腺皮质低功能症、类风湿性关节炎、风湿病、红斑狼疮等病的治疗
可的松醋酸酯推荐生产厂家
960化工网为您提供可的松醋酸酯专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:50-04-4,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:50-04-4
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