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MIPOMERSEN | 1000120-98-8

MIPOMERSEN结构式图片|1000120-98-8结构式图片
MIPOMERSEN
mipomersen
1000120-98-8
C230H324N67O122P19S19
7177.14574241638
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:MIPOMERSEN结构式
简介
Mipomersen (ISIS 301012 free base) 是载脂蛋白 B (apoB) 的反义寡核苷酸抑制剂。Mipomersen 具有抗 HCV 的作用,可降低 HCV 的感染性。Mipomersen 可用于纯合子家族性高胆固醇血症 (HoFH) 的研究。
名称和标识符
InChIKey XLTMQWVJFPYGMC-QVKFEXRMSA-N
Inchi 1S/C230H324N67O122P19S19/c1-97-55-278(217(309)256-177(97)231)141-45-111(122(381-141)70-362-422(325,441)404-116-50-146(283-66-108(12)196(302)275-228(283)320)387-128(116)76-368-427(330,446)410-120-54-150(294-93-253-154-191(294)266-214(243)270-200(154)306)390-130(120)78-370-428(331,447)408-118-52-148(292-91-250-151-186(240)246-89-248-188(151)292)388-131(118)79-371-430(333,449)412-159-134(394-204(169(159)354-37-27-344-17)286-59-101(5)181(235)260-221(286)313)83-375-435(338,454)417-164-138(398-209(174(164)359-42-32-349-22)291-68-110(14)198(304)277-230(291)322)87-377-434(337,453)415-162-136(396-207(172(162)357-40-30-347-20)289-62-104(8)184(238)263-224(289)316)85-376-433(336,452)414-161-133(393-206(171(161)356-39-29-346-19)288-61-103(7)183(237)262-223(288)315)82-374-432(335,451)411-158-121(69-298)391-211(168(158)353-36-26-343-16)296-95-254-155-192(296)267-215(244)271-201(155)307)401-420(323,439)365-74-127-117(51-147(386-127)284-67-109(13)197(303)276-229(284)321)406-425(328,444)369-77-129-119(53-149(389-129)293-92-252-153-190(293)265-213(242)269-199(153)305)409-426(329,445)367-71-123-112(46-142(382-123)279-56-98(2)178(232)257-218(279)310)402-421(324,440)364-73-125-115(49-145(384-125)282-65-107(11)195(301)274-227(282)319)405-424(327,443)366-75-126-114(48-144(385-126)281-64-106(10)194(300)273-226(281)318)403-423(326,442)363-72-124-113(47-143(383-124)280-57-99(3)179(233)258-219(280)311)407-429(332,448)373-81-139-166(176(361-44-34-351-24)212(400-139)297-96-255-156-193(297)268-216(245)272-202(156)308)419-438(341,457)379-86-137-163(173(358-41-31-348-21)208(397-137)290-63-105(9)185(239)264-225(290)317)416-436(339,455)380-88-140-165(175(360-43-33-350-23)210(399-140)295-94-251-152-187(241)247-90-249-189(152)295)418-437(340,456)378-84-135-160(170(355-38-28-345-18)205(395-135)287-60-102(6)182(236)261-222(287)314)413-431(334,450)372-80-132-157(299)167(352-35-25-342-15)203(392-132)285-58-100(4)180(234)259-220(285)312/h55-68,89-96,111-150,157-176,203-212,298-299H,25-54,69-88H2,1-24H3,(H,323,439)(H,324,440)(H,325,441)(H,326,442)(H,327,443)(H,328,444)(H,329,445)(H,330,446)(H,331,447)(H,332,448)(H,333,449)(H,334,450)(H,335,451)(H,336,452)(H,337,453)(H,338,454)(H,339,455)(H,340,456)(H,341,457)(H2,231,256,309)(H2,232,257,310)(H2,233,258,311)(H2,234,259,312)(H2,235,260,313)(H2,236,261,314)(H2,237,262,315)(H2,238,263,316)(H2,239,264,317)(H2,240,246,248)(H2,241,247,249)(H,273,300,318)(H,274,301,319)(H,275,302,320)(H,276,303,321)(H,277,304,322)(H3,242,265,269,305)(H3,243,266,270,306)(H3,244,267,271,307)(H3,245,268,272,308)/t111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,157+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174+,175+,176+,203+,204+,205+,206+,207+,208+,209+,210+,211+,212+,420?,421?,422?,423?,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?/m0/s1
SMILES S([H])P(=O)(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C(N=C(C(C([H])([H])[H])=C2[H])N([H])[H])=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])OP(O[H])(OC([H])([H])[C@]1([H])[C@]([H])([C@]([H])([C@]([H])(N2C(N=C(C(C([H])([H])[H])=C2[H])N([H])[H])=O)O1)OC([H])([H])C([H])([H])OC([H])([H])[H])O[H])=S)O[C@]1([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]2([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]3([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N=C(C(C([H])([H])[H])=C5[H])N([H])[H])=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N=C(C(C([H])([H])[H])=C5[H])N([H])[H])=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C([H])=NC6C(N([H])C(N([H])[H])=NC5=6)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N=C(C(C([H])([H])[H])=C5[H])N([H])[H])=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C([H])=NC6C(N([H])C(N([H])[H])=NC5=6)=O)O[C@]4([H])C([H])([H])OP(O[H])(O[C@@]4([H])C([H])([H])[C@]([H])(N5C([H])=NC6=C(N([H])[H])N=C([H])N=C56)O[C@]4([H])C([H])([H])OP(O[H])(O[C@]4([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]5([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]6([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]7([H])[C@@]([H])(C([H])([H])OP(O[H])(O[C@]8([H])[C@@]([H])(C([H])([H])O[H])O[C@]([H])([C@]8([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N8C([H])=NC9C(N([H])C(N([H])[H])=NC8=9)=O)=S)O[C@]([H])([C@]7([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N7C(N=C(C(C([H])([H])[H])=C7[H])N([H])[H])=O)=S)O[C@]([H])([C@]6([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N6C(N=C(C(C([H])([H])[H])=C6[H])N([H])[H])=O)=S)O[C@]([H])([C@]5([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N5C(N([H])C(C(C([H])([H])[H])=C5[H])=O)=O)=S)O[C@]([H])([C@]4([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N4C(N=C(C(C([H])([H])[H])=C4[H])N([H])[H])=O)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)=S)O[C@]([H])([C@]3([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N3C([H])=NC4C(N([H])C(N([H])[H])=NC3=4)=O)=S)O[C@]([H])([C@]2([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N2C(N=C(C(C([H])([H])[H])=C2[H])N([H])[H])=O)=S)O[C@]([H])([C@]1([H])OC([H])([H])C([H])([H])OC([H])([H])[H])N1C([H])=NC2=C(N([H])[H])N=C([H])N=C12
别名信息
- 中文别名 -
  • 米泊美生钠
- 英文别名 -
  • DNA,d(P-thio)([2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-A-G-T-m5C-T-G-m5C-T-T-m5C-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC)
  • DNA,d(P-thio)([2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[
  • ISIS 301012 Parent Acid
  • mipomersen
化合物详情(旧版)

SMILES

C1(C)C(N)=NC(=O)N(C2C(C(C(COP(=S)(O)OC3C(COP(O)(OC4C(COP(=S)(O)OC5C(OCCOC)C(OC5COP(O)(OC6C(OC(N7C=NC8C(=O)NC(=NC7=8)N)C6OCCOC)CO)=S)N9C=C(C)C(=NC9=O)N)OC(C4OCCOC)N%10C(=O)N=C(C(=C%10)C)N)=S)OC(C3OCCOC)N%11C=C(C(=O)NC%11=O)C)O2)OP(=S)(O)OCC%12C(OP(=S)(O)OCC%13C(CC(O%13)N%14C=NC%15=C%14N=C(N)NC%15=O)OP(=S)(O)OCC%16C(OP(O)(OCC%17C(OP(O)(OCC%18OC(CC%18OP(O)(OCC%19C(OP(=S)(O)OCC%20OC(N%21C=C(C)C(=NC%21=O)N)CC%20OP(=S)(O)OCC%22OC(N%23C=C(C(NC%23=O)=O)C)CC%22OP(O)(OCC%24OC(N%25C=C(C(=O)NC%25=O)C)CC%24OP(O)(OCC%26OC(CC%26OP(O)(OCC%27C(C(C(O%27)N%28C=NC%29=C%28N=C(NC%29=O)N)OCCOC)OP(=S)(O)OCC%30C(OP(=S)(O)OCC%31OC(C(C%31OP(=S)(O)OCC%32OC(C(C%32OP(=O)(OCC%33OC(N%34C=C(C(N)=NC%34=O)C)C(C%33O)OCCOC)S)OCCOC)N%35C(=O)N=C(C(C)=C%35)N)OCCOC)N%36C=NC%37=C(N)N=CN=C%36%37)C(OCCOC)C(O%30)N%38C(N=C(C(=C%38)C)N)=O)=S)N%39C(N=C(N)C(=C%39)C)=O)=S)=S)CC(O%19)N%40C=NC%41=C%40N=C(N)NC%41=O)=S)N%42C=C(C)C(NC%42=O)=O)=S)CC(O%17)N%43C(=O)N=C(C(=C%43)C)N)=S)CC(O%16)N%44C=C(C)C(NC%44=O)=O)CC(O%12)N%45C=NC%46=C(N=CN=C%46%45)N)OCCOC)C=1

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960化工网为您提供MIPOMERSEN专业化合物百科信息,包括中文名,英文名,分子式,分子量,以及该化合物的CasNo.:1000120-98-8,和相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等;| WAP 版:1000120-98-8
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