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林可霉素 | 154-21-2

林可霉素
lincomycin
154-21-2
C18H34N2O6S
406.537
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:林可霉素结构式
3000540
林可霉素价格
简介
        林可霉素(Lincomycin),白色结晶固体药品,是一种作用于敏感菌核糖体的50S亚基,阻止肽链的延长,从而抑制细菌细胞的蛋白质合成。
名称和标识符
MDL MFCD00135816
InChIKey OJMMVQQUTAEWLP-KIDUDLJLSA-N
Inchi InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
SMILES CCC[C@@H]1C[C@H](N(C1)C)C(N[C@@H]([C@@H]2[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O2)[C@H](O)C)=O
别名信息
- 中文别名 -
  • 林可霉素
  • 洁霉素
  • 林肯霉素
  • 6,8-二脱氧-6-(1-甲基-4-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-D-赤式-alpha-D-半乳辛吡喃糖苷
  • 盐酸林可霉素
  • 林可黴素
  • EP克林霉素杂质A
  • 磷酸克林霉素杂质 A
- 英文别名 -
  • LINCOMYCIN
  • N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
  • U-10149A
  • lincomyicin
  • Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
  • C18H34N2O6S
  • Lincomycin,(2S-cis)-Isomer
  • UNII-BOD072YW0F
  • U-10149
  • Myvicin
  • Albiotic
  • jiemycin
  • Lincocine
  • NSC-70731
  • Cillimycin
  • LYNCOMYCIN
  • LINCOMYCIN (USP IMPURITY)
  • LINCOMYCIN (USP IMPURITY)
  • Lincomycinum (INN-Latin)
  • Lincomycinum (INN-Latin)
  • D-Erythro-.alpha.-D-gluco-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
  • D-Erythro-.alpha.-D-gluco-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
  • U 10,149A
  • U 10,149A
  • LINCOMIX 20, LINCOMIX 50
  • LINCOMIX 20, LINCOMIX 50
  • LINCOMYCIN [MART.]
  • LINCOMYCIN [MART.]
  • Lincomycinum [INN-Latin]
  • Lincomycinum [INN-Latin]
  • HSDB 3109
  • HSDB 3109
  • OJMMVQQUTAEWLP-KIDUDLJLSA-N
  • OJMMVQQUTAEWLP-KIDUDLJLSA-N
  • D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-alpha-
  • D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-alpha-
  • (2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • (2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • AC1MHD7X
  • AC1MHD7X
  • SCHEMBL4010
  • SCHEMBL4010
  • Linocin
  • Linocin
  • LINCOMYCIN [MI]
  • LINCOMYCIN [MI]
  • (2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • (2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • 1-Methyl-4-propyl-pyrrolidine-2-carboxylic acid [2-hydroxy-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide
  • 1-Methyl-4-propyl-pyrrolidine-2-carboxylic acid [2-hydroxy-1-(3,4,5-trihydroxy-6-methylsulfanyl-tetrahydro-pyran-2-yl)-propyl]-amide
  • C06812
  • C06812
  • U10149A
  • U10149A
  • CLINDAMYCIN HYDROCHLORIDE IMPURITY A [IP]
  • CLINDAMYCIN HYDROCHLORIDE IMPURITY A [IP]
  • EN300-118720
  • EN300-118720
  • CLINDAMYCIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]
  • CLINDAMYCIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]
  • CCG-208231
  • CCG-208231
  • Lincomycin Injectable, USP
  • Lincomycin Injectable, USP
  • Lincomycine [French]
  • Lincomycine [French]
  • HMS2089A13
  • HMS2089A13
  • SMP1_000178
  • SMP1_000178
  • Frademicina
  • Frademicina
  • LINCOMYCIN [INN]
  • LINCOMYCIN [INN]
  • NS00000025
  • NS00000025
  • Lincomicina
  • Lincomicina
  • D00223
  • D00223
  • Lincomycine (INN-French)
  • Lincomycine (INN-French)
  • Lincomycin, Antibiotic for Culture Media Use Only
  • Lincomycin, Antibiotic for Culture Media Use Only
  • DTXCID003215
  • DTXCID003215
  • LINCOMYCIN [USP IMPURITY]
  • LINCOMYCIN [USP IMPURITY]
  • GTPL10941
  • GTPL10941
  • Lincomycin (USAN/INN)
  • Lincomycin (USAN/INN)
  • lincomycin
  • lincomycin
  • CHEBI:6472
  • CHEBI:6472
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Lincocin
  • Lincocin
  • METHYL 6,8-DIDEOXY-6-((((2S,4R)-1-METHYL-4-PROPYLPYRROLIDIN-2-YL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE
  • METHYL 6,8-DIDEOXY-6-((((2S,4R)-1-METHYL-4-PROPYLPYRROLIDIN-2-YL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE
  • (2S-trans)-Methyl 6,8-dideoxy-6-
  • (2S-trans)-Methyl 6,8-dideoxy-6-
  • methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • LINCOMYCIN [USAN]
  • LINCOMYCIN [USAN]
  • D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-
  • D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-
  • DB01627
  • DB01627
  • CLINDAMYCIN PHOSPHATE IMPURITY A [EP IMPURITY]
  • CLINDAMYCIN PHOSPHATE IMPURITY A [EP IMPURITY]
  • CHEMBL1447
  • CHEMBL1447
  • methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • LINCOMYCIN [WHO-DD]
  • LINCOMYCIN [WHO-DD]
  • Bactramycin
  • Bactramycin
  • LINCOMYCIN 100, LINCOMYCIN 25, LINCOMYCIN 300
  • LINCOMYCIN 100, LINCOMYCIN 25, LINCOMYCIN 300
  • NSC70731
  • NSC70731
  • (2S,4R)-N-((1S)-2-hydroxy-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • (2S,4R)-N-((1S)-2-hydroxy-1-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • U-10,149
  • U-10,149
  • BRD-K49384696-003-01-9
  • BRD-K49384696-003-01-9
  • LINCOMYCIN [GREEN BOOK]
  • LINCOMYCIN [GREEN BOOK]
  • U 10,1499
  • U 10,1499
  • Lincorex
  • Lincorex
  • AB01275426-01
  • AB01275426-01
  • Methyl (5r)-5-[(1r,2r)-2-Hydroxy-1-{[(4r)-1-Methyl-4-Propyl-L-Prolyl]amino}propyl]-1-Thio-Beta-L-Arabinopyranoside
  • Methyl (5r)-5-[(1r,2r)-2-Hydroxy-1-{[(4r)-1-Methyl-4-Propyl-L-Prolyl]amino}propyl]-1-Thio-Beta-L-Arabinopyranoside
  • LINCOMYCIN [HSDB]
  • LINCOMYCIN [HSDB]
  • BRN 0707677
  • BRN 0707677
  • LINCOMYCIN [VANDF]
  • LINCOMYCIN [VANDF]
  • W-109518
  • W-109518
  • CS-0066775
  • CS-0066775
  • DTXSID3023215
  • DTXSID3023215
  • (2S-TRANS)-METHYL 6,8-DIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE
  • (2S-TRANS)-METHYL 6,8-DIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE
  • L-Mycin
  • L-Mycin
  • METHYL 6,8-DIDEOXY-6-((((2S,4R)-1-METHYL-4-PROPYLPYRROLIDIN-2-YL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-alpha-D-GALACTO-OCTOPYRANOSIDE
  • METHYL 6,8-DIDEOXY-6-((((2S,4R)-1-METHYL-4-PROPYLPYRROLIDIN-2-YL)CARBONYL)AMINO)-1-THIO-D-ERYTHRO-alpha-D-GALACTO-OCTOPYRANOSIDE
  • Lincomycin Injectable 30%
  • Lincomycin Injectable 30%
  • Lincomycinum
  • Lincomycinum
  • LINCOMYCIN (MART.)
  • LINCOMYCIN (MART.)
  • Lincomycin [USAN:INN:BAN]
  • Lincomycin [USAN:INN:BAN]
  • Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-D-galacto-octopyranoside (alpha-form)
  • Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-D-galacto-octopyranoside (alpha-form)
  • EINECS 205-824-6
  • EINECS 205-824-6
  • D-ERYTHRO-ALPHA-D-GALACTO-OCTOPYRANOSIDE, METHYL 6,8-DIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-, TRANS- ALPHA-
  • D-ERYTHRO-ALPHA-D-GALACTO-OCTOPYRANOSIDE, METHYL 6,8-DIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-, TRANS- ALPHA-
  • CLINDAMYCIN PHOSPHATE IMPURITY A (EP IMPURITY)
  • CLINDAMYCIN PHOSPHATE IMPURITY A (EP IMPURITY)
  • Lincomycin,(S)
  • Lincomycin,(S)
  • Lincolnensin
  • Lincolnensin
  • D-ERYTHRO-D-GALACTO-OCTOPYRANOSIDE, METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-L-2-PYRROLIDINECARBOXAMIDO)-1-THIO-, TRANS- ALPHA
  • D-ERYTHRO-D-GALACTO-OCTOPYRANOSIDE, METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-L-2-PYRROLIDINECARBOXAMIDO)-1-THIO-, TRANS- ALPHA
  • Lincomicina (INN-Spanish)
  • Lincomicina (INN-Spanish)
  • LCM
  • LCM
  • AKOS015951392
  • AKOS015951392
  • 154-21-2
  • 154-21-2
  • D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-
  • D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-
  • Lincomycin, (2S-cis)-Isomer
  • Lincomycin, (2S-cis)-Isomer
  • Q423428
  • Q423428
  • 3QB
  • 3QB
  • Z1515385088
  • Z1515385088
  • U 10149
  • U 10149
  • BDBM50335522
  • BDBM50335522
  • LincoMed 300
  • LincoMed 300
  • U10149
  • U10149
  • J01FF02
  • J01FF02
  • Lincomycine
  • Lincomycine
  • Lincomyocin
  • Lincomyocin
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-tetrahydropyran-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
  • LINCOMYCIN [ORANGE BOOK]
  • LINCOMYCIN [ORANGE BOOK]
  • Jiemycin
  • Jiemycin
  • Lincolcina
  • Lincolcina
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-.alpha.-D-galacto-octopyranoside
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-.alpha.-D-galacto-octopyranoside
  • BOD072YW0F
  • BOD072YW0F
  • HY-117660
  • HY-117660
  • Lincomicina [INN-Spanish]
  • Lincomicina [INN-Spanish]
  • Lincomycine [INN-French]
  • Lincomycine [INN-French]
  • Lincomycin A
  • Lincomycin A
物化性质
实验特性
LogP 0.27380
PSA 147.79000
折射率 1.6510 (estimate)
熔点 148-150°C
颜色与性状 白色结晶固体
溶解性 水或甲醇中易溶,在乙醇中略溶
酸度系数(pKa) 7.6(at 25℃)
密度 1.1704 (rough estimate)
计算特性
精确分子量 442.19000
氢键供体数量 5
氢键受体数量 8
可旋转化学键数量 8
同位素质量 406.214
重原子数量 27
复杂度 499
同位素原子数量 0
确定原子立构中心数量 9
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP)
互变异构体数量 2
表面电荷 0
拓扑分子极性表面积 148A^2
国际标准相关数据
EINECS 205-824-6
海关数据
海关数据

中国海关编码:

2941904000
生产方法和用途
用途

一,作为抗生素,主要用于治疗鸡的慢性呼吸道疾病和耐青霉素G的金色葡萄球菌和链球菌引起的感染。

二,也能促进鸡肉的生长。

生产方法

链霉菌(Streptomyces lincolnensis)变异株发酵产生。

专业数据库参考
PubChemId 3000540
参考资料
Reaxys RN
化合物详情(旧版)

药理作用

林可霉素作用于敏感菌核糖体的50S亚基,阻止肽链的延长,从而抑制细菌细胞的蛋白质合成。林可霉素一般系抑菌剂,但在高浓度下,对高度敏感细菌也具有杀菌作用。 

适应症

本品用于骨髓炎治疗口服适用于:葡萄球菌化脓性链球菌肺炎球菌厌氧菌所致的呼吸道感染、皮肤软组织感染、女性生殖道及盆腔感染和厌氧菌所致的腹腔感染等。林可霉素注射液除上述指征外,尚可用于链球菌和葡萄球菌所致的败血症、骨和关节感染、慢性骨和关节感染的外科辅助治疗、葡萄球菌所致的急性血源性骨髓炎等。林可霉素渗入脑脊液的浓度不能到达有效水平,不适用于脑膜炎的治疗。 

960化工网为您提供林可霉素专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:154-21-2,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:154-21-2
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